Secretion of tumor-promoting and immune suppressive cytokines by cell lines of head and neck squamous cell carcinoma

In Vivo

Volumn 20, Issue 1, 2006, Pages 45-48

  Pries, Ralph ^a   Thiel, Annette ^a   Brocks, Carsten ^a   Wollenberg, Barbara ^a,b  

^a University of Schleswig   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Cytokines; HNSCC; IL 10; IL 4; IL 6; IL 8

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8;

ARTICLE; BIOASSAY; CANCER CELL CULTURE; CARCINOGENESIS; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE RELEASE; DATA ANALYSIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IN VIVO STUDY; SQUAMOUS CELL CARCINOMA; SUPERNATANT;

EID: 30844463464     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Chin D, Boyle GM, Theile DR, Parsons PG and Coman WB: Molecular introduction to head and neck cancer (HNSCC) carcinogenesis. Br J Plast Surg 57: 595-602, 2004.
2. Whiteside TL: Immunobiology of head and neck cancer. Cancer Metastasis Rev 24: 95-105, 2005.
3. Douglas WG, Tracy E, Tan D, Yu J, Hicks WL Jr, Rigual NR, Loree TR, Wang Y and Baumann H: Development of head and neck squamous cell carcinoma is associated with altered cytokine responsiveness. Mol Cancer Res 2: 585-593, 2004.
4. Whiteside TL: Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention. Semin Cancer Biol, 2005, in press.
5. Mann EA, Spiro JD, Chen LL and Kreutzer DL: Cytokine expression by head and neck squamous cell carcinomas. Am J Surg 164: 567-573, 1992.
6. Chen Z, Malhotra PS, Thomas GR, Ondrey FG, Duffey DC, Smith CW, Enamorado I, Yeh NT, Kroog GS, Rudy S, McCullagh L, Mousa S, Quezado M, Herscher LL and Van Waes C: Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res 5: 1369-1379, 1999.
7. Woods KV, El-Naggar A, Clayman GL and Grimm EA: Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res 58: 3132-3141, 1998.
8. Eisma RJ, Spiro JD and Kreutzer DL: Vascular endothelial growth factor expression in head and neck squamous cell carcinoma. Am J Surg 174: 513-517, 1997.
9. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G and Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374: 1-20, 2003.
10. Thomas GR, Chen Z, Leukinova E, Van Waes C and Wen J: Cytokines IL-1 alpha, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon gamma. Cancer Immunol Immunother 53: 33-40, 2004.
11. Seder RA and Paul WE: Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12: 635-673, 1994.
12. Kawamata H, Nakashiro IC, Uchida D, Harada K, Yoshida H and Sato M: Possible contribution of active MMP2 to lymphnode metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines. Int J Cancer 70: 120-127, 1997.
13. Andratsche M, Chaubal S, Pauli C, Mack B, Hagedorn N and Wollenberg B: Soluble CD44v6 is not a sensitive tumor marker in patients with head and neck squamous cell cancer. Anticancer Res 25: 2821-2826, 2005.
14. Lathers DM and Young MR: Increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck. Cytokine 25: 220-228, 2004.
15. Caruso C, Lio D, Cavallone L and Franceschi C: Aging, longevity, inflammation, and cancer. Ann NY Acad Sci 1028: 1-13, 2004.
16. Hodge DR, Hurt EM and Farrar WL: The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41: 2502-2512, 2005.
17. Sauter ER, Nesbit M, Watson JC, Klein-Szanto A, Litwin S and Herlyn M: Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res 5: 775-782, 1999.
18. Smith BD, Smith GL, Carter D, Sasaki CT and Haffty BG: Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. J Clin Oncol 18: 2046-2052, 2000.
19. Bancroft CC, Chen Z, Dong G, Sunwoo JB, Yeh N, Park C and Van Waes C: Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways. Clin Cancer Res 7: 435-442, 2001.
20. Riedel F, Gotte & Bergler W, Rojas W and Hormann K: Expression of basic fibroblast growth factor protein and its down-regulation by interferons in head and neck cancer. Head Neck 22: 183-189, 2000.
21. Hartmann E, Wollenberg B, Rothenfusser S, Wagner M, Wellisch D, Mack B, Giese T, Gires O, Endres S and Hartmann G: Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 63: 6478-6487, 2003.
22. Veltri RW, Rodman SM, Maxim PE, Baseler MW and Sprinkle PM: Immune complexes, serum proteins, cell-mediated immunity, and immune regulation in patients with squamous cell carcinoma of the head and neck. Cancer 57: 2295-2308, 1986.
23. Heimdal JH, Aarstad HJ and Olofsson J: Peripheral blood T-lymphocyte and monocyte function and survival in patients with head and neck carcinoma. Laryngoscope 110: 402-407, 2000.