Mechanisms of obesity-related hypertension

Hormone and Metabolic Research

Volumn 36, Issue 6, 2004, Pages 376-380

  Lamounier Zepter, V ^a,b   Bornstein, S R ^a   Ehrhart Bornstein, M ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Adipose tissue; Adrenal; Aldosterone; Overweight

Indexed keywords

INSULIN; LEPTIN;

ADIPOSE TISSUE; ADRENAL CORTEX; ADRENERGIC SYSTEM; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; EPIDEMIC; ETHNOLOGY; HUMAN; HYPERINSULINEMIA; HYPERTENSION; HYPOTHALAMUS; INDUSTRIALIZATION; INSULIN RESISTANCE; KIDNEY TUBULE ABSORPTION; METABOLIC DISORDER; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RACE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SOCIOECONOMICS; SYMPATHETIC TONE; VASODILATATION; WEIGHT GAIN;

ADIPOSE TISSUE; ADRENAL GLANDS; ALDOSTERONE; FATTY ACIDS; HUMANS; HYPERTENSION; HYPOTHALAMUS; LIVER; MINERALOCORTICOIDS; OBESITY; SYMPATHETIC NERVOUS SYSTEM;

EID: 3142695446     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-814583     Document Type: Conference Paper

References (55)

1. World Health Organization. Obesity - preventing and managing the global epidemic: report of a WHO consultation on obesity. Geneva: WHO, 1998
2. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002; 288: 1723-1727
3. World Health Organization. MONICA Project. Geographical variation in the major risk factors of coronary heart disease in men and women aged 35-64 years. World Health Stat Quart 1988; 41: 115-140
4. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643
5. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studies cohort of U.S. adults. N Engl J Med 2003; 348: 1625-1638
6. Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone. Theory and therapy. Hypertension 2004; 43: 1-7
7. Cooper RS, Rotimi CN, Ward R. The puzzle of hypertension in African-Americans. Sci Am 1999; 280: 56-63
8. Jones DW, Kim JS, Andrew ME, Kim SJ, Hong YP. Body mass index and blood pressure in Korean men and women: the Korean National Blood Pressure Survey. J Hypertens 1994; 12: 1433-1437
9. Doll S, Paccaud F, Bovet P et al. Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries. Int. J Obes Relat Metab Disord 2002; 26: 48-57
10. Garrison RJ, Kannel WB, Stokes J, Castelli WP. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med 1987; 16: 235-251
11. Miller ER, Erlinger TP, Young DR, Jehn M, Charleston J, Rhodes D, Wasan SK, Appel LJ. Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT). Hypertension 2002; 40: 612-618
12. He J, Whelton PK, Appel JL, Chalerston J, Klag MJ. Long-term effects of weight loss and dietary sodium reduction on incidence of hypertension. Hypertension 2000; 35: 544-549
13. Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J. Impact of the obesity epidemic on hypertension and renal disease. Curr Hypertens Rep 2003; 5: 386-392
14. Tuck ML. Obesity, the sympathetic nervous system, and essential hypertension. Hypertension 1992; 19: 167-177
15. Masuo K. Obesity-related hypertension: role of the sympathetic nervous system, insulin, and leptin. Curr Hypertens Rep 2002; 4: 112-118
16. Engeli S, Sharma AM. The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension. J Mol Med 2001; 79: 21-29
17. Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, Ye L, Thompson P, Shou Y, O'Shaughnessy K, Ronco P, Brown J. PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. FASEB J 2003; 17: 1966-1968
18. Troisi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L. Relation of obesity and diet to sympathetic nervous system activity. Hypertension 1991; 17: 669-677
19. Scherrer U, Randin D, Tappy L, Vollenweider P, Jequier E, Nicod P. Body fat and sympathetic nerve activity in healthy subjects. Circulation 1994; 89: 2634-2640
20. Grassi U, Seravalle G, Cattaneo BM, Bolla GB, Lanfranchi A, Colombo M, Giannattasio C, Brunani A, Cavagnini F, Mancia G. Sympathetic activation in obese normotensive subjects. Hypertension 1995; 25: 560-563
21. Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 1997; 96: 3423-3429
22. Rumantir MS, Vaz M, Jennings GL, Collier G, Kaye DM, Seals DR, Wiesner GH, Brunner-La Rocca, HP , Esler MD. Neural mechanisms in human obesity-related hypertension. J Hypertens 1999; 17: 1125-1133
23. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995; 25: 893-897
24. Jequier E. Leptin signaling, adiposity, and energy balance. Ann NY Acad Sci 2002; 967: 379-388
25. Torpy DJ, Bornstein SR, Chrousos GP. Leptin and interleukin-6 in sepsis. Horm Metab Res 1998; 30: 726-729
26. Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Leptin inhibits cortisol release directly. Diabetes 1997; 46: 1235-1238
