Dexamethason: By safe means, by fair means

High Altitude Medicine and Biology

Volumn 6, Issue 4, 2005, Pages 273-275

  Schoene, Robert B ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CHEMOKINE RECEPTOR; DEXAMETHASONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN; OXYGEN; PREDNISONE; TADALAFIL;

ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN MICROCIRCULATION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; EDITORIAL; EUPHORIA; HUMAN; LUNG ARTERY PRESSURE; LUNG EDEMA; MOUNTAINEERING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SIDE EFFECT; BREATHING; DRUG EFFECT; LUNG;

ALTITUDE SICKNESS; DEXAMETHASONE; HUMANS; LUNG; RESPIRATION;

EID: 31344432118     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2005.6.273     Document Type: Editorial

References (17)

1. Barquin N., Ciccolella D.E., Ridge K.M., and Sznajder J.I. (1997). Dexamethazone helps regulate the Na-K-ATPase in rat alveolar epithelial cells. Am. J. Physiol. 273:L825-830.
2. Dorschner L., Debruner J., Fischler M., Clarenbach C.F., Christ A., Bloch K.E., Mairbaurl H., and Maggiorini M. (2004). Dexamethazone inhibits sympathetic activity in HAPE-susceptible mountaineers at 4559M. High Alt. Med. Biol. 4:482 (abstract).
3. Felszeghy K., Banisadr G., Rostene W., Nyakas C., and Haour F. (2004.) Dexamethazone down regulates chemokine receptor. CXCR-4 and exerts neuroprotection in hypoxia/ischemia-induced brain injury in neonatal rats. Neuxo Immunomodulation 11:404-413.
4. Fischler M., Dorschner L., Debruner J., Brunner-LaRocca H.-P., Kiencke S., Bernheim A., Mairbaurl H., and Maggiorini M. (2004). Effects of the phosphodiesterase-5 inhibitor tadalafil and dexamethazone on pulmonary arterial pressure during exercise at 4559M in HAPE-susceptible subjects. High Alt. Med. Biol. 5:484 (abstract).
5. Hackett P.H., Roach R.C., Wood R.A., Foutch R.G., Meehan R.T., Rennie D., and Mills W.J., Jr. (1988). Dexamethazone for prevention and treatment of acute mountain sickness. Aviat. Space Environ. Med. 59:950-954.
6. Jobe J.B., Schukitt-Hale B., Banderet L.E., and Rock P.B. (1991). Effects of dexamethazone in high terrestrial altitude on cognitive performance and affect. Aviat. Space Environ. Med. 62:727-732.
7. Johnson T.S., Rocco C., Fulco C.S., Trad L.A., Spark R.F., and Maher J.T. (1984). Prevention of acute mountain sickness by dexamethazone. N. Engl. J. Med. 310:683-686.
8. Keller H.R., Maggiorini M., Bartsch P., and Oelz O. (1995). Simulated descent versus dexamethazone in treatment of acute mountain sickness: A randomized trial. BMJ 310:1232-1235.
9. Krakauer, J. (1997). Into Thin Air. Random House, New York; pp. 204-205.
10. Krasney J.A. (1994). Neurogenic bases for acute altitude illness. Med. Sci. Sports Exerc. 26:195-208.
11. Lafleur J., Jiron M., Demarco M., Kennedy R., Be Lue R., and Shields C. (2003). Cognitive effects of dexamethazone at high altitude. Wilderness Environ. Med. 14: 20-23.
12. Levine B.D., Yoshimura K., Kobayashi T., Fukushima M., Shibamoto T., and Ueda G. (1989). Dexamethazone and the treatment of acute mountain sickness. N. Engl. J. Med. 321:1707-1713.
13. Murata T., Hori M., Sakamoto K., Karaki H., and Ozaki H. (2004). Dexamethazone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries. Am. J. Respir. Crit. Care Med. 170:647-645.
14. Noda M., Suzuki S., Tsubochi H., Sugita M., Mieda S., Kobiashi S., Kubo H., and Kondo T. (2003). Single dexamethazone injection increases alveolar fluid clearance in adult rats. Crit. Care Med. 31:1183-1189.
15. Ogawa F., Koga S., Kuwabara K., Brett J., Maurrow B., Morris S.A., Bilezikian J.P., Silverstein S.C., and Stern D. (1992). Hypoxia-induced increased permeability of endothelial monolayers that occurs through lowering of cellular CAMP levels. Am. J. Physiol. 262:C546-554.
16. Rock P.B., Johnson T.S., Cymerman A., Burse R.L., Falk L.J., and Fulco C.S. (1987). The effect of dexamethazone on symptoms of acute mountain sickness at Pikes Peak, Colorado (4300M). Aviat. Space Environ. Med. 58: 668-672.
17. Stelzner T.J., O'Brien R.F., Sato K., and Weil, J.V. (1988). Hypoxia-induced increases in pulmonary transvascular protein escape in rats: modulation by glucocorticoids. J. Clin. Invest. 82:1840-1847.