-
1
-
-
0029670281
-
Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
-
Urdiales JL, Morata P, Nunez De Castro I, Sanchez-Jimenez F. Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Lett 1996; 102:31-7.
-
(1996)
Cancer Lett
, vol.102
, pp. 31-37
-
-
Urdiales, J.L.1
Morata, P.2
Nunez De Castro, I.3
Sanchez-Jimenez, F.4
-
3
-
-
0031713769
-
In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells
-
Depenbrock H, Peter R, Faircloth GT, Manzanares I, Jimeno J, Hanauske AR. In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells. Br J Cancer 1998; 78:739-44.
-
(1998)
Br J Cancer
, vol.78
, pp. 739-744
-
-
Depenbrock, H.1
Peter, R.2
Faircloth, G.T.3
Manzanares, I.4
Jimeno, J.5
Hanauske, A.R.6
-
5
-
-
18444411949
-
Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine
-
Erba E, Bassano L, Di Liberti G, Muradore I, Chiorino G, Ubezio P, Vignati S, Codegoni A, Desiderio MA, Faircloth G, Jimeno J, D'Incalci M. Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine. Br J Cancer 2002; 86:1510-7.
-
(2002)
Br J Cancer
, vol.86
, pp. 1510-1517
-
-
Erba, E.1
Bassano, L.2
Di Liberti, G.3
Muradore, I.4
Chiorino, G.5
Ubezio, P.6
Vignati, S.7
Codegoni, A.8
Desiderio, M.A.9
Faircloth, G.10
Jimeno, J.11
D'Incalci, M.12
-
6
-
-
0041733458
-
Effect of Aplidin in acute lymphoblastic leukaemia cells
-
Erba E, Serafini M, Gaipa G, Tognon G, Marchini S, Celli N, Rotilio D, Broggini M, Jimeno J, Faircloth GT, Biondi A, D'Incalci M. Effect of Aplidin in acute lymphoblastic leukaemia cells. Br J Cancer 2003; 89:763-73.
-
(2003)
Br J Cancer
, vol.89
, pp. 763-773
-
-
Erba, E.1
Serafini, M.2
Gaipa, G.3
Tognon, G.4
Marchini, S.5
Celli, N.6
Rotilio, D.7
Broggini, M.8
Jimeno, J.9
Faircloth, G.T.10
Biondi, A.11
D'Incalci, M.12
-
7
-
-
0037766254
-
In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: A rational basis for clinical development
-
Bresters D, Broekhuizen AJ, Kaaijk P, Faircloth GT, Jimeno J, Kaspers GJ. In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: A rational basis for clinical development. Leukemia 2003; 17:1338-43.
-
(2003)
Leukemia
, vol.17
, pp. 1338-1343
-
-
Bresters, D.1
Broekhuizen, A.J.2
Kaaijk, P.3
Faircloth, G.T.4
Jimeno, J.5
Kaspers, G.J.6
-
8
-
-
0002375468
-
Marine depsipeptides with activity against solid tumour models
-
Paris
-
Faircloth G, Perez J, Fernandez JLSP, Avila J, Garcia M, Erba E, D'Incalci M, Canedo A, Garcia de Quesada T, Jimeno J. Marine depsipeptides with activity against solid tumour models [abstract]. Paris: Prooceedings 8th ECCO Congress, 1995:529.
-
(1995)
Prooceedings 8th ECCO Congress
, pp. 529
-
-
Faircloth, G.1
Perez, J.2
Fernandez, J.L.S.P.3
Avila, J.4
Garcia, M.5
Erba, E.6
D'Incalci, M.7
Canedo, A.8
Garcia De Quesada, T.9
Jimeno, J.10
-
9
-
-
0001944650
-
Dehydrodidemnin B (DDB) a new marine derived antitumour agent (MDA) with activity against experimental tumour models
-
Faircloth G, Rinehart K, Nunez de Castro I, Jimeno J. Dehydrodidemnin B (DDB) a new marine derived antitumour agent (MDA) with activity against experimental tumour models [abstract]. Ann Oncol 1996; 7:34.
