Age-related macular degeneration: A new viewpoint

Frontiers in Bioscience

Volumn 8, Issue , 2003, Pages

  Hamdi, Hamdi K ^a   Kenney, Cristina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ACE; Age; Alu; Degeneration; Macula; Review

Indexed keywords

ADENOSINE TRIPHOSPHATE BINDING CASSETTE RIM PROTEIN; APOLIPOPROTEIN E; DIPEPTIDYL CARBOXYPEPTIDASE; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ATROPHY; BIOCHEMISTRY; BIOLOGY; CLINICAL FEATURE; DISEASE ASSOCIATION; DRY EYE; EPIDEMIOLOGICAL DATA; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; METABOLISM; RETINA; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; REVIEW; RISK FACTOR;

EID: 3142775708     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

1. Abdelsalam, A., L. Del Priore and M.A. Zarbin: Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Surv Ophthalmol 44, 1-29 (1999)
2. Algvere, P.V.: Clinical possibilities in retinal pigment epithelial transplantations. Acta Ophthalmol Scand 75, 1 (1997)
3. Algvere, P.V., L. Berglin, P. Gouras, Y. Sheng and E.D. Kopp: Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefes Arch Clin Exp Ophthalmol 235, 149-158 (1997)
4. Allikmets, R.: A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 17, 122 (1997)
5. Allikmets, R.: Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genet 67, 487-491 (2000)
6. Allikmets, R., N.F. Shroyer, N. Singh, J.M. Seddon, R.A. Lewis, P.S. Bernstein, A. Peiffer, N.A. Zabriskie, Y. Li, A. Hutchinson, M. Dean, J.R. Lupski and M. Leppert: Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277, 1805-1807 (1997)
7. Allikmets, R., W.W. Wasserman, A. Hutchinson, P. Smallwood, J. Nathans, P.K. Rogan, T.D. Schneider and M. Dean: Organization of the ABCR gene: analysis of promoter and splice junction sequences. Gene 215, 111-122 (1998)
8. Bensaoula, T. and A. Ottlecz: Biochemical and ultrastructural studies in the neural retina and retinal pigment epithelium of STZ-diabetic rats: effect of captopril. J Ocul Pharmacol Ther 17, 573-586 (2001)
9. Bernstein, P.S., W.C. Law and R.R. Rando: Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro. Proc Natl Acad Sci U S A 84, 1849-1853 (1987)
10. Bernstein, P.S. and R.R. Rando: In vivo isomerization of all-trans- to 11-cis-retinoids in the eye occurs at the alcohol oxidation state. Biochemistry 25, 6473-6478 (1986)
11. Briggs, C.E., D. Rucinski, P.J. Rosenfeld, T. Hirose, E.L. Berson and T.P. Dryja: Mutations in ABCR (ABCA4) in patients with Stargardt macular degeneration or cone-rod degeneration. Invest Ophthalmol Vis Sci 42, 2229-2236 (2001)
12. Buhagiar, K.A., P.S. Hansen, D.F. Gray, A.S. Mihailidou and H.H. Rasmussen: Angiotensin regulates the selectivity of the Na+-K+ pump for intracellular Na+. Am J Physiol 277, C461-468 (1999)
13. Curcio, C.A.: Photoreceptor topography in ageing and age-related maculopathy. Eye 15, 376-383 (2001)
14. Curcio, C.A., C. Owsley and G.R. Jackson: Spare the rods, save the cones in aging and age-related maculopathy. Invest Ophthalmol Vis Sci 41, 2015-2018 (2000)
15. Das, H.K., J. McPherson, G.A. Bruns, S.K. Karathanasis and J.L. Breslow: Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem 260, 6240-6247 (1985)
16. De Jong, P.T., A.A. Bergen, C.C. Klaver, C.M. Van Duijn and J.M. Assink: Age-related maculopathy: its genetic basis. Eye 15, 396-400 (2001)
17. De La Paz, M.A., M.A. Pericak-Vance, F. Lennon, J.L. Haines and J.M. Seddon: Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci 38, 1060-1065 (1997)
18. Deigner, P.S., W.C. Law, F.J. Canada and R.R. Rando: Membranes as the energy source in the endergonic transformation of vitamin A to 11-cis-retinol. Science 244, 968-971 (1989)
19. Dosso, A.A. and J. Bovet: Monozygotic twin brothers with age-related macular degeneration. Ophthalmologica 205, 24-28 (1992)