27. Lembo G, Vecchione C, Fratta L, Marino G, Trimarco V, d'Amati G, Trimarco B. Leptin induces direct vasodilatation through distinct endothelial mechanisms. Diabetes 2000; 49: 293-297
28. Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G, Gentile MT, Fratta L, Trimarco V, Trimarco B, Lembo G. Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002; 51: 168-173
29. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31: 409-414
30. Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 2002; 39: 496-501
31. Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, Matsuoka N, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Nakao K. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 2000; 105: 1243-1252
32. Hall JE. Pathophysiology of obesity hypertension. Curr Hypertens Rep 2000; 2: 139-147
33. Rocchini AP. Obesity hypertension, salt sensitivity and insulin resistance. Nutr Metab Cardiovasc Dis 2000; 10: 287-294
34. Cooper R, McFarlane-Anderson N, Bennet FI, Wilks R, Puras A, Tewksbury D, Ward R, Forrester T. ACE, angiotensinogen and obesity: a potential pathway leading to hypertension. J Hum Hypertens 1997; 11: 107-111
35. Umemura S, Nyui N, Tamura K, Hibi K, Yamaguchi S, Nakamaru M, Ishigami T, Yabana M, Kihara M, Inoue S, Ishii M. Plasma angiotensinogen concentrations in obese patients. Am J Hypertens 1997; 10: 629-633
36. Licata G, Scaglione R, Ganguzza A, Corrao S, Donatelli M, Parrinello G, Dichiara MA, Merlino G, Cecala MG. Central obesity and hypertension: relationship between fasting serum insulin, plasma renin activity, and diastolic blood pressure in young obese subjects. Am J Hypertens 1994; 7: 314-320
37. Egan BM, Stepniakowski K, Goodfriend TL. Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering. Am J Hypertens 1994; 7: 886-893
38. Stowasser M, Gunasekera TG, Gordon RD. Familial varieties of primary aldosteronism. Clin Exp Pharmacol Physiol 2001; 28: 1087-1090
39. Goodfriend TL, Egan BM, Kelley DE. Aldosterone in obesity. Endocr Res 1998; 24: 789-796
40. Rocchini AP, Katch VL, Grekin R, Moorehead C, Anderson J. Role for aldosterone in blood pressure regulation of obese adolescents. Am J Cardiol 1986; 57: 613-618
41. El Gharbawy AH, Nadig VS, Kotchen JM, Grim CE, Sagar KB, Kaldunski M, Hamet P, Pausova Z, Gaudet D, Gossard F et al. Arterial pressure, left ventricular mass, and aldosterone in essential hypertension. Hypertension 2001; 37: 845-850
42. Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ. Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 1999; 7: 355-362
43. Thakur V, Richards R, Reisin E. Obesity, hypertension, and the heart. Am J Med Sci 2001; 321: 242-248
44. Paula RB, Silva AA, Hall JE. Aldosterone antagonism attenuates obesity-induces hypertension and glomerular hyperfiltration. Hypertension 2004; 43: 1-7
45. He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Dietary sodium intake and incidence of congestive heart failure in overweight US men and women: first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Arch Intern Med 2002; 162: 1619-1624
46. He J, Ogden LG, Vupputuri S, Bazzano LA, Loria C, Whelton PK. Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults. JAMA 1999; 282: 2027-2034
47. Dessi-Fulgheri P, Sarzani R, Tamburrini P, Moraca A, Espinosa E, Cola G, Giantomassi L, Rappelli A. Plasma atrial natriuretic peptide and natriuretic peptide receptor gene expression in adipose tissue of normotensive and hypertensive obese patients. J Hypertens 1997; 15: 1695-1699
48. Goodfriend TL, Ball DL, Gardner HW. An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. Prostaglandins Leukot Essent Fatty Acids 2002; 67: 163-167
49. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, Hauner H, McCann SM, Scherbaum WA, Bornstein SR. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci USA 2003; 100: 14211-14216
50. Massiéra F, Bloch-Faure M, Ceiler D, Murakami K, Fukamizu A, Gasc JM, Quignard-Boulangé A, Negrel R, Ailhaud G, Seydoux J, Meneton P, Teboul M. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB 2001; 15: 2727-2729
51. Frossard PM, Parvez SH, Lestringant GG, Kureshi NS. Associations between the human insulin gene 5′ VNTR and clinical variables of the renin-angiotensin system. Neuroendocrinol Lett 2003; 24: 325-328
52. Cooper RS, Gui X, Rotimi CN, Luke A, Ward R, Adeyemo A, Danilov SM. Heritability of angiotensin-converting enzyme and angiotensinogen. A comparison of US blacks and nigerians. Hypertension 2000; 35: 1141-1147
53. Kim S, Moustaid-Moussa N. Secretory, endocrine and autocrine/paracrine function of the adipocyte. J Nutr 2000; 13: 3110S-3115S
54. Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60: 329-339
55. Vrezas I, Wentworth P, Bornstein SR. Myelolipomatous foci on an adrenal adenoma causing Cushing's syndrome. Endocr Res 2003; 29: 67-71