Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire

Journal of Clinical Investigation

Volumn 116, Issue 1, 2006, Pages 156-162

  Bonilla, Weldy V ^a,b,c   Geuking, Markus B ^a   Aichele, Peter ^a,d   Ludewig, Burkhard ^a,e   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b Prionics AG   (Switzerland)

^c Prionics AG   (Switzerland)

^d UNIVERSITY OF FREIBURG   (Germany)

^e CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CELL ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CELL SPECIFICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DONOR; IMMUNOREGULATION; MICROCHIMERISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; THYMUS; TIME;

ADOPTIVE TRANSFER; ANIMALS; CROSSES, GENETIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; ISOANTIGENS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, CYTOTOXIC; THYMECTOMY; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 31044434744     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI26565     Document Type: Article

References (45)

1. Anderson, D., Billingham, R.E., Lampkin, G.H., and Medawar, P.B. 1951. The use of skin grafting to distinguish between monocygotic and dizygotic twins in cattle. Heredity. 5:379-397.
2. Buhler, L.H., et al. 2002. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 74:1405-1409.
3. Cosimi, A.B., and Sachs, D.H. 2004. Mixed chimerism and transplantation tolerance. Transplantation. 77:943-946.
4. Ehl, S., et al. 1998. Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection. Nat. Med. 4:1015-1019.
5. Lu, L., et al. 1995. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 182:379-387.
6. Lubaroff, D.M., and Silvers, W.K. 1973. Importance of chimerism in maintaining tolerance of skin allografts in mice. J. Immunol. 111:65-71.
7. Millan, M.T., et al. 2002. Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation. 73:1386-1391.
8. Monaco, A.P. 2002. Tolerance and chimerism: separate and unequal concepts. Transplant. Proc. 34:1991-1997.
9. Starzl, T.E. 2004. Chimerism and tolerance in transplantation. Proc. Natl. Acad. Sci. U. S. A. 101(Suppl. 2):14607-14614.
10. Starzl, T.E., et al. 1992. Cell migration, chimerism, and graft acceptance. Lancet. 340:1579-1582.
11. Starzl, T.E., et al. 1993. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology. 17:1127-1152.
12. Wood, K., and Sachs, D.H. 1996. Chimerism and transplantation tolerance: cause and effect. Immunol. Today. 17:584-587; discussion 588.
13. Claas, F. 2004. Chimerism as a tool to induce clinical transplantation tolerance. Curr. Opin. Immunol. 16:578-583.
14. Elster, E.A., et al. 2004. The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials. Transpl. Immunol. 13:87-99.
15. Monaco, A.P. 2004. Prospects and strategies for clinical tolerance. Transplant. Proc. 36:227-231.
16. Wood, K.J., and Sakaguchi, S. 2003. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3:199-210.
17. Walker, L.S., and Abbas, A.K. 2002. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2:11-19.
18. Redmond, W.L., and Sherman, L.A. 2005. Peripheral tolerance of CD8 T lymphocytes. Immunity. 22:275-284.
19. Burnet, F.M. 1959. The clonal selection theory of acquired immunity. Cambridge University Press. New York, New York, USA. 209 pp.
20. Owen, R.D. 1945. Immunogenetic consequences of vascular anastomoses between bovine twins. Science. 102:400-401.
21. Billingham, R.E., Brent, L., and Medawar, P.B. 1953. Actively aquired tolerance of foreign cells. Nature. 172:603-606.
22. Weigle, W.O. 1973. Immunological unresponsiveness. Adv. Immunol. 16:61-122.
23. Billingham, R.E., and Brent, L. 1956. Acquired tolerance of foreign cells in newborn animals. Proc. R. Soc. Lond. B. Biol. Sci. 146:78-90.
24. Moskophidis, D., Lechner, F., Pircher, H., and Zinkernagel, R.M. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature. 362:758-761.
25. Critchfield, J.M., et al. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 263:1139-1143.
26. Aichele, P., Brduscha-Riem, K., Zinkernagel, R.M., Hengartner, H., and Pircher, H. 1995. T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 182:261-266.
27. Fehr, T., and Sykes, M. 2004. Tolerance induction in clinical transplantation. Transpl. Immunol. 13:117-130.
28. Ehl, S., et al. 1998. Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology. J. Exp. Med. 187:763-774.
29. Ehl, S., et al. 2000. Donor cell persistence and activation-induced unresponsiveness of peripheral CD8+ T cells. Eur. J. Immunol. 30:883-891.
30. Yano, Y., et al. 2001. Microchimeric cells from the peripheral blood associated with cardiac grafts are bone marrow derived, long-lived and maintain acquired tolerance to minor histocompatibility antigen H-Y. Transplantation. 71:1456-1462.
31. Welsh, R.M. 2001. Assessing CD8 T cell number and dysfunction in the presence of antigen. J. Exp. Med. 193:F19-F22.
32. Picca, C.C., and Caton, A.J. 2005. The role of self-peptides in the development of CD4+ CD25+ regulatory T cells. Curr. Opin. Immunol. 17:131-136.
33. Webb, S.R., and Sprent, J. 1990. Induction of neonatal tolerance to Mlsa antigens by CD8+ T cells. Science. 248:1643-1646.
34. Sterzl, J., and Silverstein, A.M. 1967. Developmental aspects of immunity. Adv. Immunol. 6:337-459.
35. Rammensee, H.G., Kroschewski, R., and Frangoulis, B. 1989. Clonal anergy induced in mature V beta 6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells. Nature. 339:541-544.
36. Ramsdell, F., and Fowlkes, B.J. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science. 257:1130-1134.
37. Schwartz, R.H. 1990. A cell culture model for T lymphocyte clonal anergy. Science. 248:1349-1356.
38. Waldmann, H., et al. 2004. Regulatory T cells and organ transplantation. Semin. Immunol. 16:119-126.
39. Fink, P.J., Shimonkevitz, R.P., and Bevan, M.J. 1988. Veto cells. Annu. Rev. Immunol. 6:115-137.
40. Walsh, P.T., Taylor, D.K., and Turka, L.A. 2004. Tregs and transplantation tolerance. J. Clin. Invest. 114:1398-1403. doi:10.1172/ JCI200423238.
41. Joffre, O., Gorsse, N., Romagnoli, P., Hudrisier, D., and van Meerwijk, J.P. 2004. Induction of antigenspecific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood. 103:4216-4221.
42. Dutko, F.J., and Oldstone, M.B. 1983. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 64:1689-1698.
43. Zinkernagel, R.M., Leist, T., Hengartner, H., and Althage, A. 1985. Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D. J. Exp. Med. 162:2125-2141.
44. Altman, J.D., et al. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
45. Maloy, K.J., et al. 2000. CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability. J. Exp. Med. 191:2159-2170.