Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats

Critical Care Medicine

Volumn 34, Issue 2, 2006, Pages 453-460

  Yu, Huang Ping ^a   Lui, Ping Wing ^a   Hwang, Tsann Long ^a   Yen, Chia Hung ^b   Lau, Ying Tung ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NONE

Author keywords

Antioxidant; Cecal ligation and puncture; Endothelial dysfunction; Nitric oxide; Propofol; Reactive oxygen species

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; INTRALIPID; LUCIGENIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRIC OXIDE; OXYGEN; PROPOFOL; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD LEVEL; CAROTID ARTERY; CECUM; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG INFUSION; ENDOTHELIAL DYSFUNCTION; LIGATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; STATISTICAL SIGNIFICANCE; VASCULAR ENDOTHELIUM;

EID: 31344468264     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000198530.68343.21     Document Type: Article

References (56)

1. Parrillo JE: Pathogenetic mechanisms of septic shock. N Engl J Med 1993; 328:1471-1477
2. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329:2002-2012
3. Vallance P, Moncada S: Role of endogenous nitric oxide in septic shock. New Horiz 1993; 1:77-86
4. Astiz ME, Rackow EC: Septic shock. Lancet 1998; 351:1501-1505
5. Gerdin B, Haglund U: Possible involvement of oxygen free radicals in shock and shock-related states. In: Handbook of Mediators in Septic Shock. Neugebauer EA, Holadey JW (Eds). Boca Raton, CRC Press, 1993, pp 457-473
6. Gryglewski RJ, Palmer RMJ, Moncada S: Superoxide anion is involved in the breakdown of endothelium-derived vascular releasing factor. Nature 1986; 320:454-456
7. Brandes RP, Koddenberg G, Gwinner W, et al: Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia. Hypertension 1999; 33:1243-1249
8. Jaeschke H, Smith CW: Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 1997; 61:647-653
9. Latha B, Babu M: The involvement of free radicals in burn injury: a review. Burns 2001; 27:309-317
10. Maxwell AJ: Mechanism of dysfunction of the nitric oxide pathway in vascular diseases. Nitric Oxide 2002; 6:101-124
11. Gewaltig MT, Kojda G: Vasoprotection by nitric oxide: Mechanisms and therapeutic potential. Cardiovasc Res 2002; 55:250-260
12. Deora AA, Lander HM: Regulation of gene expression by nitric oxide. Contemp Cardiol 2000; 4:51-67
13. Colasanti M, Suzuki H: The dual personality of NO. Trends Pharmacol Sci 2000; 21:249-252
14. Pagano PJ, Ito Y, Tornheim K, et al: An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol 1995; 268:H2274-H2280
15. Griendling KK, Sorescu D, Ushio-Fukai M: NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res 2000; 86:494-501
16. Bokoch GM, Knaus UG: NADPH oxidases: Not just for leukocytes anymore! Trends Biochem Sci 2003; 28:502-508
17. Jones SA, O'Donnell VB, Wood JD, et al: Expression of phagocyte NADPH oxidase components in human endothelial cells. Am J Physiol 1996; 271:H1626-H2634
18. Griendling KK, Minieri CA, Ollerenshaw JD, et al: Angiotensin II stimulates NADH and NADPH oxidase activity in cultures vascular smooth muscle cells. Circ Res 1994; 74:1141-1148
19. Meier B, Cross AR, Hancock JT, et al: Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. J Biochem 1991; 275:241-245
20. Jones SA, Hancock JT, Jones OTG, et al: The expression of NADPH oxidase components in human glomerular mesangial cells: Detection of protein and mRNA for p47phox, p67phox, and p22phox. J Am Soc Nephrol 1995; 5:1483-1491
21. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock: A review of laboratory models and a proposal. J Surg Res 1980; 29:189-201
22. McLeod G, Wallis C, Dick J, et al: Use of 2% propofol to produce diurnal sedation in critically ill patients. Intensive Care Med 1997; 23:428-434
23. Green TR, Bennett SR, Nelson VM: Specificity and properties of propofol as an antioxidant free radical scavenger. Toxicol Appl Pharmacol 1994; 129:163-169
24. D'Donnell NG, Baird S, D'Donnell A, et al: Effect of propofol and thiopentone on inducible nitric oxide production. Br J Anaesth 1994; 4:492
25. Mikawa K, Nishina K, Kodama S, et al: Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters. Anesthesiology 2001; 94:652-660
26. Yen CH, Lau YT: Vascular responses in male and female hypertensive rats with hyperhomocysteinemia. Hypertension 2002; 40:322-328
27. West NEJ, Guzik TJ, Black E, et al: Enhanced superoxide production in experimental venous bypass graft intimai hyperplasia: role of NAD(P)H oxidase. Arterioscler Thromb Vasc Biol 2001; 21:189-194