-
(1996)
Ann Oncol
, vol.7
, pp. 34
-
-
Faircloth, G.1
Rinehart, K.2
Nunez De Castro, I.3
Jimeno, J.4
-
10
-
-
0021368081
-
Biochemical and cellular effects of didemnins A and B
-
Crampton SL, Adams EG, Kuentzel SL, Li LH, Badiner G, Bhuyan BK. Biochemical and cellular effects of didemnins A and B. Cancer Res 1984; 44:1796-801.
-
(1984)
Cancer Res
, vol.44
, pp. 1796-1801
-
-
Crampton, S.L.1
Adams, E.G.2
Kuentzel, S.L.3
Li, L.H.4
Badiner, G.5
Bhuyan, B.K.6
-
11
-
-
8944252332
-
Structure - Activity relationships of the didemnins
-
Sakai R, Rinehart KL, Kishore V, Kundu B, Faircloth G, Gloer JB, Carney JR, Namikoshi M, Sun F, Hughes Jr RG, Garcia Gravalos D, de Quesada TG, Wilson GR, Heid RM. Structure - activity relationships of the didemnins. J Med Chem 1996; 39:2819-34.
-
(1996)
J Med Chem
, vol.39
, pp. 2819-2834
-
-
Sakai, R.1
Rinehart, K.L.2
Kishore, V.3
Kundu, B.4
Faircloth, G.5
Gloer, J.B.6
Carney, J.R.7
Namikoshi, M.8
Sun, F.9
Hughes Jr., R.G.10
Garcia Gravalos, D.11
De Quesada, T.G.12
Wilson, G.R.13
Heid, R.M.14
-
12
-
-
0028300782
-
GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1alpha
-
Crews CM, Collins JL, Lane WS, Snapper ML, Schreiber SL. GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1alpha. J Biol Chem 1994; 269:15411-4.
-
(1994)
J Biol Chem
, vol.269
, pp. 15411-15414
-
-
Crews, C.M.1
Collins, J.L.2
Lane, W.S.3
Snapper, M.L.4
Schreiber, S.L.5
-
13
-
-
0037265805
-
Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4
-
Broggini M, Marchini S, Galliera E, Borsotti P, Taraboletti G, Erba E, Sironi M, Jimeno J, Faircloth GT, Giavazzi R, D'Incalci M. Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4. Leukemia 2003; 17:52-9.
-
(2003)
Leukemia
, vol.17
, pp. 52-59
-
-
Broggini, M.1
Marchini, S.2
Galliera, E.3
Borsotti, P.4
Taraboletti, G.5
Erba, E.6
Sironi, M.7
Jimeno, J.8
Faircloth, G.T.9
Giavazzi, R.10
D'Incalci, M.11
-
14
-
-
1842852886
-
Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines
-
Marchini S, Chiorino G, Faircloth GT, D'Incalci M. Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines. J Biol Regul Homeost Agents 2002; 16:241-8.
-
(2002)
J Biol Regul Homeost Agents
, vol.16
, pp. 241-248
-
-
Marchini, S.1
Chiorino, G.2
Faircloth, G.T.3
D'Incalci, M.4
-
15
-
-
0013094994
-
A phase I and pharmacokinetic study of aplidine (APL) given as a 24-hour continuous infusion every other week (q2w) in patients (pts) with solid tumor (ST) and lymphoma (NHL)
-
Amsterdam
-
Raymond E, Ady-Vago N, Baudin E, Ribrag V, Faivre SLF, Wright T, Lopez Lazaro L, Guzman C, Jimeno J, Ducreux M, Chevalier T, Armand JP. A phase I and pharmacokinetic study of aplidine (APL) given as a 24-hour continuous infusion every other week (q2w) in patients (pts) with solid tumor (ST) and lymphoma (NHL) [abstract]. Amsterdam: Proceedings 11th NCI-EORTC-AACR Symposium, 2000:86.
