Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice

Journal of Autoimmunity

Volumn 26, Issue 1, 2006, Pages 32-36

  Mizutori, Yumiko ^a   Saitoh, Ohki ^a   Eguchi, Katsumi ^a   Nagayama, Yuji ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Autoimmunity; Dendritic cell; Graves' hyperthyroidism; Thyrotropin receptor

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; RECEPTOR SUBUNIT; THYROTROPIN RECEPTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL ACTIVITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GRAVES DISEASE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; TH1 CELL; TH2 CELL;

ADENOVIRIDAE; ANIMALS; DENDRITIC CELLS; FEMALE; GENETIC VECTORS; GRAVES DISEASE; HYPERTHYROIDISM; MICE; MICE, INBRED BALB C; PROTEIN SUBUNITS; RECEPTORS, THYROTROPIN; THYROID GLAND;

EID: 31344478836     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.08.008     Document Type: Article

References (16)

1. McLachlan SM, Nagayama Y, Rapoport B. Insight into Graves' hyperthyroidism from animal models. Endocr Rev, in press.
2. Y. Nagayama, M. Kita-Furuyama, T. Ando, K. Nakao, H. Mizuguchi, and T. Hayakawa A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor J Immunol 168 2002 2789 2794
3. M. Kita-Furuyama, Y. Nagayama, P. Pichurin, S.M. McLachlan, B. Rapoport, and K. Eguchi Dendritic cells infected with adenovirus expressing the thyrotropin receptor induce Graves' hyperthyroidism in BALB/c mice Clin Exp Immunol 131 2003 234 240
4. I. Mellman, and R.M. Steinman Dendritic cells: specialized and regulated antigen processing machines Cell 106 2001 255 258
5. B. Rapoport, G.D. Chazenbalk, J.C. Jaume, and S.M. McLachlan The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies Endocr Rev 19 1998 673 716
6. G.D. Chazenbalk, P. Pichurin, C.R. Chen, F. Latrofa, A.P. Johnstone, and S.M. McLachlan Thyroid-stimulating autoantibodies in Graves' disease preferentially recognize the free A-subunit, not the thyrotropin holoreceptor J Clin Invest 110 2002 209 217
7. C.-R. Chen, P. Pichurin, Y. Nagayama, F. Latrofa, B. Rapoport, and S.M. McLachlan The thyrotropin receptor autoantigen in Graves' disease is the culprit as well as the victim J Clin Invest 111 2003 1897 1904
8. C.-R. Chen, P. Pichurin, G.D. Chazenbalk, H. Aliesky, Y. Nagayama, and S.M. McLachlan Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease Endocrinology 145 2004 228 233
9. Y. Nagayama, O. Saitoh, S.M. McLachlan, B. Rapoport, H. Kano, and Y. Kumazawa TSH receptor-adenovirus-induced Graves' disease is attenuated in both interferon-γ and interleukin-4 knockout mice; implications for the Th1/Th2 paradigm Clin Exp Immunol 138 2004 417 422
10. G.D. Chazenbalk, A. Kakinuma, J.C. Jaume, S.M. McLachlan, and B. Rapoport Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells Endocrinology 137 1996 4586 4591
11. C. Reis e Sousa, S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, and R.N. Germain In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas J Exp Med 186 1997 1819 1829
12. E.A. Hirschowitz, J.D. Weaver, G.E. Hidalgo, and D.E. Doherty Murine dendritic cells infected with adenovirus vectors show signs of activation Gene Ther 7 2000 1112 1120
13. P.A. Morel, M. Feili-Hariri, P.T. Coates, and A.W. Thomson Dendritic cells, T cell tolerance and therapy of adverse immune reactions Clin Exp Immunol 133 2003 1 10
14. H.-G. Zhang, D. Liu, Y. Heike, P. Yang, Z. Wang, and X. Wang Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells Nat Biotechnol 16 1998 1045 1049
15. T. Takayama, Y. Nishioka, L. Lu, M.T. Lotze, H. Tahara, and A.W. Thomson Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness Transplantation 66 1998 1567 1574
16. L. Lu, A. Gambotto, W.C. Lee, S. Qian, C.A. Bonham, and P.D. Robbins Adenoviral delivery of CTLA4Ig into myeloid Dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients Gene Ther 6 1999 554 563