Negative growth control of renal cell carcinoma cell by connexin 32: Possible involvement of Her-2

Molecular Carcinogenesis

Volumn 40, Issue 3, 2004, Pages 135-142

  Fujimoto, Eriko ^a   Satoh, Haruna ^b   Negishi, Etsuko ^a   Ueno, Koichi ^a   Nagashima, Yoji ^c   Hagiwara, Kiyokazu ^b   Yamasaki, Hiroshi ^d   Yano, Tomohiro ^b  

^a CHIBA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d KWANSEI GAKUIN UNIVERSITY   (Japan)

Author keywords

Connexin 32; Contact inhibition; Her 2; Negative growth control; Renal cell carcinoma

Indexed keywords

CONNEXIN 32; EPIDERMAL GROWTH FACTOR RECEPTOR 2; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DENSITY; CELL GROWTH; CELL SPECIFICITY; CONTACT INHIBITION; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GROWTH RATE; GROWTH REGULATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; STEM CELL;

ANIMALS; CARCINOMA, RENAL CELL; CELL COUNT; CELL DIVISION; CONNEXINS; CONTACT INHIBITION; G1 PHASE; GAP JUNCTIONS; HUMANS; KIDNEY NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; RECEPTOR, ERBB-2; RNA, SMALL INTERFERING; S PHASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 3142676384     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.20025     Document Type: Article

References (34)

1. Mesnil M, Yamasaki H. Cell-cell communication and growth control of normal and cancer cells: Evidence and hypothesis. Mol Carcinogenesis 1993;7:14-17.
2. Saez JC, Connor JA, Spray DC, Bennett MVL. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-triphosphate and calcium ions. Proc Natl Acad Sci USA 1989;86:2708-2712.
3. Simpson I, Rose B, Lowenstein WR. Size limit of molecule permeating the junctional membrane channels. Science 1977;195:294-296.
4. Stauffer KA, Kumar NM, Gilula NB, Unwin N. Isolation and purification of gap junction channels. J Cell Biol 1991;115:141-150.
5. Paul DL. New functions for gap junctions. Curr Opin Cell Biol 1995;7:665-672.
6. Willecke K, Eiberger J, Degen J, et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 2002;383:725-737.
7. Fitzgerald DJ, Yamasaki H. Tumor promotion: Models and assay systems. Teratog Carcinog Mutagen 1990;10:89-102.
8. Martin W, Zempel G, Hulser D, Willecke K. Growth inhibition of oncogene-transformed rat fibloblasts by cocultured normal cells: Relevance of metabolic cooperation mediated by gap junctions. Cancer Res 1991;51:5348-5351.
9. Trosko JE, Madhukar BV, Chang CC. Endogenous and exogenous modulation of gap junctional intercellular communication: Toxicological and pharmacological implications. Life Sci 1993;53:1-19.
10. Yamasaki H, Naus CCG. Role of connexin genes in growth control. Carcinogenesis 1996;17:1199-1213.
11. Martyn KD, Kurata WE, Warn-Cramer BJ, Burt JM, TenBroek E, Lau AF. Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype. Cell Growth Differ 1997;8:1015-1027.
12. Rae RS, Mehta PP, Chang CC, Trosko JE, Ruch RJ. Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin32. Mol Carcinogenesis 1998;22:120-127.
13. Bond SL, Bechberger JF, Khoo NK, Naus CC. Transfection of C6 glioma cells with connexin32: The effects of expression of a nonendogenous gap junction protein. Cell Growth Differ 1994;5:179-186.
14. Mesnil M, Krutovskikh C, Piccoli C, et al. Negative growth control of HeLa cells by conneixn genes: Connexin species specificity. Cancer Res 1995;55:629-639.
15. Yano T, Hernandez-Blazquez FJ, Omori Y, Yamasaki H. Reduction of malignant phenotype of HepG2 cell is associated with the expression of connexin26 but not connexin32. Carcinogenesis 2001;22:1593-1600.
16. Yano T, Ito F, Satoh H, et al. Tumor-suppressive effect of connexin32 in renal cell carcinoma from maintenance hemodialysis patients. Kidney Int 2003;63:381.
17. Hirai A, Yano T, Nishikawa K, et al. Down-regulation of connexin32 gene expression through DNA methylation in a human renal cell carcinoma cell. Am J Nephrol 2003;23:172-177.
18. Kumar NM, Gilula NB. Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein. J Cell Biol 1986;103:767-776.
19. Omori Y, Yamasaki H. Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails. Carcinogenesis 1999;20:1913-1918.
20. Ciardiello F, Caputo R, Bianco R, et al. Cooperative inhibition of renal cancer growth by anti-EGF receptor antibody and protein kinase A antisense oligonucleotide. J Natl Cancer Inst 1998;90:1087-1094.
21. Brissette JL, Kumar NM, Gilula NB, Hall JE, Dotto GP. Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation. Proc Natl Acad Sci USA 1994;91:6453-6457.
22. Yano T, Zissel G, Muller-Qernhein J, Shin SJ, Satoh H, Ichikawa T. Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3. FEBS Lett 2002;518:154-158.
23. Kumar NM, Gilula NB. The gap junction communication channel. Cell 1996;84:381-386.
24. Sherr CJ. Cancer cell cycles. Science 1996;274:1672-1677.
25. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
26. Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 2000;19:3159-3167.
27. Riese DJ, Stern DF. Specificity within the EGF family/ErbB receptor family signaling network. BioEssays 1998;20:41-48.
28. Di Marco E, Pierce JH, Knicley CL, Di Fiore PP. Transformation of NIH3T3 cells by overexpression of the normal coding sequence of the rat neu gene. Mol Cell Biol 1990;10:3247-3252.
29. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 2001;3:785-792.
30. Kojima T, Sawada N, Chiba H, et al. Induction of tight junctions in human connexin32-transfected mouse hepatocytes: Connexin32 interacts with occludin. Biochem Biophys Res Commun 1999;266:222-229.
31. Kojima T, Spray D, Kokai H, Chiba H, Mochizuki Y, Sawada N. Cx32 formation and/or cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line. Exp Cell Res 2002;276:40-51.
32. Yano T, Mesnil M, Yamasaki H. Study on the role of connexin genes as tumor suppressor and development of a new cancer therapy mediated by the genes. Rep Jpn Hum Sci Found 2002;1:64-68.
33. Plotkin LI, Manolagas SC, Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 2002;277:8648-8657.
34. Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. Tyrosine kinase signaling in breast cancer: Epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res 2000;2:203-210.