28. Guzik TJ, West NEJ, Black E, et al: Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors. Circ Res 2000; 86:e85-e90
29. Berry C, Hamilton CA, Brosnan MJ, et al: Investigation into the sources of superoxide in human blood vessels. Circulation 2000; 101:2206-2212
30. Florian M, Magder S: Effect of estrogen on superoxide production in oophorectomized rats. Arterioscler Thromb Vasc Biol Conf 2002; 3:105
31. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities or protein utilizing the principal of protein-dye binding. Anal Biochem 1976; 72:248-254
32. Hwang TL, Lau YT, Chen MF, et al: Biphasic intracellular redistribution of a1-adrenergic receptors in rat liver during sepsis. Am J Physiol 1993; 265:R385-R391
33. Yelich MR: Glucoregulatory, hormonal, and metabolic responses to endotoxicosis or cecal ligation and puncture sepsis in the rat: A direct comparison. Circulatory Shock 1990; 31:351-363
34. Hwang TL, Yang JT, Lau YT: Arginine-nitric oxide pathway in plasma membrane of rat hepatocytes during early and late sepsis. Crit Care Med 1999; 27:137-141
35. Curtis S, Cain S: Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin treated dogs. Am Rev Respir Dis 1992; 145:348-354
36. Gammaitoni C, Nasraway S: Normal lactate/pyruvate ratio during over-whelming polymicrobial bacteremia and multiple organ failure. Anesthesiology 1993; 79:213-216
37. Hayes MA, Timmins AC, Yau EHS, et al: Oxygen transport patterns in patients with sepsis syndrome or septic shock: Influence of treatment and relationship to outcome. Crit Care Med 1997; 25:926-936
38. Brookes ZL, Brown NJ, Reilly CS: Effects of hemorrhage on the rat cremaster muscle microcirculation in vivo during intravenous anesthesia. Shock 2002; 18(6):542-548
39. Kondo U, Nakayama M, Murray PA: Effects of propofol anesthesia on pulmonary vascular response to sympathetic a and B adrenoreceptor activation in chronically-instrumented dogs. Anesthesiology 1998; 89:1369
40. Ogawa K, Tanaka S, Murray PA: Propofol potentiates phenylephrine-induced contraction via cyclooxygenase inhibition in pulmonary artery smooth muscle. Anesthesiology 2001; 94:833-839
41. Chaudry IH: Lessons learned in the last century and future directions. Arch Surg 1999; 134:922-929
42. Grimble RF: Interaction between nutrients, pro-inflammatory cytokines and inflammation. Clin Sci 1996; 91:121-130
43. Scott JA, Mehta S, Duggan M, et al: Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis. Am J Respir Crit Care Med 2002; 165:1426-1432
44. Taylor DE, Chio AJ, Piantadosi CA: Reactive oxygen species produced by liver mitochondria of rats in sepsis. Arch Biochem Biophys 1995; 316:70-76
45. Javesghani D, Hussain S, Scheidel J, et al: Superoxide production in the vasculature of lipopolysaccharide-treated rats and pigs. Shock 2003; 19:486-493
46. Aitkenhead AR, Pepperman ML, Willatts SM: Comparison of propofol and midazolam for sedation in critically ill patients. Lancet 1989; 2:704-709
47. Carrasco G, Molina R, Costa J: Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients: A cost-benefit analysis. Chest 1993; 103:557-564
48. Helmy SAK, Wahby MAM, El-Nawaway M: The effect of anesthesia and surgery on plasma cytokine production. Anesthesia 1999; 41:797-798
49. Paterson AA, Heys SD, Hunter J: Propofol and immunomodulation: An in-vitro study. Shock 2004; 7(Suppl):167
50. Taniguchi T, Yamamoto K, Ohmoto N: Effects of propofol on hemodynamic and inflammatory response to endotoxemia in rats. Crit Care Med 2000; 28:1101-1106
51. Taniguchi T, Kanakura H, Yamamoto K: Effects of posttreatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats. Crit Care Med 2002; 30:904-907
52. Weiss M, Buhl R, Medve M: Tumor necrosis factor-alpha modulates the selective interference of hypnotics and sedatives to suppress N-formyl-methionyl-leucyl-phenylalanine-induced oxidative burst formation in neutrophils. Crit Care Med 1998; 25:128-134
53. Kahraman S, Demiryurek AT: Propofol is a peroxynitrite scavenger. Anesth Analg 1997; 84:1127-1129
54. Gao J, Zeng BX, Zhou LJ, Yuan SY: Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats. Br J Anaesth 2004; 92(2):277-279
55. Cheng YJ, Wang YP, Chien CT, et al: Small-dose propofol sedation attenuates the formation of reactive oxygen species in tourniquet-induced ischemia-reperfusion injury under spinal anesthesia. Anesth Analg 2002; 94:1617-1620
56. Marik PE, Zaloga GP: Therapeutic sedation: Has its time come? Crit Care Med 2002; 30(4):949-952