Lethal synergistic effect of cigarette smoke and saliva in an in vitro model: Does saliva have a role in the development of oral cancer?

European Journal of Cancer

Volumn 40, Issue 11, 2004, Pages 1760-1767

  Hershkovich, Oded ^a,b,c   Oliva, Jorge ^c   Nagler, Rafael M ^a,b  

^a RAMBAM MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Herzlia Haifa Horev Medical Center   (Israel)

Author keywords

Aldehydes; Cigarette smoke; Free radicals; in vitro; Oral cancer; Oxidative stress; Saliva

Indexed keywords

ALDEHYDE DERIVATIVE; CIGARETTE SMOKE; FREE RADICAL; HYDROXYL GROUP; IRON;

ARTICLE; CARCINOGENESIS; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; FENTON REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LETHALITY; MOLECULAR MECHANICS; MOUTH CANCER; OXIDATION REDUCTION REACTION; PAROTID GLAND; PHENOMENOLOGY; PRIORITY JOURNAL; REACTION ANALYSIS; SALIVA ANALYSIS; SALIVATION; SMOKING; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND; SURVIVAL RATE;

ADULT; ANTIOXIDANTS; CELL SURVIVAL; DEFEROXAMINE; FEMALE; FREE RADICALS; GLUTATHIONE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; SALIVA; SMOKE; SMOKING;

EID: 3142640649     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.03.027     Document Type: Article

References (56)

