Electrospray ionization mass spectrometric characterization and quantitation of xanthine derivatives using isotopically labelled analogues: An application for equine doping control analysis

Rapid Communications in Mass Spectrometry

Volumn 18, Issue 14, 2004, Pages 1553-1560

  Thevis, Mario ^a   Opfermann, Georg ^a   Krug, Oliver ^a   Schänzer, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BODY FLUIDS; CAFFEINE; DEUTERIUM; DISSOCIATION; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE INTERFACES; PHASE SEPARATION; POTASH;

CONTROL LABORATORY; DOPING CONTROL; DOPING CONTROL ANALYSIS; HORSE URINE; ISOTOPE DILUTION MASS SPECTROMETRY; ISOTOPICALLY LABELED; LABORATORY ANALYSIS; PERFORMANCE ENHANCING; SYNTHESISED; THRESHOLD LEVELS;

ELECTROSPRAY IONIZATION;

ACETONITRILE; CAFFEINE; DEUTERIUM; ILLICIT DRUG; ISOTOPE; METHYL IODIDE; N METHYL N TRIMETHYLSILYLTRIFLUOROACETAMIDE; POTASSIUM CARBONATE; THEOBROMINE; TRIFLUOROACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; ATMOSPHERIC PRESSURE; ATMOSPHERIC PRESSURE IONIZATION; DISSOCIATION; DOPING; DRUG CONTROL; DRUG DETERMINATION; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; ELECTROSPRAY MASS SPECTROMETRY; EQUINE DOPING; HORSE; IONIZATION; ISOTOPE DILUTION ASSAY; ISOTOPE DILUTION MASS SPECTROMETRY; ISOTOPE LABELING; LABORATORY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUADRUPOLE MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 3142694731     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1518     Document Type: Article

References (30)

1. Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM. Science 1989; 246: 64.
2. Hurst WJ, Tarka SM, Powis TG, Valdez F, Hester TR. Nature 2002; 418: 289.
3. Schneider H, Ma L, Glatt H. J. Chromatogr. B 2003; 789: 227.
4. Rao GS, Khanna KL, Cornish HH. J. Pharm. Sci. 1972; 61: 1822.
5. Midha KK, Sved S, Hossie RD, McGilveray IJ. Biomed. Mass Spectrom. 1977; 4: 172.
6. Sinclair CJD, Geiger JD. J. Sports Med. Phys. Fitness 2000; 40: 71.
7. Pasman WJ, van Baak MA, Jeukendrup AE, de Haan A. Int. J. Sports Med. 1995; 16: 225.
8. Fisher SM, McMurray RG, Berry M, Mar MH, Forsythe WA. Int. J. Sports Med. 1986; 7: 276.
9. Juhn M. Sports Med. 2003; 33: 921.
10. Veterinary Regulations; Federation Equestre Internationale: Lausanne, 2002.
11. Houghton E. Biomed. Mass Spectrom. 1982; 9: 103.
12. Kress M, Meißner D, Kaiser P, Hanke R, Wood WG. Clin. Lab. 2002; 48: 535.
13. Cawley AT, Trout G, Kazlauskas R. In Recent Advances in Doping Analysis, Schänzer W, Geyer H, Gotzmann A, Mareck U (eds). Sport&Buch Strauß: Cologne, 2001; 229.
14. Delbeke FT, De Backer P. J. Chromatogr. B 1996; 687: 247.
15. Georga KA, Samanidou VF, Papadoyannis IN. J. Chromatogr. B 2001; 759: 209.
16. Kress M, Meißner D, Kaiser P, Hanke R, Wood WG. Clin. Lab. 2002; 48: 541.
17. Bispo MS, Veloso MCC, Pinheiro HLC, De Oliveira RFS, Reis JON, De Andrade JB. J. Chromatogr. Sci. 2002; 40: 45.
18. Hieda Y, Kashimura S, Hara K, Kageura M. J. Chromatogr. B 1995; 667: 241.
19. Traube W. Ber. 1900; 33: 1371.
20. Bredereck H, v. Schuh H-G, Martini A. Chem. Ber. 1950; 83: 201.
21. Lehmann G, Martinod P. Arzneimittelforschung 1967; 17: 35.
22. Bills CW, Gebura SE, Meek JS, Sweeting OJ. J. Org. Chem. 1962; 27: 4633.
23. Traube W. Ber. 1900; 33: 3035.
24. Müller CE, Shi D, Manning M, Daly JW. J. Med. Chem. 1993; 36: 3341.
25. Dünges W. Chromatographia 1973; 6: 196.
26. Garst JE, Kramer GL, Wu YJ, Wells JN. J. Med. Chem. 1976; 19: 499.
27. EURACHEM (1st edn). Available: http://www.eurachem.ul. pt/guides/valid.pdf, 1998; vol. 2003.
28. Kromidas A. Validierung in der Analytik, Wiley-VCH: Weinheim, 1999.
29. Waters. Application Note, 2003.
30. Nicolau C, Hildenbrand K. Z. Naturforsch. 1974; 29: 475.