The antiplatelet activity of PMC, a potent α-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase

British Journal of Pharmacology

Volumn 127, Issue 5, 1999, Pages 1206-1212

  Sheu, Joen R ^a   Lee, Cheng R ^a   Lin, Chang C ^b   Kan, Ya C ^a   Lin, Chien H ^a   Hung, Wei C ^c   Lee, Yen M ^c   Yen, Mao H ^c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

tocopherol; Cyclo oxygenase; Platelet aggregation; PMC

Indexed keywords

6 HYDROXY 2,2,5,7,8 PENTAMETHYLCHROMAN; ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL DERIVATIVE; ARACHIDONIC ACID; CALCIUM ION; COLLAGEN; IMIDAZOLE; PHOSPHATIDYLINOSITIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; THROMBOXANE A2;

ARTICLE; CALCIUM MOBILIZATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ANTIOXIDANTS; CALCIUM; CHROMANS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PHOSPHATIDYLINOSITOLS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBOXANE B2; THROMBOXANE-A SYNTHASE;

EID: 0032795923     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702637     Document Type: Article

References (25)

1. AGRADI, E., PETRONI, A., SOCINI, A. & GALLI, C. (1981). In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. Prostaglandins, 22, 255-266.
2. BERRIDGE, M.J. (1983). Rapid accumulation of inositol trisphosphate roveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem. J., 212, 249-258.
3. BORN, G.V.R. & CROSS, M.J. (1963). The aggregation of blood platelets. J. Physiol., 168, 178-195.
4. BROEKMAN, M.J., WARD, J.W. & MARCUS, A.J. (1980). Phospholipid metabolism in phosphatidyl inositol, phosphatic acid and lysophospholipids. J. Clin. Invest., 66, 275-283.
5. BURTON, G.W., CHENG. S.C., WEBB, A. & INGOLD, K.U. (1986). Vitamin E in young and old human red blood cells. Biochim. Biophys. Acta, 860, 84-90.
6. CHARO, I.E., FEINMAN, R.D. & DETWILER, T.C. (1976). Inhibition of platelet secretion by an antagonist of intracellular calcium. Biochem. Biophys. Res. Commun., 72, 1462-1467.
7. COX, A.C., RAO, G.H., GERRARD, J.M. & WHITE, J.G. (1980). The influence of vitamin E quinone on platelet structure, function, and biochemistry. Blood, 55, 907-914.
8. FREEDMAN, J.E., FARHAT, J.H. LOSCALZO, J. & KEANEY, J.F. (1996). Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation, 94, 2434-2440.
9. GERRARD, J.M., PETERSON, D.A. & WHITE, J.G. (1981). Calcium mobilization. In Platelets in Biology and Pathology, ed. Gordon, J.L. pp. 406-436. Amsterdam: Elsevier.
10. 2+ induces with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
11. 2 production. Biochem. Pharmacol., 31, 1158-1160.
12. HUANG, T.F., SHEU, J.R. & TENG, C.M. (1991). A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom. Biochem. J., 277, 351-357.
13. KAKISHITA, E., SUEHIRO, A., OURA, Y. & NAGAI, K. (1990). Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood. Thromb. Res., 60, 489-499.
14. KARNIGUIAN, A., LEGRAND, Y.J. & CAEN, J.P. (1982). Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cyclic AMP level. Prostaglandins, 23, 437-457.
15. KILBOURN, R.G. & GRIFFITH, O.W. ( 1992). Overproduction of nitric oxide in cytokine-mediated and septic shock. J. Natl. Cancer Invest., 84, 827-831.
16. MCDONALD, L.J. & MURAD, F. (1996). Nitric oxide and cyclic GMP signaling. Proc. Soc. Exp. Biol. Med., 211, 1-6.
17. NEEDLEMAN, P., RAZ, A., FERRENDELLI, J.A. & MINKES, M. (1977). Application of imidazole as a selective inhibitor of thromboxane synthetase in human platelets. Proc. Natl. Acad. Sci. U.S.A., 74, 1716-1720.
18. 1-adrenoceptor in rat kidney mediates increased inositol phospholipid hydrolysis. Br. J. Pharmacol., 91, 367-376.
19. SHEU, J.R., LIN, C.H., PENG, C.H. & HUANG, T.F. (1996). Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix protein via binding to multiple integrin receptors expressed on human hepatoma cells. Proc. Soc. Exp. Biol. Med., 213, 71-79.
20. SHEU, J.R., TENG, C.M. & HUANG, T.F. (1992). Triflavin, an RGD-containing antiplatelet peptide, binds to GP IIIa of ADP-stimulated platelets. Biochem. Biophys. Res. Commun., 189, 1236-1242.
21. STEINER, M. & ANASTASI, J. (1976). Vitamin E: an inhibitor of the platelet release reaction. J. Clin. Invest., 57, 732-737.
22. STEINER, M. & MOWER, R. (1982). Mechanism of action of vitamin E on platelet function. Ann. N.Y. Acad. Sci., 393, 289-299.
23. SUZUKI, Y.J. & PACKER, L. (1993). Inhibition of NF-kappa B activation by vitamin E derivatives. Biochem. Biophys. Res. Commun., 193, 277-283.
24. VATASSERY, G.T., MORLEY, J.E. & KUSKOWSKI, M.A. (1983). Vitamin E in plasma and platelets of human diabetic patients and control subjects. Am. J. Clin. Neut., 37, 641-644.
25. 2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. Biochem. Biophys. Res. Commun., 120, 579-585.