Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol

Parasitology International

Volumn 55, Issue 1, 2006, Pages 39-43

  Yabu, Yoshisada ^a   Suzuki, Takashi ^a   Nihei, Coh Ichi ^b,f   Minagawa, Nobuko ^c   Hosokawa, Tomoyoshi ^d   Nagai, Kazuo ^e   Kita, Kiyoshi ^b   Ohta, Nobuo ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^d Institute of Applied Biology   (Japan)

^e CHUBU UNIVERSITY   (Japan)

^f RIKEN   (Japan)

Author keywords

Ascofuranone; Chemotherapy; Intramuscular; Mouse; Trypanosoma vivax

Indexed keywords

ASCOFURANONE; GLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SINGLE DRUG DOSE; TRYPANOSOMA BRUCEI; TRYPANOSOMA VIVAX; TRYPANOSOMIASIS;

ANIMALS; DISEASE MODELS, ANIMAL; GLYCEROL; MALE; MICE; MICE, INBRED BALB C; SESQUITERPENES; TREATMENT OUTCOME; TRYPANOCIDAL AGENTS; TRYPANOSOMA VIVAX; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; ASCOCHYTA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA VIVAX;

EID: 31044443202     PISSN: 13835769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parint.2005.09.003     Document Type: Article

References (59)

