Synthesis of quaternised 2-aminopyrimido[4,5-d]pyrimidin-4(3H)-ones and their biological activity with dihydrofolate reductase

European Journal of Medicinal Chemistry

Volumn 38, Issue 7-8, 2003, Pages 719-728

  Gebauer, Markus G ^a,b   McKinlay, Carolyn ^a,c   Gready, Jill E ^a  

^a Australian National University   (Australia)

^b REPATRIATION GENERAL HOSPITAL   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Alkyl pyrimido 4,5 d pyrimidine; Antifolate; Dihydrofolate reductase; Pterin; Substrates

Indexed keywords

2 AMINOPYRIMIDO[4,5 D]PYRIMIDIN 4(3H) ONE; 2,4 DIAMINO 3 METHYLIMINOMETHYLPYRIMIDIN 6(1H) ONE; 6 METHYL 2 AMINOPYRIMIDO[4,5 D]PYRIMIDIN 4(6H) ONE; 8 ETHYL 2 AMINOPYRIMIDO[4,5 D]PYRIMIDIN 4(8H) ONE; 8 METHYL 2 AMINOPYRIMIDO[4,5 D]PYRIMIDIN 4(8H) ONE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHYL IODIDE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; CHEMICAL BOND; CHICKEN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; HYDRATION; METHYLATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; RING OPENING; ULTRAVIOLET SPECTROSCOPY;

EID: 0042657901     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00140-5     Document Type: Article

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