Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: A transthoracic Doppler and myocardial contrast echocardiography study

Heart

Volumn 92, Issue 2, 2006, Pages 208-212

  Galiuto, Leonarda ^a,b   Lotrionte, M ^b   Crea, F ^b   Anselmi, A ^c   Biondi Zoccai, G G L ^b   De Giorgio, F ^b   Baldi, A ^d   Baldi, F ^d   Possati, G ^e   Gaudino, M ^e   Vetrovec, G W ^f   Abbate, A ^f  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

^f VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; SONOVUE;

AGED; AORTA STENOSIS; APOPTOSIS; ARTICLE; BLOOD FLOW VELOCITY; CLINICAL ARTICLE; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORRELATION ANALYSIS; DIASTOLE; DISEASE SEVERITY; DOPPLER ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; HUMAN; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TRANSTHORACIC ECHOCARDIOGRAPHY;

AGED; AORTIC VALVE STENOSIS; APOPTOSIS; BLOOD FLOW VELOCITY; CORONARY CIRCULATION; ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HUMANS; MALE; MICROCIRCULATION; MYOCYTES, CARDIAC;

EID: 31144444536     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2005.062422     Document Type: Article

References (24)

1. Carabello BA. Aortic stenosis. N Engl J Med 2002;346:677-82.
2. Schwartz F, Baumann P, Manthey J, et al. The effect of aortic valve replacement on survival. Circulation 1982;66:1105-10.
3. Johnson LL, Sciacca RR, Ellis K, et al. Reduced left ventricular myocardial blood flow per unit mass in aortic stenosis. Circulation 1978;57:582-90.
4. Hein S, Arnon E, Kostin S, et al. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 2003;107:984-91.
5. Ding B, Price RL, Goldsmith EC, et al. Left ventricular hypertrophy in ascending aortic stenosis mice: anoikosis and the progression to early failure. Circulation 2000;101:2854-62.
6. Hirota H, Chen J, Betz U, et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 1999;97:189-98.
7. Yamamoto S, Sawada K, Shimomura H, et al. On the nature of cell death during remodelling of hypertrophied human myocardium. J Mol Cell Cordiol 2000;32:161-75.
8. Teiger E, Than VD, Richard L, et al. Apoptosis in pressure overload-induced heart hypertrophy in the rat. J Clin Invest 1996;97:2891-7.
9. Abbate A, Biondi-Zoccai GG, Bussani R, et al. Increased myocardial apoptosis in patients with unfavorable left ventricular remodelling and early symptomatic post-infarction heart failure. J Am Coll Cardiol 2003;41:753-60.
10. Abbate A, Biondi-Zoccai GG, Baldi A. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodelling. J Cell Physiol 2002;193:145-53.
11. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-67.
12. Caiati C, Montaldo C, Zedda N, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol 1999;34:1193-200.
13. Wei K, Jayaweera AR, Firoozan S, et al. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998;97:473-83.
14. Caiati C, Zedda N, Montaldo C, et al. New noninvasive method for coronary flow reserve assessment: contrast-enhanced transthoracic second harmonic echo Doppler. Circulation 1999;99:771-8.
15. Galiuto L, Sestito A, Lotrionte M, et al. Non invasive evaluation of coronary flow reserve in the left anterior descending coronary artery in patients with syndrome X: a transthoracic Doppler and myocardial contrast echo study (abstract). Eur Heart J 2004;25(suppl):2236.
16. Rajappan K, Rimoldi OE, Dutka DP, et al. Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries. Circulation 2002;105:470-6.
17. Schwartzkopff B, Mundenke M, Strauer BE. Alterations of the architecture of subendocardial arterioles in patients with hypertrophic cardiomyopathy and impaired coronary vasodilator reserve: a possible cause in myocardial ischemia. J Am Coll Cardiol 1998;31:1089-96.
18. Galderisi M, de Simone G, Cicala S, et al. Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass. J Hypertens 2003;21:2183-8.
19. Galiuto L, Lombardo A, Maseri A, et al. Temporal evolution and functional outcome of no reflow: sustained and spontaneously reversible patterns following successful coronary recanalisation. Heart 2003;89:731-7.
20. Fallavollita JA, Lim H, Canty JM Jr. Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium. J Mol Cell Cardiol 2001;33:1937-44.
21. Wencker D, Chandra M, Nguyen K, et al. Mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 2003;111:1497-504.
22. Chandrashekhar Y, Sen S, Anway R, et al. Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodelling in rats with myocardial infarction. J Am Coll Cardiol 2004;43:295-301.
23. Urbanek K, Quaini F, Tasca G, et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A 2003;100:10440-5.
24. Li Z, Bing OH, Long X, et al. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol 1997;272:H2313-9.