Induction of Very Low Density Lipoprotein Receptor (VLDLR) transcription by VLDL is mediated by the extracellular signal-regulated kinase signaling pathway

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 23, Issue 2, 2003, Pages 97-100

  Wang, Yan ^a   Qu, Shen ^a   Zong, Yiqiang ^a   Zhang, Mingtao ^a   Wu, Fan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Signal transduction; VLDL; VLDL receptor

Indexed keywords

SIGNAL TRANSDUCTION; VLDL; VLDL RECEPTOR; WESTERN BLOT ANALYSIS;

ENZYME INHIBITION; ENZYMES; PROTEINS; RNA; SIGNALING;

CELL CULTURE;

CCAAT BINDING FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEAR FACTOR Y; TRANSCRIPTION FACTOR; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL; ARTICLE; CATTLE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; MACROPHAGE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CATTLE; CCAAT-BINDING FACTOR; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; LIPOPROTEINS, VLDL; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; RATS; RECEPTORS, LDL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 3142530370     PISSN: 0257716X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Sadao T, Jinya S, Mitsuyuki K et al. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase. J Biol Chem, 1995, 270(26):15747
2. Hiltunen T P, Luoma J S, Nikkari T et al. Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion development. Circulation, 1998, 97(11):1079
3. Kosaka S, Takahashi S, Masamura K et al. Evidence of macrophage foam cell formation by very low-density lipoprotein receptor; interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages. Circulation, 2001, 103(8):1142
4. Ioanna G B, Heiner K, Hans V et al. Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth. British Journal of Pharmacology, 2001, 132(8):1725
5. Kreuter R, Soutar A K, Wade D P. Transcription factors CCAAT/enhancer-binding protein beta and nuclear factor-Y bind to discrete regulatory elements in the very low density lipoprotein receptor promoter. J Lipid Res, 1999, 40(3):376
6. Wittmaack F M, Gafvel M E et al. Location and Regulation of the human very low density lipoprotein/ apolipoprotein-e receptor: trophoblast expression predicts a role for the receptor in placental lipid transport. Endocrinology, 1995, 136(1):340
7. Lowry O H. Rosehrough N J, Farr A L et al. Protein measurement with the Folin phenol reagent. J Biol Chem, 1951, 193:265
8. Wada Y, Homma Y, Nakazato K et al. Effect of overexpression of very low density lipoprotein receptor on cell growth. Heart Vessels, 2000, 15(2):74
9. Marziali G, Perrotti E, Ilari R et al. The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: regulation of tissuespecific genes through a ubiquitous transcription factor. Blood, 1999, 93(2):519
10. Wood J L, Russo A F. Autoregulation of cell-specific MAP kinase control of the tryptophan hydroxylase promoter. J Biol Chem, 2001, 276(24):21262
11. Hafner S, Adler H S, Mischak H et al. Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol, 1994, 14:6696
12. Grewal S S, Horgan A M, York R D et al. Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. J Biol Chem, 2000, 275:3722
13. Yanhua H, Hermann Dietrich, Bernhard Metzler et al. Hyperexpression and activation of extracellular signal-regulated kinases (ERK1/2) in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler Thromb Vase Biol, 2000, 20:18
14. Kusuhara M, Chait A, Cader A et al. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vase Biol, 1997, 17(1):141
15. Zhao D, Letterman J, Schreiber B M. Beta-Migrating very low density lipoprotein (beta VLDL) activates smooth muscle cell mitogen-activated protein (MAP) kinase via G protein-coupled receptor-mediated transactivation of the epidermal growth factor (EGF) receptor: effect of MAP kinase activation on beta VLDL plus EGF-induced cell proliferation. J Biol Chem, 2001, 276(33):30579
16. Cong L, Fredric B K, Thomas E et al. Induction of low-density lipoprotein receptor (LDLR) transcription by on-costatin M is mediated by the extracellular signal-regulated kinase signaling pathway and the repeat 3 element of the LDLR promoter. J Biol Chem, 1999, 274(10):6747
17. Hsien-Yeh H, Yuh-Ching T. Tumor necrosis factor-α-mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. J Biol Chem, 2000, 275(52):41035