Expression pattern of the lymphatic and vascular markers VEGFR-3 and CD31 does not predict regional lymph node metastasis in cutaneous melanoma

Archives of Dermatological Research

Volumn 297, Issue 8, 2006, Pages 352-357

  Wobser, Marion ^a   Siedel, Claudia ^a   Schrama, David ^a   Bröcker, Eva B ^a   Becker, Juergen C ^a   Vetter Kauczok, Claudia S ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

CD31; Lymphangiogenesis; Malignant melanoma; Sentinel lymph node biopsy; VEGFR 3

Indexed keywords

CD31 ANTIGEN; VASCULOTROPIN RECEPTOR 3;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MALE; MELANOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SENTINEL LYMPH NODE;

AGED; ANTIGENS, CD31; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MELANOMA; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK FACTORS; SENTINEL LYMPH NODE BIOPSY; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 31344470967     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-005-0633-1     Document Type: Article

References (32)

1. Achen MG, Jeltsch M, Kukk E et al (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) Proc Natl Acad Sci USA 20;95:548-553
2. Achen MG, Williams RA, Minekus MP et al (2001) Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis J Pathol 193:147-154
3. Carlson JA, Ross JS, Slominski A et al (2005) Molecular diagnostics in melanoma J Am Acad Dermatol 52:743-775
4. Chang LK, Garcia-Cardena G, Farnebo F et al (2004) Dose-dependent response of FGF-2 for lymphangiogenesis Proc Natl Acad Sci U S A 101:11658-11663
5. Clarijs R, Schalkwijk L, Hofmann UB et al (2002) Induction of vascular endothelial growth factor receptor-3 expression on tumor microvasculature as a new progression marker in human cutaneous melanoma Cancer Res 62:7059-7065
6. Dadras SS, Paul T, Bertoncini J et al (2003) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival Am J Pathol 162:1951-1960
7. de Waal RM, van Altena MC, Erhard H et al (1997) Lack of lymphangiogenesis in human primary cutaneous melanoma. Consequences for the mechanism of lymphatic dissemination Am J Pathol 150:1951-1957
8. He Y, Kozaki K, Karpanen T et al (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling J Natl Cancer Inst 94:819-825
9. He Y, Rajantie I, Pajusola K et al (2005) Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels Cancer Res 65:4739-4746
10. Joukov V, Pajusola K, Kaipainen A et al (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases EMBO J 15:290-298
11. Kajiya K, Hirakawa S, Ma B et al (2005) Hepatocyte growth factor promotes lymphatic vessel formation and function EMBO J 24:2885-2895
12. Kesmodel SB, Karakousis GC, Botbyl JD et al (2005) Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas Ann Surg Oncol 12:449-458
13. Longatto FA, Martins A, Costa SM et al (2005) VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels Pathol Res Pract 201:93-99
14. Makinen T, Jussila L, Veikkola T et al (2001) Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 Nat Med 7:199-205
15. Mandriota SJ, Jussila L, Jeltsch M et al (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis EMBO J 20:672-682
16. Manley PW, Bold G, Bruggen J et al (2004) Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis Biochim Biophys Acta 1697:17-27
17. Padera TP, Kadambi A, di Tomaso E et al (2002) Lymphatic metastasis in the absence of functional intratumor lymphatics Science 296:1883-1886
18. Paget S (1989) The distribution of secondary growths in cancer of the breast 1889. Cancer Metastasis Rev 8:98-101
19. Papoutsi M, Siemeister G, Weindel K et al (2000) Active interaction of human A375 melanoma cells with the lymphatics in vivo Histochem Cell Biol 114:373-385
20. Partanen TA, Alitalo K, Miettinen M (1999) Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors Cancer 86:2406-2412
21. Salven P, Lymboussaki A, Heikkila P et al (1998) Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors Am J Pathol 153:103-108
22. Schmid-Wendtner MH, Baumert J, Eberle J et al (2003) Disease progression in patients with thin cutaneous melanomas (tumour thickness < or = 0.75 mm): clinical and epidemiological data from the Tumour Center Munich 1977-98 Br J Dermatol 149:788-793
23. Schoppmann SF, Birner P, Stockl J et al (2002) Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis Am J Pathol 161:947-956
24. Shields JD, Borsetti M, Rigby H et al (2004) Lymphatic density and metastatic spread in human malignant melanoma Br J Cancer 90:693-700
25. Skobe M, Hawighorst T, Jackson DG et al (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis Nat Med 7:192-198
26. Stacker SA, Caesar C, Baldwin ME et al (2001) EGF-D promotes the metastatic spread of tumor cells via the lymphatics Nat Med 7:186-191
27. Stadelmann WK, Reintgen DS (1998) Prognosis in malignant melanoma Hematol Oncol Clin North Am 12:767-796
28. Torabian S, Kashani-Sabet M (2005) Biomarkers for melanoma Curr Opin Oncol 17:167-171
29. Valtola R, Salven P, Heikkila P et al (1999) VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer Am J Pathol 154:1381-1390
30. White RR, Stanley WE, Johnson JL et al (2002) Long-term survival in 2,505 patients with melanoma with regional lymph node metastasis Ann Surg 235:879-887
31. Wiley HE, Gonzalez EB, Maki W et al (2001) Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma J Natl Cancer Inst 93:1638-1643
32. Zeng Y, Opeskin K, Baldwin ME et al (2004) Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer Clin Cancer Res 10:5137-5144