1. P.R. Gardiner Recent studies of the biology of Trypanosoma vivax Adv Parasitol 28 1989 229 317
2. T.W. Jones, and A.M. Davila Trypanosoma vivax-out of Africa Trends Parasitol 17 2001 99 101
3. C.C. Wang Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis Annu Rev Pharmacol Toxicol 35 1995 93 127
4. A. Schonefeld, D. Rottcher, and S.K. Moloo The sensitivity to trypanocidal drugs of Trypanosoma vivax isolated in Kenya and Somalia Trop Med Parasitol 38 1987 177 180
5. V. Codjia, W. Mulatu, P.A. Majiwa, S.G. Leak, G.J. Rowlands, and E. Authie Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium Acta Trop 53 1993 151 163
6. S. Geerts, P.H. Holmes, M.C. Eisler, and O. Diall African bovine trypanosomiasis: the problem of drug resistance Trends Parasitol 17 2001 25 28
7. O.A. Ainanshe, F.W. Jennings, and P.H. Holmes Isolation of drug-resistant strains of Trypanosoma congolense from the lower Shabelle region of Southern Somalia Trop Anim Health Prod 24 1992 65 73
8. L. Sinyangwe, V. Delespaux, J. Brandt, S. Geerts, J. Mubanga, and N. Machila Trypanocidal drug resistance in eastern province of Zambia Vet Parasitol 119 2004 125 135
9. F.A.S. Kuzoe Current situation of African trypanosomiasis Acta Trop 54 1993 153 162
10. J. Keiser, A. Stich, and C. Burri New drugs for the treatment of human African trypanosomiasis: research and development Trends Parasitol 17 2001 42 49
11. J. Magae, T. Hosokawa, K. Ando, K. Nagai, and G. Tamura Antitumor protective property of an isoprenoid antibiotic, ascofuranone J Antibiot 35 1982 1547 1552
12. J. Magae, K. Nagai, K. Ando, M. Yamasaki, and G. Tamura Effects of an antitumor agent, ascofuranone, on the macromolecular syntheses of intact cells J Antibiot 36 1983 892 899
13. J. Magae, M. Hotta, K. Nagai, S. Suzuki, K. Ando, and M. Yamasaki Activation of natural cytotoxic activity and concomitant reduction of triglyceride content of murine spleen, treated with an antitumor antibiotic, ascofuranone J Antibiot 39 1986 676 681
14. J. Magae, S. Suzuki, K. Nagai, M. Yamasaki, K. Ando, and G. Tamura In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system Cancer Res 46 1986 1073 1078
15. J. Magae, K. Nagai, S. Suzuki, M. Yamasaki, K. Ando, and G. Tamura Macrophage-specific effect on lipid metabolism by an antibiotic, ascofuranone J Antibiot 40 1987 202 208
16. J. Magae, T. Hosokawa, Y. Matsuda, M. Hotta, J. Hayasaki, and K. Nagai Suppression of hypertriglyceridemia of Ehrlich carcinoma-bearing mice by an antibiotic, ascofuranone Cancer Res 47 1987 96 99
17. J. Magae, J. Hayasaki, Y. Matsuda, M. Hotta, T. Hosokawa, and S. Suzuki Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes J Antibiot 41 1988 959 965
18. J. Magae, K. Nagai, K. Ando, and G. Tamura Differentiation of mouse and human myeloid leukemia cells induced by an antitumor antibiotic, ascofuranone Agric Biol Chem 52 1988 3143 3147
19. N. Minagawa, Y. Yabu, K. Kita, K. Nagai, N. Ohta, and K. Meguro An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei Mol Biochem Parasitol 81 1996 127 136
20. Y. Yabu, N. Minagawa, K. Kita, K. Nagai, M. Honma, and S. Sakajo Oral and intraperitoneal treatment of Trypanosoma brucei brucei with a combination of ascofuranone and glycerol in mice Parasitol Int 47 1998 131 137
21. Y. Fukai, H. Amino, H. Hirawake, Y. Yabu, N. Ohta, and N. Minagawa Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli Comp Biochem Physiol C 124 1999 141 148
22. Y. Fukai, C. Nihei, Y. Yabu, T. Suzuki, N. Ohta, and N. Minagawa Strain-specific difference in amino acid sequences of trypanosome alternative oxidase Parasitol Int 51 2002 195 199
23. C. Nihei, Y. Fukai, and K. Kita Trypanosome alternative oxidase as a target of chemotherapy Biochim Biophys Acta 1587 2002 234 239
24. C. Nihei, Y. Fukai, K. Kawai, A. Osanai, Y. Yabu, and T. Suzuki Purification of active recombinant trypanosome alternative oxidase FEBS Lett 538 2003 35 40
25. Y. Yabu, A. Yoshida, T. Suzuki, C. Nihei, K. Kawai, and N. Minagawa The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice Parasitol Int 52 2003 155 164
26. T. Suzuki, C. Nihei, Y. Yabu, T. Hashimoto, M. Suzuki, and A. Yoshida Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone Parasitol Int 53 2004 235 245
27. A.B. Clarkson Jr., R.W. Grady, S.A. Grossman, R.J. McCallum, and F.H. Brohn Trypanosoma brucei brucei: a systematic screening for alternatives to the salicylhydroxamic acid-glycerol combination Mol Biochem Parasitol 3 1981 271 291
28. C. van der Meer, J.A. Versluijs-Broers, and F.R. Opperdoes Trypanosoma brucei: trypanocidal effect of salicylhydroxamic acid plus glycerol in infected rats Exp Parasitol 48 1979 126 134
29. C. vad der Meer, and J.A. Versluijs-Broers Trypanosoma brucei and T. vivax: salicylhydroxamic acid and glycerol treatment of acute and chronically infected rats Exp Parasitol 62 1986 98 113
30. C.E. Clayton, and P. Michels Metabolic compartmentation in African trypanosomes Parasitol Today 12 1996 465 471