20. Dryja, T.P., D.E. Rucinski, S.H. Chen and E.L. Berson: Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci 40, 1859-1865 (1999)
21. Eksandh, L., B. Bakall, B. Bauer, C. Wadelius and S. Andreasson: Best's vitelliform macular dystrophy caused by a new mutation (Val89Ala) in the VMD2 gene. Ophthalmic Genet 22, 107-115 (2001)
22. Evans, K., C.Y. Gregory, S.D. Wijesuriya, S. Kermani, M.R. Jay, C. Plant and A.C. Bird: Assessment of the phenotypic range seen in Doyne honeycomb retinal dystrophy. Arch Ophthalmol 115, 904-910 (1997)
23. Fava, S., J. Azzopardi, S. Ellard and A.T. Hattersley: ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease. Diabetes Care 24, 2115-2120 (2001)
24. Felbor, U., H. Schilling and B.H. Weber: Adult vitelliform macular dystrophy is frequently associated with mutations in the peripherin/RDS gene. Hum Mutat 10, 301-309 (1997)
25. Francois, J.: [Heredity of senile macular degeneration]. Arch Ophtalmol Rev Gen Ophtalmol 29, 899-902 (1969)
26. Freund, K.B., L.A. Yannuzzi and J.A. Sorenson: Age-related macular degeneration and choroidal neovascularization. Am J Ophthalmol 115, 786-791 (1993)
27. Gorczyca, W.A., A.S. Polans, I.G. Surgucheva, I. Subbaraya, W. Baehr and K. Palczewski: Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem 270, 22029-22036 (1995)
28. Gorin, M.B., J.C. Breitner, P.T. De Jong, G.S. Hageman, C.C. Klaver, M.H. Kuehn and J.M. Seddon: The genetics of age-related macular degeneration. Mol Vis 5, 29 (1999)
29. Gorin, M.B., K.E. Jackson, R.E. Ferrell, V.C. Sheffield, S.G. Jacobson, J.D. Gass, E. Mitchell and E.M. Stone: A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. Ophthalmology 102, 246-255 (1995)
30. Gutman, F.A.: The natural course of active choroidal lesions in the presumed ocular histoplasmosis syndrome. Trans Am Ophthalmol Soc 77, 515-541 (1979)
31. Hageman, G.S., P.J. Luthert, N.H. Victor Chong, L.V. Johnson, D.H. Anderson and R.F. Mullins: An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 20, 705-732 (2001)
32. Hageman, G.S. and R.F. Mullins: Molecular composition of drusen as related to substructural phenotype. Mol Vis 5, 28 (1999)
33. Hamdi, H.K., H. Nishio, J. Tavis, R. Zielinski and A. Dugaiczyk: Alu-mediated phylogenetic novelties in gene regulation and development. J Mol Biol 299, 931-939 (2000)
34. Hamdi, H.K., J. Reznik, R. Castellon, S.R. Atilano, J.M. Ong, N. Udar, J.H. Tavis, A.M. Aoki, A.B. Nesburn, D.S. Boyer, K.W. Small, D.J. Brown and M.C. Kenney: Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. Biochem Biophys Res Commun 295, 668-672 (2002)
35. Hardcastle, A.J., D.L. Thiselton, L. Van Maldergem, B.K. Saha, M. Jay, C. Plant, R. Taylor, A.C. Bird and S. Bhattacharya: Mutations in the RP2 gene cause disease in 10% of families with familial X-linked retinitis pigmentosa assessed in this study. Am J Hum Genet 64, 1210-1215 (1999)
36. Hashimoto, M., M. Yasuda, S. Tanimukai, M. Matsui, N. Hirono, H. Kazui and E. Mori: Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease. Neurology 57, 1461-1466 (2001)
37. Hirvela, H., H. Luukinen, E. Laara, L. Sc and L. Laatikainen: Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology 103, 871-877 (1996)
38. Hool, L.C., D.F. Gray, B.G. Robinson and H.H. Rasmussen: Angiotensin-converting enzyme inhibitors regulate the Na(+)-K+ pump via effects on angiotensin metabolism. Am J Physiol 271, C172-180 (1996)
39. Hool, L.C., D.W. Whalley, M.M. Doohan and H.H. Rasmussen: Angiotensin-converting enzyme inhibition, intracellular Na+, and Na(+)- K+ pumping in cardiac myocytes. Am J Physiol 268, C366-375 (1995)
40. Hyman, L.G., A.M. Lilienfeld, F.L. Ferris, 3rd and S.L. Fine: Senile macular degeneration: a case-control study. Am J Epidemiol 118, 213-227 (1983)
