Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone

Parasitology International

Volumn 53, Issue 3, 2004, Pages 235-245

  Suzuki, Takashi ^a   Nihei, Coh Ichi ^b,g   Yabu, Yoshisada ^a   Hashimoto, Tetsuo ^c   Suzuki, Mitsuko ^a   Yoshida, Ayako ^a   Nagai, Kazuo ^d   Hosokawa, Tomoyoshi ^e   Minagawa, Nobuko ^f   Suzuki, Shuichi ^b   Kita, Kiyoshi ^b   Ohta, Nobuo ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d CHUBU UNIVERSITY   (Japan)

^e Institute of Applied Biology   (Japan)

^f NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^g RIKEN   (Japan)

Author keywords

Alternative oxidase; Ascofuranone; Competitive inhibition; Phylogenetic analysis; Trypanosoma vivax

Indexed keywords

ALCOHOL DERIVATIVE; AMINO ACID; ANTITRYPANOSOMAL AGENT; ASCOFURANONE; ENZYME INHIBITOR; FURANONE DERIVATIVE; OXIDOREDUCTASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; ENZYME ANALYSIS; ESCHERICHIA COLI; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTOZOAL GENETICS; SEQUENCE HOMOLOGY; TRYPANOSOMA BRUCEI; TRYPANOSOMA VIVAX; TRYPANOSOMIASIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CATTLE; CLONING, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SESQUITERPENES; TRYPANOCIDAL AGENTS; TRYPANOSOMA VIVAX; TRYPANOSOMIASIS, AFRICAN; TRYPANOSOMIASIS, BOVINE;

BOS TAURUS; ESCHERICHIA COLI; GLOSSINA (PROPER); TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA VIVAX;

EID: 2442495286     PISSN: 13835769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parint.2004.02.001     Document Type: Article

References (27)

1. Gardiner P.R. Recent studies of the biology of Trypanosoma vivax. Adv Parasitol. 28:1989;229-317
2. Hoare C.A. The Trypanosomes of mammals. A zoological monograph. 1972;Blackwell Scientific Publications, Oxford
3. Stanny G., Peter H.H., Oumar D., Mark C.E. African bovine trypanosomiasis: the problem of drug resistance. Trends Parasitol. 17:2001;25-28
4. Chaudhuri M., Ajayi W., Temple S., Hill G.C. Identification and partial purification of a stage-specific 33 kDa mitochondrial protein as the alternative oxidase of the Trypanosoma brucei brucei bloodstream trypomastigotes. J Eukaryot Microbiol. 42:1995;467-472
5. Chaudhuri M., Hill G.C. Cloning, sequencing, and functional activity of the Trypanosoma brucei brucei alternative oxidase. Mol Biochem Parasitol. 83:1996;125-129
6. Nihei C., Fukai Y., Kita K. Trypanosome alternative oxidase as a target of chemotherapy. Biochim Biophys Acta. 1587:2002;234-239
7. Minagawa N., Yabu Y., Kita K., Nagai K., Ohta N., Meguro K., Sakajo S., et al. An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei. Mol Biochem Parasitol. 84:1997;271-280
8. Yabu Y., Minagawa N., Kita K., Nagai K., Honma M., Sakajo S., et al. Oral and intraperitoneal treatment of Trypanosoma brucei brucei with a combination of ascofuranone and glycerol in mice. Parasitol Int. 47:1998;131-137
9. van der Meer C., Versluijs-Broers J.A., van Duin C.T., van den Ingh T.S.G.A.M., Nieuwenhuijs J., Zwart D. Pitfalls of salicylhydroxamic acid plus glycerol treatment of Trypanosoma vivax infected goats. Tropenmed Parasitol. 31:1980;275-282
10. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory mannual. 2nd ed. 1989;Cold Spring Harbor Lavoratory Press
11. Fukai Y., Amino H., Hirawake H., Yabu Y., Ohta N., Minagawa N., et al. Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 124:1999;141-148
12. Hughey R., Krogh A. Hidden Markov models for sequence analysis: extension and analysis of the basic metod. Comput Appl Biosci. 12:1996;95-107
13. Adachi J., Hasegawa M. MOLPHY version 2.3: programs for molecular phylogenetics based on maximum likelihood. in "computer science monographs''. The Institute of Statistical Mathematics. 1996;28
14. Yang Z. PAML: a program package for phylogenetic analysis by maximum likelihood. Comput. Appl. Biosci. 13:1997;555-556
15. Nihei C., Nakayashiki T., Nakamura K., Inokuchi H., Gennis R.B., Kojima S., et al. Abortive assembly of succinate-ubiquinone reductase (complex II) in a ferrochelatase-deficient mutant of Escherichia coli. Mol Genet Genomics. 265:2001;394-404
16. Fukai Y., Nihei C., Yabu Y., Suzuki T., Ohta N., Minagawa N., et al. Strain-specific difference in amino acid sequences of trypanosome alternative oxidase. Parasitol Int. 51:2002;195-199
17. Bannai H., Tamada Y., Maruyama O., Nakai K., Miyano S. Extensive feature detection of N-terminal protein sorting signals. Bioinformatics. 18:2002;298-305
18. Magae J., Hosokawa T., Ando K., Nagai K., Tamura G. Antitumor protective property of an isoprenoid antibiotic, ascofuranone. J Antibiot (Tokyo). 35:1982;1547-1552
19. Magae J., Nagai K., Ando K., Yamasaki M., Tamura G. Effects of an antitumor agent, ascofuranone, on the macromolecular syntheses of intact cells. J Antibiot (Tokyo). 36:1983;892-899
20. Nihei C., Fukai Y., Kawai K., Osanai A., Yabu Y., Suzuki T., Ohta N., Minagawa N., Nagai K., Kita K. Purification of active trypanosome alternative oxidase. FEBS Lett. 538:2003;35-40
21. Dinant M., Baurain D., Coosemans N., Joris B., Matagne R.F. Characterization of two genes encoding the mitochondrial alternative oxidase in Chlamydomonas reinhardtii. Curr Genet. 39:2001;101-108
22. Meeuse B.J. Thermogenic respiration in aroids. Annu Rev Plant Physiol. 26:1975;117-126
23. MacIntosh L. Molecular biology of the alternative oxidase. Plant Physiol. 105:1994;781-786
24. Minagawa N., Yoshimoto A. The induction of cyanide-resistant respiration in Hansenula anomala. J Biochem. 101:1987;1141-1146
25. Matsuyama S.I., Maeda Y. Involvement of cyanide-resistant respiration in cell-type proportioning during Dictyostelium development. Dev Biol. 172:1995;182-191
26. Bienen E.J., Saric M., Pollakis G., Grady R.W., Clarkson A.B. Jr. Mitochondrial development in Trypanosoma brucei brucei transitional bloodstream forms. Mol Biochem Parasitol. 45:1991;185-192
27. Andersson S., Zomorodipour A., Andersson J., Sicheritz-Ponten T., Alsmark U., Podowski R., et al. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature. 396:1998;133-140