31. P.A.M. Michels, V. Hannaert, and F. Bringaud Metabolic aspects of glycosomes in Trypanosomatidae-new data and views Parastol Today 16 2000 482 489
32. K. Vickerman, and D.A. Evans Studies on the ultrastructure and respiratory physiology of Trypanosoma vivax trypomastigote stages Trans R Soc Trop Med Hyg 68 1974 145
33. D.A. Evans, and M.F. Holland Effective treatment of Trypanosoma vivax infections with salicylhydroxamic acid (SHAM) Trans R Soc Trop Med Hyg 72 1978 203 204
34. D.A. Evans, and C.A. Brightman Pleomorphism and the problem of recrudescent parasitemia following treatment with salicylhydroxamic acid (SHAM) in African trypanosomiasis Trans R Soc Trop Med Hyg 74 1980 601 604
35. C. van der Meer, J.A. Versluijs-Broers, C.T. van Duin, T.S. van den Ingh, J. Nieuwenhuijs, and D. Zwart Pitfalls of salicylhydroxamic acid plus glycerol treatment of T. vivax infected goats Tropenmed Parasitol 31 1980 275 282
36. H. Sasaki, T. Hosokawa, M. Sawada, and K. Ando Isolation and structure of ascofuranone and ascofuranol, antibiotics with hypolipidemic activity J Antibiot 26 1973 676 680
37. J.D. Barry, and H. Gathuo Antigenic variation in Trypanosoma vivax: isolation of a serodome Parasitol 89 1984 49 58
38. P. Leeflang, J. Buys, and C. Blotkamp Studies on Trypanosoma vivax: infectivity and serial maintenance of natural bovine isolates in mice Int J Parasitol 6 1976 413 417
39. G.J. Vos, and P.R. Gardiner Antigenic relatedness of stocks and clones of Trypanosoma vivax from East and West Africa Parasitol 100 1900 101 106
40. A.L. de Gee, S.D. Shah, and J.J. Doyle Trypanosoma vivax: courses of infection with three stabilates in inbred mouse strains Exp Parasitol 54 1982 33 39
41. Z.Q. Zhang, C. Giroud, and T. Baltz In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, Melcy, quinapyramine and isometamidium Acta Trop 50 1991 101 110
42. A.G.M. Tielens, and J.J. Van Hellemond Difference in energy metabolism between Trypanosomatidae Parasitol Today 14 1998 265 271
43. N. Visser, and F.R. Opperdoes Glycolysis of Trypanosoma brucei Eur J Biochem 103 1980 623 632
44. V. Hannaert, and P.A.M. Michels Structure, function, and biogenesis of glycosomes in Kinetoplastida J Bioenerg Biomembr 26 1994 205 212
45. A.B. Clarkson Jr., and F.H. Brohn Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism Science 194 1976 204 206
46. +-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei Eur J Biochem 76 1977 29 39
47. R.W. Grady, E.J. Bienen, and A.B. Clarkson Jr. Esters of 3,4-dihydroxybenzoic acid, highly effective inhibitors of the sn-glycerol-3-phosphate oxidase of Trypanosoma brucei brucei Mol Biochem Parasitol 21 1986 55 63
48. R.W. Grady, E.J. Bienen, and A.B. Clarkson Jr. p-Alkyloxybenzhydroxamic acids, effective inhibitors of the trypanosome glycerol-3-phosphate oxidase Mol Biochem Parasitol 19 1986 231 240
49. A.B. Clarkson Jr., E.J. Bienen, G. Pollakis, and R.W. Grady Trypanocidal CoQ analogues: their effect on other mitochondrial system Comp Biochem Physiol B 94 1989 245 251
50. A.B. Clarkson Jr., E.J. Bienen, G. Pollakis, M. Saric, L. McIntosh, and R.W Grady Trypanosome alternative oxidase Chemotherapy for trypanosomiasis. Proceedings of a workshop held at ILRAD, Nairobi, Kenya 1989 43 48
51. A.B. Clarkson Jr., E.J. Bienen, G. Pollakis, and R.W. Grady Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase J Biol Chem 264 1989 17770 17776
52. E.J. Bienen, M. Saric, G. Pollakis, R.W. Grady, and A.B. Clarkson Jr. Mitochondrial development in Trypanosoma brucei brucei transitional bloodstream forms Mol Biochem Parasitol 45 1991 185 192
53. J.A. Kornblatt, J. Nthale, and F. McOdimba Purification of sn-glycerol-3-phosphate dehydrogenase from Trypanosoma brucei brucei Biochem Cell Biol 70 1992 136 141
54. R.W Grady, E.J. Bienen, H.A. Dieck, M. Saric, and A.B. Clarkson Jr. N-n-alkyl-3, 4-dihydroxybenzamides as inhibitors of the trypanosome alternative oxidase: activity in vitro and in vivo Antimicrob Agents Chemother 37 1993 1082 1085
55. J.W. Priest, and S.L. Hajduk Developmental regulation of mitochondrial biogenesis in Trypanosoma brucei J Bioenerg Biomembr 26 1994 179 191
56. M. Chaudhuri, W. Ajayi, S. Temple, and G.C. Hill Identification and partial purification of a stage-specific 33 kDa mitochondrial protein as the alternative oxidase of the Trypanosoma brucei brucei bloodstream trypomastigotes J Eukaryot Microbiol 42 1995 467 472
57. M. Chaudhuri, and G.C. Hill Cloning, sequencing, and functional activity of the Trypanosoma brucei brucei alternative oxidase Mol Biochem Parasitol 83 1996 125 129
58. F.R. Opperdoes Progress in human African trypanosomiasis, sleeping sickness 1999 Springer Paris 53 80
59. I. Kralova, D.J. Rigden, F.R. Opperdoes, and P.A. Michels Glycerol kinase of Trypanosoma brucei. Cloning, molecular characterization and mutagenesis Eur J Biochem 267 2000 2323 2333