Milk-derived lactoferrin may block tolerance to morphine analgesia

Brain Research

Volumn 1068, Issue 1, 2006, Pages 102-108

  Tsuchiya, Tomohito ^a   Takeuchi, Takashi ^a   Hayashida, Ken Ichiro ^a   Shimizu, Hirohiko ^b   Ando, Kunio ^b   Harada, Etsumori ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b NRL Pharma Inc   (Japan)

Author keywords

Analgesia; Lactoferrin; Morphine tolerance

Indexed keywords

7 NITROINDAZOLE; GUANYLATE CYCLASE INHIBITOR; LACTOFERRIN; METHYLENE BLUE; MORPHINE; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG TOLERANCE; MALE; MILK; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENZYME INHIBITORS; GUANYLATE CYCLASE; INDAZOLES; INFUSIONS, PARENTERAL; LACTOFERRIN; MALE; METHYLENE BLUE; MICE; MICE, INBRED ICR; MILK; MORPHINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE I; PAIN MEASUREMENT; REACTION TIME; RECEPTORS, OPIOID, MU;

ANIMALIA; BOVINAE;

EID: 31344446682     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.11.002     Document Type: Article

References (35)

1. J.H. Brock The physiology of lactoferrin Biochem. Cell. Biol. 80 2002 1 6
2. I.D.G. Duarte, and S.H. Ferreira The molecular mechanism of central analgesia induced by morphine or carbachol and the l-arginine-nitric oxide-cGMP pathway Eur. J. Pharmacol. 221 1992 171 174
3. I.D.G. Duarte, B.B. Lorenzetti, and S.H. Ferreira Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway Eur. J. Pharmacol. 186 1990 289 293
4. C. Fillebeen, M.M. Ruchoux, V. Mitchell, S. Vincent, M. Benaissa, and A. Pierce Lactofferin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4phenylpyridinium treatment Brain Res. Mol. 96 2001 103 113
5. E. Harada, A. Sugiyama, T. Takeuchi, K. Sitizyo, B. Syuto, T. Yajima, and T. Kuwata Characteristic transfer of colostral components into cerebrospinal fluid via serum in neonatal pigs Biol. Neonate 76 1999 33 43
6. E. Harada, Y. Itoh, K. Sitizyo, T. Takeuchi, Y. Araki, and H. Kitagawa Characteristic transport of lactoferrin from the intestinal lumen into the bile via the blood in piglets Comp. Biochem. Physiol. 124A 1999 321 327
7. E. Harada, Y. Araki, E. Furumura, T. Takeuchi, K. Sitizyo, T. Yajima, and T. Kuwata Characteristic transfer of colostrum derived biologically active substances into cerebrospinal fluid via blood in natural suckling neonatal pigs J. Vet. Med., A 49 2002 358 364
8. K. Hayashida, T. Takeuchi, H. Shimizu, K. Ando, and E. Harada Novel central function of milk-derived lactoferrin on anti-nociception mediated by the μ-opioid receptor Brain Res. 965 2003 239 245
9. K. Hayashida, T. Takeuchi, H. Shimizu, K. Ando, and E. Harada Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord Am. J. Physiol. 285 2003 R306 R312
10. K. Hayashida, T. Takeuchi, and E. Harada Lactoferrin enhances peripheral opioid-mediated antinociception via nitric oxide in rats Eur. J. Pharmacol. 484 2004 175 181
11. K. Hayashida, T. Kaneko, T. Takeuchi, H. Shimizu, K. Ando, and E. Harada Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis J. Vet. Med. Sci. 66 2004 149 154
12. N. Kamemori, T. Takeuchi, K. Hayashida, and E. Harada Suppressive effects of milk-derived lactoferrin on the psychological stress in adult rats Brain Res. 1029 2004 34 40
13. A. Kawabata, Y. Fukuzumi, Y. Fukushima, and H. Takagi Antinociceptive effect of l-arginine on the carrageenin-induced hyperalgesia of the rat: possible involvement of central opioidergic systems Eur. J. Phamacol. 218 1992 153 158
14. A. Kawabata, S. Manabe, Y. Manabe, and H. Takagi Effect of topical administration of l-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation Br. J. Pharmacol. 112 1994 547 550
