Transcription factors CCAAT/enhancer-binding protein and nuclear factor- Y bind to discrete regulatory elements in the very low density lipoprotein receptor promoter

Journal of Lipid Research

Volumn 40, Issue 3, 1999, Pages 376-386

  Kreuter, Renée ^a   Soutar, Anne K ^a   Wade, David P ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

BeWo placental trophoblast cells; Gene regulation; Huh 7 hepatoma cells; LDL receptor family; Luciferase

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CIS ACTING ELEMENT; DNA FRAGMENT; ISOPROTEIN; LIPOPROTEIN RECEPTOR; NUCLEAR FACTOR; NUCLEAR FACTOR Y; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE LOCATION; HEPATOMA CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REGULATORY MECHANISM; RNA ANALYSIS; SITE DIRECTED MUTAGENESIS; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; TROPHOBLAST;

CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CLONING, MOLECULAR; DEOXYRIBONUCLEASE I; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, LDL; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

EID: 0033046448     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Takahashi, A. S., Y. Kawarabayasi, T. Nakai, J. Sakai, and T. Yamamoto. 1992. Rabbit very low density lipoprotein receptor: a low density receptor-like protein with distinct ligand specificity. Proc. Natl. Acad. Sci. USA. 89: 9252-9256.
2. Argraves, K. M., F. D. Battey, F. D. MacCalman, K. R. McCrae, M. Gafvels, K. F. Kozarsky, D. A. Chappell, J. F. Strauss 3rd, and D. K. Strickland. 1995. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. J. Biol. Chem. 270: 20550-26557.
3. Battey, F. D., M. E. Gafvels, D. J. FitzGerald, W. S. Argraves, D. A. Chappell, J. F. Strauss 3rd, and D. K. Strickland. 1994. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J. Biol. Chem. 269: 23268-23273.
4. Heegaard, C. W., A. C. Simonsen, K. Oka, L. Kjoller, A. Christensen, B. Madsen, L. Ellgaard, L. Chan, and P. A. Andreasen. 1995. Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex. J. Biol. Chem. 270: 20855-20861.
5. r-40,000 receptor-associated protein. Eur. J. Biochem. 248: 583-591.
6. Gafvels, M. E., M. Caird, D. Britt, C. L. Jackson, D. Patterson, and J. F. Strauss 3rd. 1993. Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoproteinE receptor and assignment of the gene to chromosome 9pter-p23. Somat. Cell Mol. Genet. 19: 557-569.
7. Gafvels, M. E., L. G. Paavola, C. O. Boyd, P. M. Nolan, F. Wittmaack, A. Chawla, M. A. Lazar, M. Bucan, B. O. Angelin, and J. F. Strauss 3rd. 1994. Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19. Endocrinology. 135: 387-394.
8. Oka, K., K. Ishimura-Oka, M. J. Chu, M. Sullivan, J. Krushkal, W. H. Li, and L. Chan. 1994. Mouse very-low-density-lipoprotein receptor (VLDLR) tDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. Eur. J. Biochem. 224: 975-982.
9. Webb, J. C., D. D. Patel, M. D. Jones, B. L. Knight, and A. K. Soutar. 1994. Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA. Hum. Mol. Genet. 3: 531-537.
10. Frykman, P. K., M. S. Brown, T. Yamamoto, J. L. Goldstein, and J. Herz. 1995. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA. 92: 8453-8457.
11. Wittmaack, F. M., M. E. Gafvels, M. Bronner, H. Matsuo, K. R. McCrae, J. E. Tomaszewski, S. L. Robinson, D. K. Strickland, and J. F. Strauss 3rd. 1995. Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport. Endocrinology. 136: 340-348.
12. Multhaupt, H. A., M. E. Gafvels, K. Kariko, H. Jin, C. Arenas-Elliot, B. I. Goldman, J. F. Strauss 3rd, B. Angelin, M. J. Warhol, and K. R. McCrae. 1996. Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry. Am. J. Pathol. 148: 1985-1997.
13. Wyne, K. L., K. Pathak, M. C. Seabra, and H. H. Hobbs. 1996. Expression of the VLDL receptor in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 16: 407-415.
14. Nakazato, K., T. Ishibashi, J. Shindo, M. Shiomi, and Y. Maruyama. 1996. Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions. Am. J. Pathol. 149: 1831-1838.
15. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Sieidman, J. A. Smith, and K. Struhl. 1991. Current Protocols in Molecular Biology. John Wiley & Sons, New York, 6.3.3-6.3.6.
16. Wade, D. P., G. E. Lindahl, and R. Lawn. 1994. Apolipoprotein[a] gene transcription is regulated by liver-enriched trans-acting factor hepatocyte nuclear factor 1a. J. Biol. Chem. 269: 19757-19765.
17. Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBPisoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5: 1538-1552.
18. Paulweber, B., A. R. Brooks, B. P. Nagy, and B. Levy-Wilson. 1991. Identification of a negative regulatory region 5′ of the human apolipoprotein B promoter. J. Biol. Chem. 266: 21956-21961.
19. Mantovani, R., X-Y. Li, U. Pessara, R. H. van Huisjduijnen, Ch. Benoist, and D. Mathis. 1994. Dominant negative analogs of NF-YA. J. Biol. Chem. 269: 20340-20346.
20. Friedman, A. D., W. H. Landschutz, and S. L. McKnight. 1989. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3: 1314-1322.
21. Tam, S. P., T. K. Archer, and R. G. Deeley. 1985. Effects of estrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2. J. Biol. Chem. 260: 1670-1975.
22. Sakai, J., A. Hoshino, S. Takahashi, Y. Miura, H. Ishii, H. Suzuki, Y. Kawarabayasi, and T. Yamamoto. 1994. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J. Biol. Chem. 269: 2173-2182.
23. Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65: 499-560.
24. Schug, J., and G. C. Overton. 1997. TESS: Transcription element search software on the WWW. Technical Report CBIL-TR-1997-1001-v0.0, of the Computational Biology and Informatics Laboratory, School of Medicine, University of Pennsylvania.
25. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for Il-6 expression (NF-IL6) is a member of the C/EBP family. EMBO J. 6: 1897-1906.
26. Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science. 246: 911-916.
27. Roesler, W. J., G. R. Vandenbork, and R. W. Hanson. 1988. Cyclic AMP and the inductionof eukaryotic gene transcription. J. Biol. Chem. 263: 9063-9066.
28. Steger, D. J., J. H. Hecht, and P. L. Mellon. 1994. GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland. Mol. Cell. Biol. 14: 5592-5602.
29. Fletcher, C., N. Heintz, and R. G. Roeder. 1987. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell. 51: 773-781.
30. Kadonaga, J. T., K. A. Jones, and R. Tjian. 1986. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends. Biochem. Sci. 11: 20-23.
31. Metzger, S., T. Leff, and J. L. Breslow. 1990. Nuclear factors AF-I and C/EBP bind to the human apoB gene promoter and modulate its transcriptional activity in hepatic cells. J. Biol. Chem. 265: 9978-9983.
32. Marziall, G., E. Perrotti, R. Ilari, U. Testa, E.M. Coccia, and A. Battistini. 1997. Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation. Mol. Cell. Biol. 17: 1387-1395.
33. Thomassin, H., D. Hamel, D. Bernier, M. Guertin, and L. Belanger. 1992. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the α1-fetoprotein gene. Further analysis of C/EBPβ and C/EBPγ. Nucleic Acids Res. 20: 3091-3098.
34. Williams, S. C., C. A. Cantwell, and P. F. Johnson. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5: 1553-1567.
35. Ossipow, V., P. Descombes, and U. Schibler. 1993. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl. Acad. Sci USA. 90: 8219-8223.
36. Kim, I-S., S. Sinha, B. de Crombrugghe, and S. N. Maity. 1996. Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Mol. Cell. Biol. 16: 4003-4013.
37. Wang, N., M. J. Bradley, C. Ou, S. V. Abdelsayed, M. D. Wilde, L. R. Taylor, D. R. Wilson, and G. J. Darlington. 1995. Impaired energy homeostasis in C/EBPα knockout mice. Science. 269: 1108-1112.
38. Yeh, W-C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9: 168-181.
39. MacDougald, O. A., and M. D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64: 345-373.
40. Morin, C. L., I. R. Sclaepfer, and R. H. Eckel. 1995. Tumor necrosis factor-a eliminates binding of NF-Y and an octamer-binding protein to the lipoprotein lipase promoter in 3T3-L1 adipocytes. J. Clin. Invest. 95: 1684-1689.