The mechanisms for HCV NS3 protein upregulating cell proliferation in human hepatocytes

Progress in Biochemistry and Biophysics

Volumn 32, Issue 10, 2005, Pages 991-997

  Li, Bo ^a   Feng, De Yun ^a   Cheng, Rui Xue ^a   Sun, Shu Yan ^a   He, Qiong Qiong ^a   Hu, Zhong Liang ^a   Zheng, Hui ^a   Wen, Ji Fang ^a  

^a Central South University   (China)

Author keywords

Hepatitis C virus NS3 protein; Hepatocytes; MAPK; Transpcrition factors

Indexed keywords

EUKARYOTA; HEPATITIS C VIRUS; MUS MUSCULUS;

EID: 31144442941     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Sakamuro D. Hepatitis C virus nonstructural protein NS3 transformsNIH/3T3 cells. J Virol, 1995, 69 (6): 3893-3896
2. He Q Q, Cheng R X, Sun Y, et al. Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 C-terminal deleted protein. World J Gastroenterol, 2003, 9 (3): 474-478
3. Feng D Y, Zheng H, Yan Y H, et al. Natl Med J China, 1998, 78 (4): 278-280
4. Kolykhalov A A, Agapov E V, Blight K J, et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science, 1997, 277 (5325): 570-574
5. Kwun H J, Jung E Y, Ahn J Y, et al. P53-dependent transcriptional repression of p21 (waf 1) by hepatitis C virus NS3. J Gen Virol, 2001, 82 (Pt 9): 2235-2241
6. Zemel R, Gerechet S, Greif H, et al. Cell transformation induced by hepatitis C virus NS3 serine protease. J Viral Hepatitis, 2001, 8 (2): 96-102
7. Siavoshian S, Abraham J D, Kieny M P, et al. HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines. Arch Virol, 2004, 149 (2): 323-336
8. Sewing A, Wiseman B, Lloyd A, et al. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol, 1997, 17 (9): 5588-5597
9. MAPK are required for fibroblast proliferation. Proc Natl Acad Sci USA, 1993, 90 (18): 8319-8323
10. Zhang W, Liu H T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res, 2002, 12 (1): 9-18
11. Kerkhoff E, Rapp U R. Cell cycle targets of Ras/Raf signalling. Oncogene, 1998, 17 (11 Reviews): 1457-1462
12. Yao Z Q, Eisen-Vandervelde A, Ray S, et al. HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1. Virology, 2003, 314 (1): 271-282
13. Li B, Feng D Y, Cheng R X, et al. Natl Med J China, 2005, 85 (18): 1243-1248
14. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene, 2001, 20 (19): 2390-2400
15. Treinies I, Paterson H F, Hooper S, et al. Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis. Mol Cell Biol, 1999, 19 (1): 321-329
16. Kovary K, Bravo R. The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol, 1991, 11 (9): 4466-4472
17. Hassan M, Ghozlan H, Abdel-Kader O. Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth. Virology, 2005, 333 (2): 324-336
18. Zhu D H, Wang J B. Chin J Cancer Prevention and Treatment, 1979, 5: 7-9
19. Waris G, Turkson J, Hassanein T, et al. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol, 2005, 79 (3): 1569-1580
20. Fimia G M, Evangelisti C, Alonzi T, et al. Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation. J Virol, 2004, 78 (23): 12809-12816
21. Dolganiuc A, Oak S, Kodys K, et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology, 2004, 127 (5): 1513-1524
22. Kato N, Yoshida H, Kioko Ono-Nita S, et al. Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer. Hepatology, 2000, 32 (2): 405-412
23. Di Bisceglie A M. Hepatitis C and hepatocellular carcinoma. Hepatology, 1997, 26 (3 Suppl 1): 34S-38S