15. H. Kitagawa, Y. Yoshizawa, T. Yokoyama, T. Takeuchi, M.J.R. Talukder, H. Shimizu, K. Ando, and E. Harada Persorption of bovine lactoferrin from the intestinal lumen into the systemic circulation via the portal vein and the mesenteric lymphatics in growing pigs J. Vet. Med. Sci. 65 2003 567 572
16. Y.A. Kolesnikov, Y.X. Pan, A.M. Babey, S. Jain, R. Wilson, and G.W. Pasternak Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: evidence for opposing NO actions on morphine analgesia and tolerance Proc. Natl. Acad. Sci. U. S. A. 94 1997 8220 8225
17. N.B. Lawand, W.D. Willis, and K.N. Westlund Blockade of joint inflammation and secondary hyperalgesia by l-NAME, a nitric oxide synthase inhibitor NeuroReport 8 1997 895 899
18. P.F. Levay, and M. Viljoen Lactoferrin: a general review Haematologica 80 1995 252 267
19. H. Machelska, D. Labuz, R. Przewlocki, and B. Przewlocka Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord J. Pharmacol. Exp. Ther. 282 1997 977 984
20. F.A. Maffei, R.P. Heine, M.J. Whalen, L.F. Mortimer, and J.A. Carcillo Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis Pediatrics 103 1999 987 992
21. P.L. Masson, and J.F. Heremans An iron-binding protein common to many external secretions Clin. Chim. Acta 14 1966 735 739
22. A.B. Mlmberg, and T.L. Yksh Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats Pain 54 1993 291 300
23. P.K. Moore, R.C. Babbedge, P. Wallance, Z.A. Gaffen, and S.L. Hart 7-Nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure Br. J. Pharmacol. 108 1993 296 297
24. P.K. Moore, P. Wallace, Z. Gaffen, S.L. Hart, and R.C. Babbedge Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects Br. J. Phamacol. 103 1993 219 224
25. J.A. Owen, R.A. Tasker, and K. Nakatsu A simple, less stressful rat strainer Experientia 40 1984 306 308
26. C. Sakurada, A. Sugiyama, M. Nakayama, A. Yonezawa, S. Sakurada, and K. Tan-No Antinociceptive effect of spinally injected l-NAME on the acute nociceptive response induced by low concentration of formalin Neurochem. Int. 38 2001 417 423
27. R.D. Sewell, and P.S. Spencer Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats Neuropharmacology 15 1976 683 688
28. A.M. Sousa, and W.A. Prado The dual effect of a nitric oxide donor in nociception Brain Res. 897 2001 9 19
29. T. Takeuchi, K. Hayashida, H. Inagaki, M. Kuwahara, H. Tsubone, and E. Harada Opioid mediated suppressive effect of milk-derived lactoferrin on distress induced by maternal separation in the rat pups Brain Res. 979 2003 216 224
30. T. Takeuchi, H. Kitagawa, and E. Harada Evidence of lactoferrin transportation into blood circulation from intestine via lymphatic pathway in adult rats Exp. Physiol. 89 2004 263 270
31. M.J.R. Talukder, T. Takeuchi, and E. Harada Characteristic transport of colostral macromolecules into the cerebrospinal fluid via plasma in newborn calves J. Dairy Sci. 85 2002 514 524
32. M.J.R. Talukder, T. Takeuchi, and E. Harada Characteristics of lactoferrin receptor in bovine intestine: higher binding activity in Peyer's patches J. Vet. Med., A 50 2003 123 131
33. M.J.R. Talukder, T. Takeuchi, and E. Harada Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves J. Vet. Med. Sci. 65 2003 957 964
34. H. Teschemacher Lactoferrin elicits opioid-mediated antinociception without development of tolerance: central nNOS-1 set off duty? Am. J. Physiol. 285 2003 R302 R305
35. H. Yamaguchi, and T.A. Naito Antinociceptive synergistic interaction between morphine and N omega-nitro l-arginine methyl ester on thermal nociceptive tests in the rats. Can. J. Anaesth. 43 1996 975 981