Cerium(III)-catalyzed cyclizations with 1-cyanomethylene tetrahydroisoquinoline: Substituent controlled formation of fused pyrroles or pyridines

Synlett

Volumn , Issue 6, 2004, Pages 1023-1026

  Vincze, Zoltán ^a   Nemes, Péter ^a   Balázs, Barbara ^b   Tóth, Gábor ^b,c   Scheiber, Pál ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^c TEVA PHARMACEUTICALS   (Israel)

Author keywords

Benzo a quinolizines; Cerium(III) chloride; Cyclization; Pyrrolo 2,1 a isoquinolines; enaminonitrile

Indexed keywords

1 CYANOMETHYLENE TETRAHYDROISOQUINOLINE; CERIUM; ISOQUINOLINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; QUANTUM YIELD; REACTION ANALYSIS; SUBSTITUTION REACTION;

EID: 3142746646     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-822904     Document Type: Article

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13. 2. The combined solutions were concentrated under reduced pressure, and the crude product was purified by flash chromatography (hexane-EtOAc. 5:1).
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15. 2. The filtered extracts were concentrated under reduced pressure, and then the crude product was purified by flash chromatography (hexane-EtOAc, 5:1).