Cardiac allograft tolerance induced by intra-arterial infusion of recombinant adenoviral CTLA4Ig

Transplantation

Volumn 67, Issue 12, 1999, Pages 1517-1523

  Yang, Zandong ^a   Rostami, Susan ^a   Koeberlein, Brigitte ^a   Barker, Clyde F ^a   Naji, Ali ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ADENOVIRUS; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART MUSCLE; HEART TRANSPLANTATION; IMMUNOMODULATION; INTRAARTERIAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; AORTA; EVALUATION STUDIES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOCONJUGATES; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRA-ARTERIAL; LAC OPERON; RATS; RATS, INBRED BN; RATS, INBRED LEW; RECOMBINANT FUSION PROTEINS;

EID: 0033050759     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199906270-00004     Document Type: Article

References (39)

1. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med 1990; 322: 510.
2. Charlton B, Auchincloss H, Fathman CG. Mechanisms of transplantation tolerance. Annu Rev Immunol 1994; 12: 707.
3. Thompson CB, Allison JP. The emerging role of CTLA4 as an immune attenuator. Immunity 1997; 7: 445.
4. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996; 14: 233.
5. Pearson T, Alexander DZ, Corbascio M, et al. Analysis of the B7 costimulatory pathway in allograft rejection. Transplantation 1997; 63: 1463.
6. Baliga P, Chavin KD, Qin L, et al. CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity. Transplantation 1994; 58: 1082.
7. Lenschow DJ, Zeng Y, Thistlethwaite JR, et al. Long-term survival of xenogeneic pancreatic islet graft induced by CTLA4Ig. Science 1992; 257: 789.
8. Russell ME, Hancock WW, Akalin E, et al. Chronic cardiac rejection in the Lew to F344 rat model. J Clin Invest 1996; 97: 833.
9. Pearson TC, Alexander DZ, Winn KJ, Linsley PS, Lowry RP, Larsen CP. Transplantation tolerance induced by CTLA4-Ig. Transplantation 1994; 57: 1701.
10. Steurer W, Nickerson PW, Steele AW, Steiger J, Zheng XX, Strom TB. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. J Immunol 1995; 155: 1165.
11. Roy-Chaudhury P, Nickerson PW, Manfro RC, et al. CTLA4Ig attenuates accelerated rejection (presensitization) in the mouse islet allograft model. Transplantation 1997; 64: 172.
12. Matsumura Y, Zuo XJ, Prehn J, et al. Soluble CTLA4Ig modifies parameters of acute inflammation in rat lung allograft rejection without altering lymphocytic infiltration or transcription of key cytokines. Transplantation 1995; 59: 551.
13. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
14. Odorico JS, Barker CF, Posselt AM, Naji A. Induction of donor-specific tolerance to rat cardiac allografts by intrathymic inoculation of bone marrow. Surgery 1992; 112: 370.
15. Billingham RE, Medawar PB. The technique of free skin grafting in mammals. J Exp Biol 1951; 28: 385.
16. Bluestone JA. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 1995; 2: 555.
17. Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71: 1065.
18. Lee J, Laks H, Drinkwater DC, et al. Cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in the transplanted mouse heart. J Thorac Cardiovasc Surg 1996; 111: 246.
19. Brauner R, Nonoyama M, Laks H, et al. Intracoronary adenovirus-mediated transfer of immunosuppressive cytokine gene prolongs allograft survival. J Thorac Cardiovasc Surg 1997; 114: 923.
20. Ardehali A, Fyfe A, Laks H, Drinkwater DC, Qia JH, Lusis A. Direct gene transfer into donor hearts at the time of harvest. J Thorac Cardiovasc Surg 1995; 109: 716.
21. Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N, Verma IM. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 1995; 92: 1401.
22. DeMatteo RP, Chu G, Ahn M, Chang E, Barker CF, Markmann JF. Long-lasting adenovirus transgene expression in mice through neonatal intrathymic tolerance induction without the use of immunosuppression. J Virol 1997; 71: 5330.
23. DeMatteo RP, Raper SE, Ahn M, et al. Gene transfer to the thymus: a means of abrogating the immune response to recombinant adenovirus. Ann Surg 1995; 222: 229.
24. DeMatteo RP, Markmann JF, Kozarsky KF, Barker CF, Raper SE. Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Ther 1996; 3: 4.
25. Fang B, Eisensmith RC, Wang H, et al. Gene therapy for Hemophilia B: host immunosuppression prolongs the therapeutic effect of Adenovirus-mediated Factor IX expression. Hum Gene Ther 1995; 6: 1039.
26. Kay MA, Meuse L, Gown AM, et al. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci USA 1997; 94: 4686.
27. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA 1994; 91: 6196.
28. Brauner R, Wu L, Laks H, et al. Intracoronary gene transfer of immunosuppressive cytokines to cardiac allografts: method and efficacy of adenovirus-mediated transduction. J Thorac Cardiovasc Surg 1997; 113: 1059.
29. Kay MA, Holterman AX, Meuse L, et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet 1995; 11: 191.
30. Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 1996; 93: 13967.
31. Groenewegen G, Buurman WA, Jeunhomme GM. Alloantigen presentation by canine endothelial cells. Presentation of autologous alloantigens in vitro. Transplantation 1986; 42: 751.
32. Wagner CR, Vetto RM, Burger DR. The mechanism of antigen presentation by endothelial cells. Immunobiology 1984; 168: 453.
33. Pober JS, Gimbrone MA, Collins T, et al. Interactions of T lymphocytes with human vascular endothelial cells: role of endothelial cells surface antigens. Immunobiology 1984; 168: 483.
34. Larsen CP, Morris PJ, Austyn JM. Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel pathway for initiation of rejection. J Exp Med 1990; 171: 307.
35. Strom TB, Roy-Chaudhury P, Manfro R, et al. The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol 1996; 8: 688.
36. Thompson CB. Distinct role for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell 1995; 81: 979.
37. Woodward JE, Bayer AL, Chavin KD, Blue ML, Baliga P. T-cell alteration in cardiac allograft recipients after B7 (CD80 and CD86) blockade. Transplantation 1998; 66: 14.
38. Olthoff KM, Judge TA, Gelman AE, et al. Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med 1998; 4: 194.
39. Nickoloff BJ, Mitra RS, Lee K, et al. Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. Am J Pathol 1993; 142: 1029.