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Volumn 305, Issue 5682, 2004, Pages 350-352

Completing the view of transcriptional regulation

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DOUBLE STRANDED DNA; BACTERIAL DNA; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; LACI PROTEIN, BACTERIA; REPRESSOR PROTEIN;

EID: 3142723254     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101270     Document Type: Review
Times cited : (50)

References (20)
  • 1
    • 0029938053 scopus 로고    scopus 로고
    • M. Lewis et al., Science 271, 1247 (1996).
    • (1996) Science , vol.271 , pp. 1247
    • Lewis, M.1
  • 3
    • 3142687968 scopus 로고    scopus 로고
    • note
    • Wild-type lac repressor exists as a tetramer, but the "head-groups" of only two subunits at a time bind to an operator or nonspecific DNA site, and only these DNA binding domains of the repressor have an important role in the DNA-protein interaction. Hence, the dimer of DNA binding domains studied here provides a valid representation of the interactions of the repressor molecule with dsDNA for both the RO and the RD complexes.
  • 6
    • 0004219679 scopus 로고
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
    • J. R. Beckwith, D. Zipser, Eds., The Lactose Operon (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1970).
    • (1970) The Lactose Operon
    • Beckwith, J.R.1    Zipser, D.2
  • 18
    • 3142674702 scopus 로고    scopus 로고
    • note
    • This so-called one-dimensional diffusion is not-indeed cannot be-faster than three-dimensional diffusion in free solution. Instead, one-dimensional diffusion speeds target location by reducing the volume of the solution that must be searched, rather than by increasing the rate of the searching process itself.
  • 20
    • 3142680631 scopus 로고    scopus 로고
    • note
    • Supported by NIH grants GM-15792 and GM-29158. P.H.v.H. is an American Cancer Society Research Professor of Chemistry.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.