Mechanoenergetic inefficiency in the septic left ventricle is due to enhanced oxygen requirements for excitation-contraction coupling

Cardiovascular Research

Volumn 63, Issue 2, 2004, Pages 256-263

  Aghajani, Ebrahim ^a   Nordhaug, Dag ^a   Korvald, Christian ^a   Steensrud, Tor ^a   Husnes, Kjell ^a   Ingebretsen, Ole ^a   Revhaug, Arthur ^a   Myrmel, Truls ^a  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

EC coupling; Endotoxins; Hemodynamics; Oxygen consumption; Septic shock

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN; POTASSIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; ENERGY CONSUMPTION; ESCHERICHIA COLI; EXCITATION CONTRACTION COUPLING; HEART HEMODYNAMICS; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; SWINE;

ANIMALS; CARDIOPULMONARY BYPASS; ELECTROPHYSIOLOGY; HEART ARREST; LIPOPOLYSACCHARIDES; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; OXYGEN CONSUMPTION; SHOCK, SEPTIC; SWINE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 3142608848     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.04.019     Document Type: Article

References (22)

1. Krishnagopalan S., Kumar A., Parrillo J.E., Kumar A. Myocardial dysfunction in the patient with sepsis. Curr. Opin. Crit. Care. 8:2002;376-388
2. Riedemann N.C., Guo R.F., Ward P.A. The enigma of sepsis. J. Clin. Invest. 112:2003;460-467
3. Dhainaut J.F., Huyghebaert M.F., Monsallier J.F., et al. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation. 75:1987;533-541
4. Cunnion R.E., Schaer G.L., Parker M.M., Natanson C., Parrillo J.E. The coronary circulation in human septic shock. Circulation. 73:1986;637-644
5. Aghajani E., Korvald C., Nordhaug D., Sager G., Revhaug A., Myrmel T. E. coli sepsis induces profound mechanoenergetic inefficiency in the porcine left ventricle. Shock. 21:2004;103-109
6. Suga H. Ventricular energetics. Physiol. Rev. 70:1990;247-277
7. Korvald C., Elvenes O.P., Myrmel T. Myocardial substrate metabolism influences left ventricular energetics in vivo. Am. J. Physiol., Heart Circ. Physiol. 278:2000;H1345-H1351
8. Baan J., van der Velde E.T., de Bruin H.G., et al. Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation. 70:1984;812-823
9. Korvald C., Elvenes O.P., Aghajani E., Myhre E.S., Myrmel T. Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism. Am. J. Physiol., Heart Circ. Physiol. 281:2001;H2645-H2653
10. Nielsen J., Ytrebo L.M., Borud O. Lactate and pyruvate concentrations in capillary blood from newborns. Acta Paediatr. 83:1994;920-922
11. Glower D.D., Spratt J.A., Snow N.D., et al. Lof the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work Circulation. 71:1985;994-1009
12. Burkhoff D., Sugiura S., Yue D.T., Sagawa K. Contractility-dependent curvilinearity of end-systolic pressure-volume relations. Am. J. Physiol. 252:1987;H1218-H1227
13. Schipke J.D., Korbmacher B., Schwanke U., Frehen D., Schmidt T., Arnold G. Basal metabolism does not account for high O2 consumption in stunned myocardium. Am. J. Physiol. 274:1998;H743-H746
14. Hotchkiss R.S., Karl I.E. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA. 267:1992;1503-1510
15. 2 cost of contractility in canine stunned heart. Am. J. Physiol., Heart Circ. Physiol. 278:2000;H1464-H1472
16. 2 metabolism in endotoxic pigs: effect of ibuprofen and meclofenamate. J. Appl. Physiol. 67:1989;1950-1957
17. 2 inhibitor on right ventricular-arterial coupling in endotoxic shock. Shock. 21:2004;45-51
18. Herbertson M.J., Werner H.A., Studer W., Russell J.A., Walley K.R. Decreased left ventricular contractility during porcine endotoxemia is not prevented by ibuprofen. Crit. Care Med. 24:1996;815-819
19. Pinsky M.R., Rico P. Cardiac contractility is not depressed in early canine endotoxic shock. Am. J. Respir. Crit. Care Med. 161:2000;1087-1093
20. Constable P.D. Acute endotoxemia increases left ventricular contractility and diastolic stiffness in calves. Shock. 12:1999;391-401
21. Maughan W.L., Sunagawa K., Burkhoff D., Sagawa K. Effect of arterial impedance changes on the end-systolic pressure-volume relation. Circ. Res. 54:1984;595-602
22. Freeman G.L., Little W.C., Orourke R.A. Influence of heart-rate on left-ventricular performance in conscious dogs. Circ. Res. 61:1987;455-464