Vitamin D analogs, 20-Epi-22-oxa-24a,26a,27a,-trihomo-1α,25(OH)2-vitamin D3, 1,24(oh)2-22-ene-24-cyclopropyl-vitamin D3 and 1α,25(OH)2-lumisterol3 prime NB4 leukemia cells for monocytic differentiation via nongenomic signaling pathways, involving calcium and calpain

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4779-4788

  Berry, D M ^a   Meckling Gill, K A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,25 DIHYDROXY LUMISTEROL 3; 1BETA 25 DIHYDROXYVITAMIN D3; CALCIPOTRIOL; CALCIUM; CALPAIN; CALPASTATIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; LEXACALCITOL; PROTEIN KINASE C; PROTEINASE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CANCER; CELL DIFFERENTIATION; CELL MATURATION; ENZYME ACTIVITY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MONOCYTE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PSORIASIS; RECEPTOR BINDING;

EID: 0033305290     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7041     Document Type: Article

References (66)

1. 3 analogs: A unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells
2. 3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20)
3. 3 and its analogues on induction of apoptosis in breast cancer cells
4. EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells
5. 3 in growth regulation of cancer cell lines
6. 3
7. Growth regulation of human colon adenocarcinoma-derived cells by calcium, vitamin D and epidermal growth factor
8. 3 on primary prostatic cells
9. Three synthetic vitamin D analogues induce prostate-specific phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion
10. 3 analogs on clonal proliferation of human prostatic cancer cell lines
11. 3 induces differentiation of human myeloid leukemia cells
12. 3 induces a myelomonocytic phenotype with enhanced effector cell function in the HL-60 promyelocytic cell line
13. 19-nor Vitamin D analogs: A new class of potent inhibitors of proliferation and inducers of differentiation in human myeloid leukemia cell lines
14. 3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells
15. Structure-function relationships in the vitamin D endocrine system
16. 3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor
17. 3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteocarcinoma cells
18. 3 on the phosphoinositide metabolism in rat enterocytes
19. 3 and calcium and phospholipids in isolated rat nuclei
20. 3
21. 3 which mediates rapid activation of protein kinase C
22. 3 (as a 6-s-cis analog) stimulates non-genomic but not genomic biologic responses
23. 2 vitaminD3: Analogs are able to functionally differentiate between nuclear and membrane receptors
24. 3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic responses and that neither 6-s-cis nor 6-s-trans locked analogs are preferred for genomic biological responses
25. 2D3: Past, present and future
26. 3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia
27. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
28. Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia
29. All-trans retinoic acid in acute promyelocytic leukemia
30. 3: In vivo and in vitro effects on human preleukemic and leukemic cells
31. 3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades
32. 3 stimulates expression and translocation of protein kinase Cα and δ via a non-genomic mechanism and rapidly induces phosphorylation of a 33kDa protein in acute promyelocytic NB4 cells
33. 3
34. 3 is independent of nuclear receptor binding
35. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
36. 2+ is necessary for thrombin-induced platelet activation
37. Inhibition of IκB-α and IκB-β proteolysis by calpain inhibitor I blocks nitric oxide synthesis
38. 3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma
39. Vitamin D metabolites change the phenotype of monoblastic U937 cells
40. 3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes
41. 3 and phorbol-12-myristate-13-acetate
42. A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia
43. 3 analogs: Effect on leukemic clonal growth and differentiation, and on serum calcium levels
44. 3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor
45. 3 analogues: A novel class of potent regulators of cell growth and immune responses
46. 3 are associated with enhanced activation of the vitamin D receptor
47. 3 analogues and their 20-epi homologues with the vitamin D receptor
48. Synthesis of MC-903: A biologically active vitamin D metabolite analogue
49. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-β II,-ε, -ζ and -η
50. Nuclear translocation of β11 PKC isoenzymes in phorbol-ester-stimulated KM-3 pre-B human leukemic cells
51. 3 regulation of protein kinase C levels and activity
52. Stimulation of phosphorylation of mitogen-activated protein kinase by 1α,25-dihydroxyvitamin D3 in promyelocytic NB4 leukemia cells: A structure-function study
53. 2+ -independent isoforms of protein kinase C in rat colonocytes
54. 2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line
55. Changes in calcium influx affect the differentiation of murine erythroleukaemia cells
56. 3
57. Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation
58. Specific increase in calcium-activated neutral protease with low calcium sensitivity (m-calpain) in proerythroblastic K562 cell line cells induced to differentiation by phorbol 12-myristate 13-acetate
59. Modulation of cellular signals by calpain
60. Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain
61. 3 and its analogs
62. 3
63. Immunological properties of vitamin D analogues and metabolites
64. 3 analog structure-function assessment of the rapid stimulation of intestinal calcium absorption (transcaltachia)
65. Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo
66. 3-effects on cell growth regulation in vitro and calcium metabolism in vivo