Resting state conformation of the MsbA homodimer as studied by site-directed spin labeling

Biochemistry

Volumn 43, Issue 26, 2004, Pages 8600-8606

  Buchaklian, Adam H ^a   Funk, Andrea L ^a   Klug, Candice S ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARACTERIZATION; CRYSTAL STRUCTURE; MEMBRANES; PARAMAGNETIC RESONANCE; PROTEINS;

CROSS-LINKING TECHNIQUE; HELICES;

ESCHERICHIA COLI;

LIPID A;

ANALYTIC METHOD; ARTICLE; BACTERIAL CELL; CROSS LINKING; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; GRAM NEGATIVE BACTERIUM; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS; SPIN LABELING; STRUCTURE ANALYSIS;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DIMERIZATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; KINETICS; LIPID METABOLISM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 3142580842     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0497751     Document Type: Article

References (36)

1. Poole, K. (2003) Overcoming multidrug resistance in gram-negative bacteria. [Review]. Curr. Opin. Invest. Drugs 4, 128-139.
2. Leonessa, F., and Clarke, R. (2003) ATP binding cassette transporters and drug resistance in breast cancer. Endocr.-Relat. Cancer 10, 43-73.
3. Nachega, J. B., and Chaisson, R. E. (2003) Tuberculosis drug resistance: a global threat. Clin. Infect. Dis. 36, S24-S30.
4. Thomas, H., and Coley, H. M. (2003) Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10, 159-165.
5. Tsuruo, T., Naito, M., Tomida, A., Fujita, N., Mashima, T., Sakamoto, H., and Haga, N. (2003) Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. [Review]. Cancer Sci. 94, 15-21.
6. Kellen, J. A. (2003) The reversal of multidrug resistance: an update. J. Exp. Ther. Oncol. 3, 5-13.
7. Gottesman, M. M., and Ambudkar, S. V. (2001) Overview: ABC transporters and human disease. [Review]. J. Bioenerg. Biomembr. 33, 453-458.
8. Cotten, J. F., and Welsh, M. J. (1997) Covalent modification of the regulatory domain irreversibly stimulates cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 272, 25617-25622.
9. Chen, C. J., Clark, D., Ueda, K., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1990) Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J. Biol. Chem. 265, 506-514.
10. Dean, M., Hamon, Y., and Chimini, G. (2001) The human ATP-binding cassette (ABC) transporter superfamily. [Review]. J. Lipid Res. 42, 1007-1017.
11. Chang, G., and Roth, C. B. (2001) Structure of MsbA from E. coli: a homologue of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293, 1793-1800.
12. Chang, G. (2003) Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homologue in a closed conformation. J. Mol. Biol. 330, 419-430.
13. Diederichs, K., Diez, J., Greller, G., Muller, C., Breed, J., Schnell, C., Vonrhein, C., Boos, W., and Welte, W. (2000) Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19, 5951-5961.
14. Hung, L. W., Wang, I. X., Nikaido, K., Liu, P. Q., Ames, G. F., and Kim, S. H. (1998) Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396, 703-707.
15. Rosenberg, M. F., Kamis, A. B., Callaghan, R., Higgins, C. F., and Ford, R. C. (2003) Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J. Biol. Chem. 278, 8294-8299.
16. Hopfner, K. P., Karcher, A., Shin, D. S., Craig, L., Arthur, L. M., Carney, J. P., and Tainer, J. A. (2000) Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101, 789-800.
17. Fetsch, E. E., and Davidson, A. L. (2003) Maltose transport through the inner membrane of E. coli. Front. Biosci. 8, D652-D660.
18. Ames, G. F., Nikaido, K., Wang, I. X., Liu, P. Q., Liu, C. E., and Hu, C. (2001) Purification and characterization of the membrane-bound complex of an ABC transporter, the histidine permease. J. Bioenerg. Biomembr. 33, 79-92.
19. Karow, M., and Georgopoulos, C. (1993) The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Mol. Microbiol. 7, 69-79.
20. Zhou, Z., White, K. A., Polissi, A., Georgopoulos, C., and Raetz, C. R. (1998) Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis. J. Biol. Chem. 273, 12466-12475.
21. Karow, M., and Georgopoulos, C. (1993) The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Mol. Microbiol. 7, 69-79.
22. Campbell, J. D., Biggin, P. C., Baaden, M., and Sansom, M. S. P. (2003) Extending the structure of an ABC transporter to atomic resolution: Modeling and simulation studies of MsbA. Biochemistry 42, 3666-3673.
23. Thomas, P. J., and Hunt, J. F. (2001) A snapshot of Nature's favorite pump. Nat. Struct. Biol. 8, 920-923.
24. Higgins, C. F., and Linton, K. J. (2001) Structural biology. The xyz of ABC transporters. Science 293, 1782-1784.
25. Klug, C. S., and Feix, J. B. (2004) SDSL: A survey of biological applications, in Biological Magnetic Resonance Volume 24 (Berliner, L. J., Eaton, S. S., and Eaton, G. R., Eds.) pp 269-308, Kluwer Academic/Plenum Publishers, Hingham, MA.
26. Klug, C. S., Su, W., and Feix, J. B. (1997) Mapping of the residues involved in a proposed beta-strand located in the ferric enterobactin receptor FepA using site-directed spin-labeling. Biochemistry 36, 13027-13033.
27. Hubbell, W. L., Cafiso, D. S., and Altenbacch, C. (2000) Identifying conformational changes with site-directed spin labeling. [Review]. Nat. Struct. Biol. 7, 735-739.
28. Hubbell, W. L., Gross, A., Langen, R., and Lietzow, M. A. (1998) Recent advances in site-directed spin labeling of proteins. [Review]. Curr. Opin. Struct. Biol. 8, 649-656.
29. Isas, J. M., Langen, R., Haigler, H. T., and Hubbell, W. L. (2002) Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry 41, 1464-1473.
30. Doerrler, W. T., and Raetz, C. R. (2002) ATPase activity of the MsbA lipid flippase of Escherichia coli. J. Biol. Chem. 277, 36697-36705.
31. Gonzalez-Romo, P., Sanchez-Nieto, S., and Gavilanes-Ruiz, M. (1992) A modified colorimetric method for the determination of orthophosphate in the presence of high ATP concentrations. Anal. Biochem. 200, 235-238.
32. Altenbach, C., Flitsch, S. L., Khorana, H. G., and Hubbell, W. L. (1989) Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines. Biochemistry 28, 7806-7812.
33. Altenbach, C., Greenhalgh, D. A., Khorana, H. G., and Hubbell, W. L. (1994) A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin. Proc. Natl. Acad. Sci. U.S.A. 91, 1667-1671.
34. Dalton, L. A., McIntyre, J. O., and Flewelling, R. F. (1987) Distance estimate of the active center of d-b-hydroxybutyrate dehydrogenase from the membrane surface. Biochemistry 26, 2117-2130.
35. Zhao, M., Zen, K. C., Hernandez-Borrell, J., Altenbach, C., Hubbell, W. L., and Kaback, H. R. (1999) Nitroxide scanning electron paramagnetic resonance of helices IV and V and the intervening loop in the lactose permease of Escherichia coli. Biochemistry 38, 15970-15977.
36. Sun, J., Voss, J., Hubbell, W. L., and Kaback, H. R. (1999) Proximity between periplasmic loops in the lactose permease of Escherichia coli as determined by site-directed spin labeling. Biochemistry 38, 3100-3105.