Female's heightened immune status: Estrogen, T cells, and inducible nitric oxide synthase in the balance

Endocrinology

Volumn 147, Issue 2, 2006, Pages 659-661

  Verthelyi, Daniela ^a  

^a Center for Drug Evaluation and Review   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BACTERIAL DNA; CD3 ANTIBODY; CITRULLINE; CONCANAVALIN A; ESTROGEN; ESTROGEN RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4;

AUTOIMMUNE DISEASE; B LYMPHOCYTE; BONE DESTRUCTION; CYTOTOXICITY; DENDRITIC CELL; FEMALE; HOST RESISTANCE; HUMAN; IMMUNE STATUS; INFECTION CONTROL; INFECTION RESISTANCE; INNATE IMMUNITY; LEISHMANIA MAJOR; LISTERIA MONOCYTOGENES; LYMPHOCYTE; MACROPHAGE; NATURAL KILLER T CELL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; SHORT SURVEY; T LYMPHOCYTE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGEN-PRESENTING CELLS; ESTROGENS; FEMALE; HUMANS; IMMUNITY, NATURAL; MALE; NITRIC OXIDE SYNTHASE TYPE II; SEX FACTORS; T-LYMPHOCYTES;

EID: 30944470059     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-1469     Document Type: Short Survey

References (25)

1. Verthelyi D 2001 Sex hormones as immunomodulators in health and disease. Int Immunopharmacol 1:983-993
2. Karpuzoglu-Sahin E, Zhi-Jun Y, Lengi A, Sriranganathan N, Ansar Karpuzoglu S 2001 Effects of long term estrogen treatment on IFN-γ, IL-2 and IL-4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice. Cytokine 14:208-217
3. bintermediate dendritic cells from bone marrow precursors. J Immunol 172:1426-1436
4. Karpuzoglu E, Fenaux JB, Phillips RA, Lengi AJ, Elvinger F, Ansar Ahmed S 2006 Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-γ. Endocrinology 147:662-671
5. Bogdan C 2001 Nitric oxide and the immune response. Nat Immunol 2:907-916
6. Mattner J, Schindler H, Diefenbach A, Rollinghoff M, Gresser I, Bogdan C 2000 Regulation of type 2 nitric oxide synthase by type 1 interferons in macrophages infected with Leishmania major. Eur J Immunol 30:2257-2267
7. Ito S, Ishii KJ, Ihata A, Klinman DM 2005 Contribution of Nitric Oxide to CpG-Mediated Protection against Listeria monocytogenes. Infect Immun 73: 3803-3805
8. Abramson SB, Amin AR, Clancy RM, Attur M 2001 The role of nitric oxide in tissue destruction. Best Pract Res Clin Rheumatol 15:831-845
9. Guzik TJ, Korbut R, Adamek-Guzik T 2005 Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 54:469-487
10. Park EM, Cho S, Frys KA, Glickstein SB, Zhou P, Anrather J, Ross ME, Iadecola C 27 July 2005 Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. J Cereb Blood Flow Metab doi: 10.1038/sj.jcbfm.9600194
11. Wen Y, Yang S, Liu R, Perez E, Yi KD, Koulen P, Simpkins JW 2004 Estrogen attenuates nuclear factor-κB activation induced by transient cerebral ischemia. Brain Res 1008:147-154
12. Baker AE, Brautigam VM, Watters JJ 2004 Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor β. Endocrinology 145:5021-5032
13. Xiao X, Liu D, Zheng S, Fu J, Zhang H, Chen L 2004 Protective effect of estrogen on intestinal ischemia-reperfusion injury in pubertal rats. J Pediat Surg 39:1828-1831
14. You HJ, Kim JY, Jeong HG 2003 17β-Estradiol increases inducible nitric oxide synthase expression in macrophages. Biochem Biophys Res Commun 303:1129-1134
15. Hayashi T, Yamada K, Esaki T, Muto E, Chaudhuri G, Iguchi A 1998 Physiological Concentrations of 17β-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system. J Cardiovasc Pharmacol 31:292-298
16. Verthelyi D, Ansar Karpuzoglu S 1994 17β-Estradiol, but not 5α-dihydrotestosterone, augments antibodies to double stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice. Endocrinology 135:2615-2622
17. Gursel M, Verthelyi D, Klinman DM 2002 CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells. Eur J Immunol 32:2617-2622
18. Verthelyi D, Zeuner RA 2003 Differential signaling by CpG DNA in DCs and B cells: not just TLR9. Trends Immunol 10:519-522
19. Verthelyi D, Klinman DM 2003 Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clin Immunol 109:64-71
20. Pasare C, Medzhitov R 2003 Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033-1036
21. Verthelyi D, Klinman DM 2002 CpG ODN: safety considerations. In: Raz E, ed. Microbial DNA and immune modulation. Humana Press; 385-396
22. Anders HJ 2005 A Toll for lupus. Lupus 14:417-422
23. Baldridge JR, McGowan P, Evans JT, Cluff C, Mossman S, Johnson D, Persing D 2004 Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther 4:1129-1138
24. Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA 2004 17β-Estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood 104:1404-1410
25. Nalbandian G, Kovats S 2005 Understanding sex biases in immunity: effects of estrogen on the differentiation and function of antigen-presenting cells. Immunol Res 31:91-106