Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA

Inflammation

Volumn 28, Issue 2, 2004, Pages 59-65

  Eckey, Rolf ^a   Menschikowski, Mario ^a   Peter, ^a,b   Jaross, Werner ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b Lattke ^*

Author keywords

cholesterol; inflammation; phospholipase A2; transgenic mice

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPASE A2; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; AUTOPSY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEEDING; HEART MUSCLE; KIDNEY HOMOGENATE; KIDNEY PARENCHYMA; LIPID TRANSPORT; LIVER HOMOGENATE; MALE; MEASUREMENT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SPLEEN; TISSUE; TISSUE HOMOGENATE; TRANSGENIC MOUSE;

ANIMALS; CHOLESTEROL, DIETARY; FEEDING BEHAVIOR; GENE EXPRESSION; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOLIPASES A; TRIGLYCERIDES;

ANIMALIA; MUS MUSCULUS;

EID: 3142668903     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:IFLA.0000033021.44105.9c     Document Type: Article

References (41)

1. 2 enzymes: Classification and characterization. Biochim. Biophys. Acta 1488:1-19.
2. 2: Mediators of inflammation, proliferation and apoptosis. Prog. Lipid Res. 40:167-197.
3. 2 gene expression in human hepatoma cells by mediators of the acute phase response. J. Biol. Chem. 266:2647-2651.
4. 2 in serum is an acute phase reactant. Res. Commun. Chem. Pathol. Pharmacol. 75:109-115.
5. 2 in inflammatory diseases. Clin. Chem. 39:2453-2459.
6. 2 in human atherosclerotic plaques. Atherosclerosis 118:173-181.
7. 2 by CD1a positive cells in human atherosclerotic plaques. Atherosclerosis 127:283-285.
8. 2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins. Arterioscler. Thromb. Vasc. Biol. 17:300-309.
9. 2 isoforms in human normal and atherosclerotic arterial wall. Arterioscler. Thromb. Vasc. Biol. 17:2257-2263.
10. 2 in atherosclerotic and nonatherosclerotic regions of human arteries. Arterioscler. Thromb. Vasc. Biol. 18:519-525.
11. 2. Atherosclerosis 132:165-176.
12. 2: Preferential hydrolysis of acute phase HDL. J. Lipid Res. 39:2150-2160.
13. 2 alters the expression of selected apoB-100 epitopes and the interaction of LDL with cells. J. Lipid Res. 29:729-743.
14. 2 treatment. Atherosclerosis 117:159-167.
15. 2. A spin label study. Biochim. Biophys. Acta 1300:103-113.
16. 2-treated low density lipoproteins. Biochem. (Moscow) 63:1430-1437.
17. 2 modification of low density lipoproteins forms small high density particles with increased affinity for proteoglycans and glycosaminoglycans. J. Biol. Chem. 274:25913-25920.
18. 2-modified LDL is taken up at enhanced rate by macrophages. Biochim. Biophys. Res. Commun. 185:465-472.
19. 2-modified lipoproteins leads to cellular lipid accumulations. Anal. Cell. Pathol. 9:113-121.
20. Bamberger, M., J. M. Glick, and G. H. Rothblat. 1983. Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells. J. Lipid Res. 24:869-876.
21. Bamberger, M., S. Lund-Katz, M. C. Phillips, and G. H. Rothblat. 1985. Mechanism of the hepatic lipase induced accumulation of high-density lipoprotein cholesterol by cells in culture. Biochemistry 24:3693-3701.
22. Collet, X., B.-P. Perret, G. Simard, C. Vieu, and L. Douste-Blazy. 1990. Behaviour of phospholipase-modified HDL towards cultured hepatocytes. I. Enhanced transfer of HDL sterols and apoproteins. Biochim. Biophys. Acta 1043:301-310.
23. 2: Influence on lipoprotein metabolism. J. Lipid Res. 38:2232-2239.
24. 2 is associated with reduced concentrations of plasma cholesterol in transgenic mice. Inflammation 24:227-237.
25. 2. Arterioscler. Thromb. Vasc. Biol. 19:1284-1290.
26. Labeque, R., C. J. P. Mullon, J. P. M., Ferreira, R. S. Lees, and R. Langer. 1993. Enzymatic modification of plasma low density lipoproteins in rabbits: A potential treatment for hypercholesterolemia. Proc. Natl. Acad. Sci. U.S.A. 90:3476-3480.
27. 2 causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J. Biol. Chem. 275:10077-10084.
28. 2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate. J. Clin. Invest. 97:2233-2241.
29. 2 in transgenic mice. J. Histochem. Cytochem. 45:1109-1119.
30. 2 inhibitors. Eur. J. Pharmacol. 308:195-203.
31. 2 gene in inbred mouse strains. J. Biol. Chem. 270:22378-22385.
32. 2 assay modified for serum analysis. Clin. Chem. 39:605-613.
33. Aufenanger, J., P. Haux, and R. Kattermann. 1989. Improved method for enzymic determination of cholesterol in lipoproteins seperated by electrophoresis on thin layer agarose gels. J. Chem. Clin. Biochem. 27:807-813.
34. Macart, M. and L. Gerbaut. 1982. An improvement of the Coomassie Blue dye binding method allowing an equal sensitivity to various proteins: Application to cerebrospinal fluid. Clin. Chim. Acta 122:93-101.
35. Vercaemst, R., A. Union, M. Rosseneu, I. de Craene, G. de Backer, and M. Kornitzer. 1989. Quantitation of plasma free cholesterol and cholesteryl esters by high performance liquid chromatography. Atherosclerosis 78:245-250.
36. Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and G. Kollias. 1991. Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis. EMBO J. 10:4025-4031.
37. 2 and C-reactive protein in the removal of injured cells. Immunol. Today 18:111-115.
38. Wilson, D. E., G. R. Birchfield, J. S. Hejazi, J. H. Ward, and W. E. Samlowski. 1989. Hypocholesterolemia in patients treated with recombinant interleukin-2: Appearance of remnant-like lipoproteins. J. Clin. Oncol. 7:1573-1577.
39. Grove, R. J., C. Mazzucco, N. Allegretto, P. A. Kiener, G. Spitalny, S. F. Radka, M. Shoyab, M. Antonaccio, and G. A. Warr. 1991. Macrophage-derived factors increase low-density-lipoprotein uptake and receptor number in cultured human liver cells. J. Lipid Res. 32:1889-1897.
40. Ettinger, W. H., L. D. Miller, J. J. Albers, T. K. Smith, and J. S. Parks. 1990. Lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: Cholesterol acyltransferase in cynomolgus monkeys. J. Lipid Res. 31:1099-1108.
41. Ettinger, W. H., V. K. Varma, M. Scorci-Thomas, J. S. Parks, R. C. Sigmon, T. K. Smith, and R. B. Verdery. 1994. Cytokines decrease apolipo protein accumulation in medium from HepG2 cells. Arterioscler. Thromb. 14:8-13.