-
(2000)
Proceedings 11th NCI-EORTC-AACR Symposium
, pp. 86
-
-
Raymond, E.1
Ady-Vago, N.2
Baudin, E.3
Ribrag, V.4
Faivre, S.L.F.5
Wright, T.6
Lopez Lazaro, L.7
Guzman, C.8
Jimeno, J.9
Ducreux, M.10
Chevalier, T.11
Armand, J.P.12
-
16
-
-
0000165435
-
Phase I and pharmacokinetic study of aplidine (APL) given as a 24-hour continuous infusion every other week (q2w) in patients (pts) with solid tumor (ST) and lymphoma (NHL)
-
San Francisco
-
Armand JP, Ady-Vago N, Faivre S, Chieze S, Baudin E, Ribrag V, Lecot F, Iglesias L, Lopez-Lazaro L, Guzman C, Jimeno J, Ducreux M, Le Chevalier T, Raymond E. Phase I and pharmacokinetic study of aplidine (APL) given as a 24-hour continuous infusion every other week (q2w) in patients (pts) with solid tumor (ST) and lymphoma (NHL) [abstract]. San Francisco: Proceedings 37th ASCO Annual Meeting, 2001:20:120a.
-
(2001)
Proceedings 37th ASCO Annual Meeting
, vol.20
-
-
Armand, J.P.1
Ady-Vago, N.2
Faivre, S.3
Chieze, S.4
Baudin, E.5
Ribrag, V.6
Lecot, F.7
Iglesias, L.8
Lopez-Lazaro, L.9
Guzman, C.10
Jimeno, J.11
Ducreux, M.12
Le Chevalier, T.13
Raymond, E.14
-
17
-
-
25344458004
-
Phase I clinical and pharmacokinetic study of the marine compound aplidine (APL) administered as a 3 hour infusion every 2 weeks
-
Orlando
-
Ciruelos Gil EM, Twelves C, Dominguez MJ, McKay H, Anthony A, Castellanos D, Bezares S, Ruiz A, Lopez-Lazaro L, Jimeno J, Celli N, Cotes-Funes H, Paz-Ares L. Phase I clinical and pharmacokinetic study of the marine compound aplidine (APL) administered as a 3 hour infusion every 2 weeks. Orlando: Proceedings 38th ASCO Annual Meeting, 2002:106a.
-
(2002)
Proceedings 38th ASCO Annual Meeting
-
-
Ciruelos Gil, E.M.1
Twelves, C.2
Dominguez, M.J.3
McKay, H.4
Anthony, A.5
Castellanos, D.6
Bezares, S.7
Ruiz, A.8
Lopez-Lazaro, L.9
Jimeno, J.10
Celli, N.11
Cotes-Funes, H.12
Paz-Ares, L.13
-
18
-
-
0034099849
-
Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
-
Erba E, Bergamaschi D, Bassano L, Ronzoni S, Di Liberti G, Muradore I, Vignati S, Faircloth G, Jimeno J, D'Incalci M. Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743). Br J Cancer 2000; 82:1732-9.
-
(2000)
Br J Cancer
, vol.82
, pp. 1732-1739
-
-
Erba, E.1
Bergamaschi, D.2
Bassano, L.3
Ronzoni, S.4
Di Liberti, G.5
Muradore, I.6
Vignati, S.7
Faircloth, G.8
Jimeno, J.9
D'Incalci, M.10
-
19
-
-
0842324688
-
Determination of aplidin, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection
-
Celli N, Mariani B, Di Carlo F, Zucchetti M, Lopez-Lazaro L, D'Incalci M, Rotilio D. Determination of aplidin, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection. J Pharm Biomed Anal 2004; 34:619-30.
