Determination of Aplidin®, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 34, Issue 3, 2004, Pages 619-630

  Celli, Nicola ^a   Mariani, Barbara ^a   Di Carlo, Francesco ^a   Zucchetti, Massimo ^a   Lopez Lazaro, Luis ^b   D'Incalci, Maurizio ^a   Rotilio, Domenico ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b PHARMAMAR S A   (Spain)

Author keywords

Aplidin ; Cytotoxic drug; Didemnin B; Distribution in blood

Indexed keywords

ACETONITRILE; ANTINEOPLASTIC AGENT; CARBON; CHLOROFORM; DEHYDRODIDEMNIN B; DIDEMNIN B; WATER; CYCLOPEPTIDE; DEPSIPEPTIDE;

ANTINEOPLASTIC ACTIVITY; APLIDIUM ALBICANS; ARTICLE; BLOOD; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DENSITY GRADIENT; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; DRUG STABILITY; DRUG URINE LEVEL; ELECTROSPRAY; FREEZING; HUMAN; IONIZATION; LINEAR ENERGY TRANSFER; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PHASE SEPARATION; PHYTOPLANKTON; PRECIPITATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REACTION ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; STANDARD; TANDEM MASS SPECTROMETRY; TECHNIQUE; TEMPERATURE DEPENDENCE; THAWING; THERMODYNAMICS; ANIMAL; ELECTROSPRAY MASS SPECTROMETRY; METHODOLOGY; URINE; UROCHORDATA;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DEPSIPEPTIDES; HUMANS; PEPTIDES, CYCLIC; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UROCHORDATA;

EID: 0842324688     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00557-0     Document Type: Article

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