Results of radiotherapy of subfoveal neovascularization with 16 and 20Gy

Eye

Volumn 19, Issue 11, 2005, Pages 1151-1156

  Hoeller, Ulrike ^a,b   Fuisting, B ^a   Schwartz, R ^a   Roeper, B ^a   Richard, G ^a   Alberti, W ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b VIVANTES KLINIKUM NEUKÖLLN   (Germany)

Author keywords

ARMD; Choroidal neovascularization; Radiotherapy

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; HUMAN; LACRIMATION; MAJOR CLINICAL STUDY; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION SICKNESS; RETINA MACULA AGE RELATED DEGENERATION; RISK FACTOR; SUBRETINAL NEOVASCULARIZATION; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 31044453066     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/sj.eye.6701743     Document Type: Article

References (40)

1. Leibowitz HM, Krueger DE, Maunder LR, Milton RC, Kini MM, Kahn HA et al. The Framingham Eye Study monograph. Surv Ophthalmol 1980; 24(Suppl): 335-410.
2. Bergink GJ, Hoyng CB, van der Maazen RW, Vingerling JR, van Daal WA, Deutman AF. Visual acuity and scar size in eyes with age-related subfoveal choroidal neovascular lesions, 30 months after radiation therapy. Doc Ophthalmol 1996; 92: 61-75.
3. Chakravarthy U, Houston RF, Archer DB. Treatment of age-related subfoveal neovascular membranes by teletherapy: A pilot study. Br J Ophthalmol 1993; 77: 265-273.
4. Hart PM, Chakravarthy U, MacKenzie G, Archer DB, Houston RF. Teletherapy for subfoveal choroidal neovascularisation of age-related macular degeneratio: Results of follow up in a non-randomised study. Br J Ophthalmol 1996; 80: 1046-1050.
5. Mauget-Faysse M, Chiquet C, Milea D, Romestaing P, Gèrard JP, Martin P et al. Long term results of radiotherapy for subfoveal choroidal neovascularistion in age related macular degeneration. Br J Ophthalmol 1999; 83: 923-928.
6. Gripp S, Stammen J, Petersen C, Hartmann A, Willers R, Althaus C. Radiotherapy in age-related macula degeneration. Int J Radiat Oncol Biol Phys 2002; 52: 489-495.
7. Bergink GJ, Hoyng CB, van der Maazen RWM, Vingerling JR, van Daal WA, Deutman AF. A randomized controlled clinical trial on the efficacy of radiation therapy in the control of subfoveal choroidal neovascularization in age-related macular degeneration: Radiation versus observation. Graefe's Arch Clin Exp Ophthlamol 1998; 236: 321-325.
8. Fine SL, Maguire MG. It is not time to abandon radiotherapy for neovascular age-related macular degeneration. Arch Ophthalmol 2001; 119: 275-276.
9. Bressler NM, Frost LA, Bressler SB, Murphy RP, Fine SL. Natural course of poorly defined choroidal neovascularization associated with macular degeneration. Arch Ophthalmol 1988; 106: 1537-1542.
10. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal lesions in age-related macular degeneration: Updated findings from two clinical trials. Arch Ophthalmol 1993; 111: 1200-1209.
11. Frank RN, Amin RH, Elliott D, Puklin JE, Abrams GW. Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol 1996; 122: 393-403.
12. Holz FG, Pauleikhoff D (eds). Altersabhängige Makuladegeneration. Springer: Berlin, 1997.
13. Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol 1997; 81: 154-162.
14. Pauleikhoff D, Harper CA, Marshall J, Bird AC. Aging changes in Bruch's membrane. A histochemical and morphologic study. Ophthalmology 1990; 97: 171-178.
15. Killingsworth HC, Sarks JF, Sarks SH. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye 1990; 4: 613-621.
16. Lopez PF, Grossniklaus HE, Lambert MH, Aaberg TM, Capone A, Sternberg P et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol 1991; 112: 647-656.
17. Chakravarthy U, Biggart JH, Gardiner TA, Archer DB, Maguire CJ. Focal irradiation of perforating eye injuries: Minimum effective dose and optimum time of irradiation. Curr Eye Res 1989; 8: 1241-1250.
18. Chakravarthy U, Gardiner TA, Archer DB, Maguire CJ. A light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds. Curr Eye Res 1989; 8: 337-348.
19. De Gowin RL, Lewis LJ, Hoak JC, Mueller AL, Gibson DP. Radiosensitivity of human endothelial cells in culture. J Lab Clin Med 1974; 81: 42-48.