41. Janka, Z., A. Juhasz, A.A. Rimanoczy, K. Boda, J. Marki-Zay and J. Kalman: Codon 311 (Cys - > Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. Mol Psychiatry 7, 110-112 (2002)
42. Jeunemaitre, X., R.P. Lifton, S.C. Hunt, R.R. Williams and J.M. Lalouel: Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1, 72-75 (1992)
43. Kajiwara, K., E.L. Berson and T.P. Dryja: Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci. Science 264, 1604-1608 (1994)
44. Kim, J.E., M.J. Tauber and R.A. Mathies: Wavelength dependent cis-trans isomerization in vision. Biochemistry 40, 13774-13778 (2001)
45. Klaver, C.C., J.J. Assink, R. van Leeuwen, R.C. Wolfs, J.R. Vingerling, T. Stijnen, A. Hofman and P.T. de Jong: Incidence and progression rates of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 42, 2237-2241 (2001)
46. Klaver, C.C., M. Kliffen, C.M. van Duijn, A. Hofman, M. Cruts, D.E. Grobbee, C. van Broeckhoven and P.T. de Jong: Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet 63, 200-206 (1998)
47. Klein, M.L., W.M. Mauldin and V.D. Stoumbos: Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch Ophthalmol 112, 932-937 (1994)
48. Klein, R., B.E. Klein and T. Franke: The relationship of cardiovascular disease and its risk factors to age- related maculopathy. The Beaver Dam Eye Study. Ophthalmology 100, 406-414 (1993)
49. Klein, R., B.E. Klein and S.C. Jensen: The relation of cardiovascular disease and its risk factors to the 5- year incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104, 1804-1812 (1997)
50. Klein, R., B.E. Klein, S.C. Jensen and S.M. Meuer: The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study [see comments]. Ophthalmology 104, 7-21 (1997)
51. Klein, R., B.E. Klein and K.L. Linton: Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 99, 933-943 (1992)
52. Klein, R., Q. Wang, B.E. Klein, S.E. Moss and S.M. Meuer: The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 36, 182-191 (1995)
53. Kochendoerfer, G.G., S. Kaminaka and R.A. Mathies: Ultraviolet resonance Raman examination of the light-induced protein structural changes in rhodopsin activation. Biochemistry 36, 13153-13159 (1997)
54. Kuehn, M.H., E.M. Stone and G.S. Hageman: Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders. Invest Ophthalmol Vis Sci 42, 3123-3129 (2001)
55. Lamb, T.D. and E.N. Pugh, Jr.: G-protein cascades: gain and kinetics. Trends Neurosci 15, 291-298 (1992)
56. Lotery, A.J., F.L. Munier, G.A. Fishman, R.G. Weleber, S.G. Jacobson, L.M. Affatigato, B.E. Nichols, D.F. Schorderet, V.C. Sheffield and E.M. Stone: Allelic variation in the VMD2 gene in best disease and age-related macular degeneration. Invest Ophthalmol Vis Sci 41, 1291-1296 (2000)
57. Mathies, R.A.: Photons, femtoseconds and dipolar interactions: a molecular picture of the primary events in vision. Novartis Found Symp 224, 70-84 (1999)
58. Miano, M.G., F. Testa, M. Strazzullo, M. Trujillo, C. De Bernardo, B. Grammatico, F. Simonelli, M. Mangino, I. Torrente, G. Ruberto, M. Beneyto, G. Antinolo, E. Rinaldi, C. Danesino, V. Ventruto, M. D'Urso, C. Ayuso, M. Baiget and A. Ciccodicola: Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa. Eur J Hum Genet 7, 687-694 (1999)
59. Milton, R.C.: The Framingham eye study. Am J Ophthalmol 88, 269 (1979)
60. Mitchell, P., W. Smith, K. Attebo and J.J. Wang: Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 102, 1450-1460 (1995)
61. Mitchell, P. and J.J. Wang: Diabetes, fasting blood glucose and age-related maculopathy: The Blue Mountains Eye Study. Aust N Z J Ophthalmol 27, 197-199 (1999)