-
(2004)
J Pharm Biomed Anal
, vol.34
, pp. 619-630
-
-
Celli, N.1
Mariani, B.2
Di Carlo, F.3
Zucchetti, M.4
Lopez-Lazaro, L.5
D'Incalci, M.6
Rotilio, D.7
-
20
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2002; 2:48-58.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
21
-
-
0026674983
-
Peptide transport by the multidrug resistance pump
-
Sharma RC, Inoue S, Roitelman J, Schimke RT, Simoni RD. Peptide transport by the multidrug resistance pump. J Biol Chem 1992; 267:5731-4.
-
(1992)
J Biol Chem
, vol.267
, pp. 5731-5734
-
-
Sharma, R.C.1
Inoue, S.2
Roitelman, J.3
Schimke, R.T.4
Simoni, R.D.5
-
22
-
-
0028247250
-
Interaction of bioactive hydrophobic peptides with the human multidrug transporter
-
Sarkadi B, Muller M, Homolya L, Hollo Z, Seprodi J, Germann UA, Gottesman MM, Price EM, Boucher RC. Interaction of bioactive hydrophobic peptides with the human multidrug transporter. Faseb J 1994; 8:766-70.
-
(1994)
Faseb J
, vol.8
, pp. 766-770
-
-
Sarkadi, B.1
Muller, M.2
Homolya, L.3
Hollo, Z.4
Seprodi, J.5
Germann, U.A.6
Gottesman, M.M.7
Price, E.M.8
Boucher, R.C.9
-
23
-
-
0029987548
-
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport
-
Sharom FJ, Yu X, DiDiodato G, Chu JW. Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport. Biochem J 1996; 320(Pt 2):421-8.
-
(1996)
Biochem J
, vol.320
, Issue.2 PART
, pp. 421-428
-
-
Sharom, F.J.1
Yu, X.2
DiDiodato, G.3
Chu, J.W.4
-
24
-
-
0028920219
-
Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores
-
Sharom FJ, DiDiodato G, Yu X, Ashbourne KJ. Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores. J Biol Chem 1995; 270:10334-41.
-
(1995)
J Biol Chem
, vol.270
, pp. 10334-10341
-
-
Sharom, F.J.1
DiDiodato, G.2
Yu, X.3
Ashbourne, K.J.4
-
25
-
-
0032144087
-
Linear and cyclic peptides as substrates and modulators of P-glycoprotein: Peptide binding and effects on drug transport and accumulation
-
Sharom FJ, Lu P, Liu R, Yu X. Linear and cyclic peptides as substrates and modulators of P-glycoprotein: Peptide binding and effects on drug transport and accumulation. Biochem J 1998; 333(Pt3):621-30.
-
(1998)
Biochem J
, vol.333
, Issue.3 PART
, pp. 621-630
-
-
Sharom, F.J.1
Lu, P.2
Liu, R.3
Yu, X.4
-
26
-
-
16844377759
-
Cyclosporin A is a broad-spectrum multidrug resistance modulator
-
Qadir M, O'Loughlin KL, Fricke SM, Williamson NA, Greco WR, Minderman H, Baer MR. Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clin Cancer Res 2005; 11:2320-6.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2320-2326
-
-
Qadir, M.1
O'Loughlin, K.L.2
Fricke, S.M.3
Williamson, N.A.4
Greco, W.R.5
Minderman, H.6
Baer, M.R.7
-
27
-
-
0023158059
-
Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26)
-
Danks MK, Yalowich JC, Beck WT. Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26). Cancer Res 1987; 47:1297-301.
-
(1987)
Cancer Res
, vol.47
, pp. 1297-1301
-
-
Danks, M.K.1
Yalowich, J.C.2
Beck, W.T.3
-
28
-
-
6944232399
-
Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin
-
Losada A, Lopez-Oliva JM, Sanchez-Puelles JM, Garcia-Fernandez LF. Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin. Br J Cancer 2004; 91:1405-13.
-
(2004)
Br J Cancer
, vol.91
, pp. 1405-1413
-
-
Losada, A.1
Lopez-Oliva, J.M.2
Sanchez-Puelles, J.M.3
Garcia-Fernandez, L.F.4
|