Inhibition of Chlamydia pneumoniae replication in HEp-2 cells by interferon-γ: Role of tryptophan catabolism

Journal of Infectious Diseases

Volumn 177, Issue 5, 1998, Pages 1326-1331

  Mehta, Sheetal J ^a   Miller, Richard D ^a   Ramirez, Julio A ^a   Summersgill, James T ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; TRYPTOPHAN;

ARTICLE; BACTERIUM ISOLATION; CELL DIVISION; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DOSE RESPONSE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; INHIBITION KINETICS; ISOLATION PROCEDURE; PRIORITY JOURNAL;

EID: 0031896642     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515287     Document Type: Article

References (17)

1. Grayston JT. Infections caused by Chlamydia pneumoniae strain TWAR. Clin Infect Dis 1992;15:757-63.
2. Grayston JT, Aldous M, Easton BA, et al. Evidence that Chlamydia pneumoniae causes pneumonia and bronchitis. J Infect Dis 1993;168:1231-5.
3. Kuo CC, Gown AM, Benditt EP, Grayston JT. Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain. Arterioscler Thromb 1993;13:1501-4.
4. Hahn DL, Dodge RW, Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis and adult-onset asthma. JAMA 1991;266:225-30.
5. Puolakkainen M, Campbell LA, Kuo CC, Leinonen M, Gronhagan-Riska C, Saikku P. Serological response to Chlamydia pneumoniae in patients with sarcoidosis. J Infect 1996;33:199-205.
6. Shor A, Kuo CC, Patton DL. Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J 1992;82:158-61.
7. Kuo CC, Shor A, Campbell LA, Fukushi H, Patton DL, Grayston JT. Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis 1993;167:841-9.
8. Muhlestein JB, Hammond Eh, Carlquist JF, et al. Increased incidence of Chlamydia species within the coronary arteries of patients with symptomatic atherosclerosis versus other forms of cardiovascular disease. J Am Coll Cardiol 1996;27:1555-61.
9. Ramirez JA, Ahkee S, Summersgill JT, et al. Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. Ann Intern Med 1996;125:979-82.
10. Jackson LA, Campbell LA, Kuo CC, Rodriquez DI, Lee A, Grayston JT. Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen. J Infect Dis 1997;176:292-5.
11. Hammerschlag MR, Chirgwin K, Roblin PM, et al. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin Infect Dis 1992;14:178-82.
12. Falck G, Gnarpe J, Gnarpe H. Persistent Chlamydia pneumoniae infection in a Swedish family. Scand J Infect Dis 1996;28:271-3.
13. Miyashita N, Matsumoto A, Kubota Y, Nadajima M, Niki Y, Matsushima T. Continuous isolation and characterization of Chlamydia pneumoniae from a patient with diffuse panbronchiolitis. Microbiol Immunol 1996;40:547-52.
14. Beauy WL, Belanger TL, Desai AA, Morrison RP, Byrne GI. Tryptophan depletion as a mechanism of γ-interferon mediated chlamydial persistence. Infect Immun 1994;62:3705-11.
15. Beatty WL, Morrison RP, Byrne GI. Reactivation of persistent Chlamydia trachomatis infection in cell culture. Infect Immun 1995;63:199-205.
16. Summersgill JT, Sahney NN, Gaydos CA, Quinn TC, Ramirez JA. Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with γ-interferon and tumor necrosis factor-α. Infect Immun 1995;63:2801-3.
17. Pfefferkorn ER. Interferon-γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cell to degrade tryptophan. Proc Natl Acad Sci USA 1984;81:908-12.