The β-glucuronyl-based prodrug strategy allows for its application on β-glucuronyl-platinum conjugates

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 16, 2004, Pages 4273-4276

  Tromp, Reynier A ^a   Van Boom, Stella S G E ^a   Timmers, C Marco ^a   Van Zutphen, Steven ^a   Van Der Marel, Gijsbert A ^a   Overkleeft, Herman S ^a   Van Boom, Jacques H ^a   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Glucuronidase; ADEPT; Anticancer drugs; Glucuronide prodrugs; Platinum; PMT; Prodrug therapy

Indexed keywords

GLUCURONIC ACID; PLATINUM COMPLEX; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; DRUG DESIGN; DRUG SYNTHESIS; ENZYMATIC DEGRADATION; TUMOR CELL;

GLUCURONIDASE; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; PLATINUM COMPOUNDS; PRODRUGS;

EID: 3142721150     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.015     Document Type: Article

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25. +=737
26. 1H NMR spectrum was taken immediately
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