Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Korvald, Christian ^a   Petter Elvenes, O D D ^a   Aghajani, Ebrahim ^b   Myhre, Eivind S P ^a   Myrmel, Truls ^a  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Contractile efficiency; Energy metabolism; Pig; Stunning; Ventricular function

Indexed keywords

FATTY ACID; GLUCOSE; OLEIC ACID; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY OCCLUSION; ARTICLE; CONTROLLED STUDY; ENERGY TRANSFER; FATTY ACID OXIDATION; GLUCOSE UTILIZATION; HEART CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; MALE; NONHUMAN; PATHOGENESIS; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; STUNNED HEART MUSCLE; SWINE;

EID: 0035662148     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.6.h2645     Document Type: Article

References (40)

1. Continuous measurement of left ventricular volume in animals and humans by conductance catheter
2. Myocardial 'stunning' in man
3. Molecular and cellular mechanisms of myocardial stunning
4. The stunned myocardium: Prolonged, postischemic ventricular dysfunction
5. Acute right ventricular dilatation in response to ischemia significantly impairs left ventricular systolic performance
6. Cellular and mitochondrial energy metabolism in the stunned myocardium
7. Glucose for the heart
8. "Myocardial stunning" remaining questions
9. Relationship between total mechanical energy and oxygen consumption in the stunned myocardium
10. Quantification of regional myocardial dysfunction after acute ischemic injury
11. Linearity of the Frank-Starling relationship in the intact heart: The concept of preload recruitable stroke work
12. Epinephrine-stimulated contractile and metabolic reserve in postischemic rat myocardium
13. Fatty acid metabolism and contractile function in the reperfused myocardium. Multinuclear NMR studies of isolated rabbit hearts
14. Myocardial substrate metabolism influences left ventricular energetics in vivo
15. Oxygen waste of inotropy in the virtual work model
16. Characterization of postischemic myocardial oxygen utilization
17. 2- transients underlie stunning?
18. Increased activity of the sarcoplasmic reticular calcium pump in porcine stunned myocardium
19. Oxygen consumption and coronary reactivity in postischemic myocardium
20. Myocardial stunning: The role of oxidative substrate metabolism
21. Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts
22. Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium
23. O2 during reperfusion of ischemic hearts
24. The relative contribution of glucose and fatty-acids to ATP production in hearts reperfused following ischemia
25. Assessment of diastolic function: Suggested methods and future considerations
26. Increased oxygen cost of contractility in stunned myocardium of dog
27. Fuels: Aerobic and anaerobic metabolism
28. Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia
29. ATP synthesis kinetics and mitochondrial function in the postischemic myocardium as studied by 31P NMR
30. Cardiac efficiency
31. 2 consumption in stunned myocardium
32. Utilization of oxygen by the contractile apparatus is disturbed during reperfusion of postischaemic myocardium
33. Myocardial oxygen consumption, oxygen supply/demand heterogeneity, and microvascular patency in regionally stunned myocardium
34. Left ventricular stroke volume by single and dual excitation of conductance catheter in dogs
35. Ventricular energetics
36. Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs
37. Is tau a preload-independent measure of isovolumetric relaxation?
38. Domestic pigs in the study of myocardial ischemia
39. Influence of free fatty acids on myocardial oxygen consumption and ischemic injury
40. Metabolic correlates of reversibly injured myocardium