62. Moisseiev, J., A. Alhalel, R. Masuri and G. Treister: The impact of the macular photocoagulation study results on the treatment of exudative age-related macular degeneration. Arch Ophthalmol 113, 185-189 (1995)
63. Molday, L.L., A.R. Rabin and R.S. Molday: ABCR expression in foveal cone photoreceptors and its role in stargardt macular dystrophy. Am J Ophthalmol 130, 689 (2000)
64. Moss, S.E., R. Klein, B.E. Klein, S.C. Jensen and S.M. Meuer: Alcohol consumption and the 5-year incidence of age-related maculopathy: the Beaver Dam eye study. Ophthalmology 105, 789-794 (1998)
65. Mullins, R.F., N. Aptsiauri and G.S. Hageman: Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye 15, 390-395 (2001)
66. Narain, Y., A. Yip, T. Murphy, C. Brayne, D. Easton, J.G. Evans, J. Xuereb, N. Cairns, M.M. Esiri, R.A. Furlong and D.C. Rubinsztein: The ACE gene and Alzheimer's disease susceptibility. J Med Genet 37, 695-697 (2000)
67. Ottlecz, A. and T. Bensaoula: Captopril ameliorates the decreased Na+,K(+)-ATPase activity in the retina of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 31, 1633-1641 (1996)
68. Panahloo, A., C. Andres, V. Mohamed-Ali, M.M. Gould, P. Talmud, S.E. Humphries and J.S. Yudkin: The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance? Circulation 92, 3390-3393 (1995)
69. Pauleikhoff, D. and J.M. Koch: Prevalence of age-related macular degeneration. Curr Opin Ophthalmol 6, 51-56 (1995)
70. Polans, A., W. Baehr and K. Palczewski: Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci 19, 547-554 (1996)
71. Pugh, E.N., Jr. and T.D. Lamb: Amplification and kinetics of the activation steps in phototransduction. Biochim Biophys Acta 1141, 111-149 (1993)
72. Rabb, M.F., I. Garoon and F.P. LaFranco: Myopic macular degeneration. Int Ophthalmol Clin 21, 51-69 (1981)
73. Rall, S.C., Jr., K.H. Weisgraber, T.L. Innerarity and R.W. Mahley: Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci U S A 79, 4696-4700 (1982)
74. Rigat, B., C. Hubert, F. Alhenc-Gelas, F. Cambien, P. Corvol and F. Soubrier: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86, 1343-1346 (1990)
75. Rigat, B., C. Hubert, P. Corvol and F. Soubrier: PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1) Nucleic Acids Res 20, 1433 (1992)
76. Sarks, J.P., S.H. Sarks and M.C. Killingsworth: Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2, 552-577 (1988)
77. Sarks, J.P., S.H. Sarks and M.C. Killingsworth: Evolution of soft drusen in age-related macular degeneration. Eye 8, 269-283 (1994)
78. Sarks, J.P., S.H. Sarks and M.C. Killingsworth: Evolution of soft drusen in age-related macular degeneration. Eye 8, 269-283 (1994)
79. Sarks, S.H.: The aging eye. Med J Aust 2, 602-604 (1975)
80. Sarks, S.H.: Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol 60, 324-341 (1976)
81. Sarks, S.H.: Drusen patterns predisposing to geographic atrophy of the retinal pigment epithelium. Aust J Ophthalmol 10, 91-97 (1982)
82. Sarna, T.: Properties and function of the ocular melanin - a photobiophysical view. J Photochem Photobiol B 12, 215-258 (1992)
83. Schmidt, S., A.M. Saunders, M.A. De La Paz, E.A. Postel, R.M. Heinis, A. Agarwal, W.K. Scott, J.R. Gilbert, J.G. McDowell, A. Bazyk, J.D. Gass, J.L. Haines and M.A. Pericak-Vance: Association of the Apolipoprotein E gene with age-related macular degeneration: Possible effect modification by family history, age, and gender. Mol Vis 6, 287-293 (2000)
84. Shastry, B.S. and M.T. Trese: Evaluation of the peripherin/RDS gene as a candidate gene in families with age-related macular degeneration. Ophthalmologica 213, 165-170 (1999)
85. Shroyer, N.F., R.A. Lewis, A.N. Yatsenko, T.G. Wensel and J.R. Lupski: Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. Hum Mol Genet 10, 2671-2678 (2001)
