Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis

Organic Letters

Volumn 8, Issue 2, 2006, Pages 321-324

  Marion, Frederic ^a   Williams, David E ^a   Patrick, Brian O ^a   Hollander, Irwin ^c   Mallon, Robert ^c   Kim, Steven C ^c   Roll, Deborah M ^c   Feldberg, Larry ^c   Van Soest, Rob ^b   Andersen, Raymond J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; LIPHAGAL; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; TERPENE; WORTMANNIN;

ANIMAL; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; SPONGE (PORIFERA); SYNTHESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CHROMONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; MORPHOLINES; PORIFERA; TERPENES; TUMOR CELLS, CULTURED;

EID: 31444457132     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol052744t     Document Type: Article

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