20. Rosander K, Zackrisson B. DNA damage in human endothelial cells after irradiation in anoxia. Acta Oncol 1995; 34: 111-116.
21. Hosoi Y, Yamamoto Y, Ono T, Sakamoto K. Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation. Int J Radiat Oncol Biol Phys 1993; 63: 631-638.
22. Mooteri SN, Podolski JL, Drab EA, Saclarides TJ, Onoda JM, Kantak SS. WR 1065 and radioprotection of vascular endothelial cells. II Morphology. Radiat Res 1996; 145: 217-224.
23. Rubin DB, Drab EA, Kang HJ, Baumann FE, Blazek ER. WR 1065 and radioprotection of vascular endothelial cells. I Cell proliferation, DNA synthesis and damage. Radiat Res 1996; 145: 210-216.
24. Waters CM, Taylor JM, Molteni A, Ward WF. Dose response effects of radiation on the permeability of endothelial cells in culture. Radiat Res 1996; 146: 321-328.
25. Langley RE, Bump EA, Quartuccio SG, Medeiros D, Braunhut SJ. Radiation-induced apoptosis in microvascular endothelial cells. Br J Cancer 1997; 75: 666-672.
26. Archambeau JO, Mao XW, Yonemoto LT, Slater JD, Friedrichsen E, Teichman S et al. What is the role of radiation in the treatment of subfoveal membranes. Review of radiobiologic, pathologic, and other considerations to initiate a multimodality discussion. Int J Radiat Oncol Biol Phys 1998; 40: 1125-1136.
27. Miyamoto H, Kimura H, Yasukawa T, Honda Y, Tabata Y, Ikada Y et al. Effect of focal X-ray irradiation on experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 1999; 40: 1496-1502.
28. Spaide RF, Guyer DR, McCormick B, Yannuzzi LA, Burke K, Mendelsohn M et al. External beam radiation therapy for choroidal neovascularization. Ophthalmology 1998; 105: 24-30.
29. Postgens H, Bodanowitz S, Kroll P. Low dose radiation therapy for age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 1997; 235: 656-661.
30. Prettenhofer U, Haas A, Mayer R, Oechs A, Pakisch B, Stranzl H et al. Role of radiotherapy in age-related macular degeneration: A prospective study. Strahlenther Onkol 1998; 174: 613-617.
31. Staar S, Krott R, Mueller RP, Bartz-Schmidt KU, Heimann K. External beam radiotherapy for subretinal neovascularization in age-related macular degeneration: Is this treatment efficient? Int J Radiat Oncol Biol Phys 1999; 45: 467-473.
32. RAD. A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related degeneration (RAD Study). Radiation therapy for age-related macular degeneration. Ophthalmol 1999; 106: 2239-2247.
33. Marcus DM, Sheils WC, Johnson MH, McIntosh SB, Leibach DB, Maguire A et al. External beam irradiation of subfoveal choroidal neovascularization of complicating age-related macular degeneration. Arch Ophthalmol 2001; 119: 171-180.
34. Schittkowski M, Schneider H, Grüschow K, Ziegler PG, Guthoff R, Fietkau R. 3 Jahre Erfahrung mit der niedrig dosierten fraktionierten perkutanen Teletherapie bei subfoveolären Neovaskularisationen. Strahlenther Onkol 2001; 177: 345-353.
35. Bergink GJ, Deutman AF, van den Brock JF, van Daal WA, van der Maazen RW. Radiation therapy for subfoveal choroidal neovascular membranes in age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 1994; 232: 591-598.
36. Stalmans P, Leys A, Van Limbergen E. External beam radiotherapy (20 Gy, 2 fractions) fails to control the growth of choroidal neovascularization in age-related macular degeneration: A review of 111 cases. Retina 1997; 17: 481-492.
37. Eter N, Schüller H, Spitznas M. Radiotherapy for age-related macular degeneration: Is there a benefit for classic CNV? Int Ophthalmol 2002; 24: 13-19.
38. Valmaggia C, Ries G, Ballinari P. Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: A randomized clinical trial. Am J Opthalmol 2002; 133: 521-529.
39. Yonemoto LT, Slater JD, Blacharski PB. Dose response in the treatment of subfoveal choroidal neovascularization in age-related macular degeneration: Results of a Phase I/II dose escalation study using proton radiotherapy. J Radiosurg 2000; 3: 47-54.
40. Thoelen A, Meister A, Bernasconi PF, Messmer EP. Radiotherapie von subretinalen Neovaskularisations-membranen bei altersabhängiger Makuladegeneration (AMD). Ophthalmologe 1998; 95: 691-698.