Formulation of rate-modulating pellets for the release of ibuprofen: An extrusion-spheronization process

Journal of Microencapsulation

Volumn 22, Issue 6, 2005, Pages 643-659

  Lutchman, D ^a   Dangor, C M ^a   Perumal, D ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Extrusion spheronization; Ibuprofen pellets; PH dependent release; Process and formulation variables; Release rate modulation

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG TARGETING; FREEZE DRYING; PARTICLE SIZE; PATIENT COMPLIANCE; PELLET EXTRUSION; PH; PHARMACEUTICAL ENGINEERING; REPRODUCIBILITY; SPHERONIZATION; STOMACH IRRITATION; ULCEROGENESIS; VISCOSITY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; DRUG STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; LACTOSE; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; VISCOSITY;

EID: 30844447948     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040500162535     Document Type: Article

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