1. Lippman S.M., Hong W.K. Molecular markers of the risk of oral cancer. N. Engl. J. Med. 344(17):2001;1323-1326
2. Collins A., Duthie S., Ross M. Micronutrients and oxidative stress in the aetiology of cancer. Proc. Nutr. Soc. 53(1):1994;67-75
3. MacFarlane G.J., Boyle P., Evstifeeva T.V., Robertson C., Scully C. Rising trends of oral cancer mortality among males worldwide: the return of an old public health problem. Cancer Causes Control. 3:1994;259-265
4. Nagler R.M., Barak M., Ben-Aryeh H., Peled N., Filatov M., Laufer D. Early diagnostic and treatment monitoring role of Cyfra 21-1 and TPS in oral squamous cell carcinoma. Cancer. 35:1999;1018-1025
5. Jordan R.C., Daley T. Oral squamous cell carcinoma: new insight. Can. Dent. Assoc. 63(7):1997;517-518. 521-525
6. Ko Y.C., Huang Y.L., Lee C.H., et al. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J. Oral Pathol. Med. 24:1995;450-453
7. Epstein J.B., Scully C. Assessing the patient at risk for oral squamous cell carcinoma. Spec. Care Dentist. 17(4):1997;120-128
8. McGinnis J.M., Foege W.H. Actual causes of death in the United States. JAMA. 270:1993;2207-2212
9. Bross I.D., Coombes J. Early onset of oral cancer among women who drink and smoke. Oncology. 33:1976;136-139
10. Zheng T., Holfold T., Chen Y., Jiang P., Zhang B., Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case control study. Oral Oncol. 33:1997;82-85
11. Holleb A.I., Fink D.J., Murphy G.P. Textbook of clinical oncology. 1991;The American Cancer Society
12. Sudbø J., Kildal W., Risberg B., Koppang H.S., Danielsen H.E., Reith A. DNA content as a prognostic marker in patients with oral leukoplakia. N. Engl. J. Med. 344(17):2001;1270-1278
13. Knak R., Rutsatz K., Gocke R. Salivary investigations in oral lichen planus. J. Dent. Res. 77:1998;. Abstract # 2783
14. Dayan D., Hirshberg A., Kaplan I., et al. Experimental tongue cancer in desalivated rats. Oral Oncol. 33:1997;105-109
15. Nishioka H., Hishi K., Kyokane K. Human saliva inactivates mutagenicity of carcinogens. Mutat. Res. 85:1981;323-333
16. Nagler R., Klein I., Zarzhevsky N., Drigues Nazi, Reznick A.Z. Characterization of the differentiated antioxidant profile of human saliva. Free Radic. Biol. Med. 32(3):2002;268-277
17. Nagler R., Lischinsky S., Diamond E., Drigues N., Klein I., Reznick A. Effect of cigarette smoke on salivary proteins and enzyme activities. Arch. Biochem. Biophys. 379(2):2000;229-236
18. Nagler R., Lischinsky S., Diamond E., Klein I., Reznick A. New insights into salivary lactate dehydrogenase of human subjects. J. Lab. Clin. Med. 137(5):2001;363-369
19. Nagler R.M., Marmary Y., Fox P.C., Baum B.J., Har-El R., Chevion M. Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper. Radiat. Res. 147:1997;468-475
20. Nagler R.M., Marmary Y., Golan E., Chevion M. Novel protection strategy against irradiation-induced and transition metal-mediated damage to salivary glands. Radiat. Res. 142:1998;271-276
21. Nagler R.M., Marmary Y., Krausz Y., Chisin R., Markitziu A., Nagler A. Salivary gland dysfunction in human acute and chronic graft versus host disease (GVHD). Bone Marrow Transplant. 17:1996;219-224
22. Reznick A.Z., Han D., Packer L. Cigarette smoke induced oxidation of human plasma proteins, lipids and antioxidants, selective protection by the biothiols dihydrolipoic acid and glutathion. Redox Rep. 3:1997;169-174
23. Scheff'e H. The analysis of variance. 1959;Wiley, New York
24. Hockberg Y., Tamhane A.C. Multiple comparison procedures. 1987;Wiley, New York
25. Gosset WS (pseudo Student). On the probable error of a mean. Biometrika 1908, 6, 1-25
26. Carlsson J. Salivary peroxidase: an important part of our defense against oxygen toxicity. J. Ora Pathol. 16:1987;412-416
27. Grisham M.B.;., Ryan E.M. Cytotoxic properties of salivary oxidants. Am. Physiol. 258:1990;C115-C121
28. Stadtman E.R. Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic. Biol. Med. 9(4):1990;315-325
29. Stadtman E.R. Free radical mediated oxidation of proteins. Tomris Ozben Free radicals, oxidative stress and antioxidation. Nato Asi Series. 1998;51-65 Plenum Press, New York
30. Mandel I.D. The role of saliva in maintaining oral homeostasis. JADA. 119:1989;298-304
31. Nagler R.M., Kitrossky N., Chevion M. Antioxidant activity of rat parotid saliva. Arch. Otolarygol. Head Neck Surg. 123:1997;989-993
32. Nair U.J., Floyd R.A., Nair J., et al. Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients. Chem. Biol. Interact. 63:1987;157-169
33. Moore S., Calder K.A., Miller N.J., Rice-Evans C.A. Antioxidant activity of saliva and periodontal disease. Free Radic. Res. 21:1994;417-425
34. Schlotte V., Sevanian A., Hochstein P., Weithmann K.U. Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro. Free Radic. Biol. Med. 25(7):1998;839-847
35. Schulze-Osthoff K., Los M., Baeuerle P.A. Redox signalling by transcription factors NF-KB and AP-1 in lymphocytes. Biochem. Pharm. 50:1995;735-741
36. Gmunder H., Eck H.P., Droge W. Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones. Eur. J. Biochem. 201(1):1991;113-117
37. Ishii T., Sugita Y., Bannai S. Regulation of glutathione levels in mouse spleen by transport of cystein. J. Cell. Physiol. 133(2):1987;330-336
38. Reznick A.Z., Cross C.E., Hu M.L., Suzuki Y.J., Khwaja S., Safadi A., et al. Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem. J. 286(Pt 2):1992;607-611
39. O'Neill C.A., Halliwell B., Van der Vliet A., Davis P.A., Packer I., Tristchler H. Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid. J. Lab. Clin. Med. 124:1994;359-370
40. Schneider M., Diemer K., Engelhart K., Zankl H., Trommer W.E., Biesalski H.K. Protective effects of vitamins C and E on the number of micronuclei in smokers and their role in ascorbate free radical formation in plasma. Free Radic. Res. 34(3):2001;209-219
41. Sopori M.L., Kozak W. Immunomodulatory effects of cigarette smoke. Eur. J. Immunol. 83(1-2):1998;148-156
42. Finette B.A., O'Neill J.P., Vacek P.M., Albertini R.J. Gene mutations with characteristic deletions in cord blood T associated with passive maternal exposure to tobacco smoke. Nat. Med. 4(10):1998;1144-1151
43. Geng Y., Savage S.M., Razani-Boroujerdi S., Sopori M.L. Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. J. Immunol. 156(7):1996;2384-2390
44. Singh S.P., Kalra R., Puttfarcken P., Kozak A., Tesfaigzi J., Sopori M.L. Acute and chronic nicotine exposures modulate the immune system through different pathways. Toxicol. Appl. Pharmacol. 164(1):2000;65-72
45. Yang Q., Hergenhahn M., Weninger A., Bartsch H. Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji. Carcinogenesis. 20(9):1999;1769-1775
46. WHO1992 World Health Organization. Recent advances in oral health. Report of a WHO Expert Committee, Geneva, Switzerland, 1992
47. ′ -deoxyguanosine in DNA in vitro with betel-quid ingredients IARC Sci. Publ. 89:1988;417-421
48. Nguyen H., Finkelstein E., Reznick A., Cross C., van der Vliet A. Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications. Toxicology. 160(1-3):2001;207-217
49. Kaugars G.E., Silverman S. Jr., Lovas J.G., Thompson J.S., Brandt R.B., Singh V.N. Use of antioxidant supplements in the treatment of human oral leukoplakia. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 81(1):1996;5-14
50. Gutteridge J.M. Antioxidants, nutritional supplements and life-threatening diseases. Br. J. Biomed. Sci. 51(3):1994;288-295
51. Trickler D., Shklar G., Schwartz J. Inhibition of oral carcinogenesis by glutathione. Nutr. Cancer. 20(2):1993;139-144
52. Schwartz J.L., West K., Shklar D.P., Shklar G. Altered cytokeratin expression in carcinogenesis inhibition by antioxidant nutrients. Nutr. Cancer. 24(1):1995;47-56
53. Schwartz J.L., Shklar G. Glutathione inhibits experimental oral carcinogenesis, p53 expression, and angiogenesis. Nutr. Cancer. 26(2):1996;229-236
54. Schwartz J.L., Singh R.P., Teicher B., Wright J.E., Trites D.H., Shklar G. Induction of a 70 kD protein associated with the selective cytotoxicity beta-carotene in human epidermal carcinoma. Biochem. Biophys. Res. Commun. 169(3):1990;941-946
55. Gerald Shklar, Joel L. Schwartz Ascorbic acid and cancer. Robin Harris J. Subcellular biochemistry. Ascorbic acid: biochemistry and biomedical cell biology. vol. 25:1996;Plenum Press, New York
56. Schwartz J., Shklar G., Trickler D. Vitamin C enhances the development of carcinomas in the hamster buccal pouch experimental model. Oral Surg. Oral Med. Oral Pathol. 76(6):1993;718-722