86. Siegel, G.J., B.W. Agranoff, R.W. Albers and P.B. Molinoff. Basic Neurochemistry. Molecular, Cellular, and Medical Aspects. Raven Press, New York (1994)
87. Smith, W., J. Assink, R. Klein, P. Mitchell, C.C. Klaver, B.E. Klein, A. Hofman, S. Jensen, J.J. Wang and P.T. de Jong: Risk factors for age-related macular degeneration: Pooled findings from three continents. Ophthalmology 108, 697-704 (2001)
88. Smith, W., P. Mitchell and S.R. Leeder: Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol 114, 1518-1523 (1996)
89. Sorbi, S., P. Forleo, A. Tedde, E. Cellini, M. Ciantelli, S. Bagnoli and B. Nacmias: Genetic risk factors in familial Alzheimer's disease. Mech Ageing Dev 122, 1951-1960 (2001)
90. Souied, E.H., P. Benlian, P. Amouyel, J. Feingold, J.P. Lagarde, A. Munnich, J. Kaplan, G. Coscas and G. Soubrane: The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol 125, 353-359 (1998)
91. Spaide, R.F.: Choroidal neovascularization in younger patients. Curr Opin Ophthalmol 10, 177-181 (1999)
92. Stone, E.M., A.J. Lotery, F.L. Munier, E. Heon, B. Piguet, R.H. Guymer, K. Vandenburgh, P. Cousin, D. Nishimura, R.E. Swiderski, G. Silvestri, D.A. Mackey, G.S. Hageman, A.C. Bird, V.C. Sheffield and D.F. Schorderet: A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet 22, 199-202 (1999)
93. Stone, E.M., V.C. Sheffield and G.S. Hageman: Molecular genetics of age-related macular degeneration. Hum Mol Genet 10, 2285-2292 (2001)
94. Sullivan, L.S., J.R. Heckenlively, S.J. Bowne, J. Zuo, W.A. Hide, A. Gal, M. Denton, C.F. Inglehearn, S.H. Blanton and S.P. Daiger: Mutations in a novel retina-specific gene cause autosomal dominant retinitis pigmentosa. Nat Genet 22, 255-259 (1999)
95. Sunness, J.S., N.M. Bressler, Y. Tian, J. Alexander and C.A. Applegate: Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci 40, 1761-1769 (1999)
96. Sunness, J.S., N.M. Bressler, Y. Tian, J. Alexander and C.A. Applegate: Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci 40, 1761-1769 (1999)
97. Sunness, J.S., J. Gonzalez-Baron, C.A. Applegate, N.M. Bressler, Y. Tian, B. Hawkins, Y. Barron and A. Bergman: Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology 106, 1768-1779 (1999)
98. Sunness, J.S., J. Gonzalez-Baron, C.A. Applegate, N.M. Bressler, Y. Tian, B. Hawkins, Y. Barron and A. Bergman: Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology 106, 1768-1779 (1999)
99. Sunness, J.S., J. Gonzalez-Baron, N.M. Bressler, B. Hawkins and C.A. Applegate: The development of choroidal neovascularization in eyes with the geographic atrophy form of age-related macular degeneration. Ophthalmology 106, 910-919 (1999)
100. Sunness, J.S., G.S. Rubin, C.A. Applegate, N.M. Bressler, M.J. Marsh, B.S. Hawkins and D. Haselwood: Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology 104, 1677-1691 (1997)
101. Takezako, T., K. Saku, B. Zhang, J. Ou, H. Bai, K. Imai, S. Jimi, K. Shirai and K. Arakawa: Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris. Am J Hypertens 12, 291-297 (1999)
102. Tombran-Tink, J., S.M. Shivaram, G.J. Chader, L.V. Johnson and D. Bok: Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 15, 4992-5003 (1995)
103. Vingerling, J.R., I. Dielemans, A. Hofman, D.E. Grobbee, M. Hijmering, C.F. Kramer and P.T. de Jong: The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology 102, 205-210 (1995)
104. Wang, Q., R.J. Chappell, R. Klein, A. Eisner, B.E. Klein, S.C. Jensen and S.E. Moss: Pattern of age-related maculopathy in the macular area. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 37, 2234-2242 (1996)
105. Weisgraber, K.H., S.C. Rall, Jr. and R.W. Mahley: Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem 256, 9077-9083 (1981)
106. Young, R.W.: Visual cells and the concept of renewal. Invest Ophthalmol Vis Sci 15, 700-725 (1976)