Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor

NeuroReport

Volumn 17, Issue 2, 2006, Pages 183-187

  Chang, Seok Lee ^a   Joe, Eun Hye ^a   Jou, Ilo ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Astrocytes; Inducible nitric oxide synthase; Interferon regulatory factor 1; Interferon ; Liver X receptor; Oxysterols; Signal transducer and activator of transcription

Indexed keywords

22 HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; BETA INTERFERON; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; NITRIC OXIDE; OXYSTEROL; RETINOID X RECEPTOR; RETINOID X RECEPTOR AGONIST; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENCEPHALITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BENZOIC ACIDS; BENZYLAMINES; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTEROL; DESMOSTEROL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INTERFERON REGULATORY FACTOR-1; INTERFERON-BETA; KETOCHOLESTEROLS; LIPOPOLYSACCHARIDES; MODELS, BIOLOGICAL; NITRIC OXIDE SYNTHASE TYPE II; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES;

EID: 30744464820     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000198436.52259.40     Document Type: Article

References (24)

1. Smith LL. Cholesterol autoxidation 1981-1986. Chem Phys Lipids 1987; 44:87-125.
2. Russell DW. Oxysterol biosynthetic enzymes. Biochim Biophys Acta 2000; 1529:126-135.
3. Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142:1-28.
4. Guardiola F, Codony R, Addis PB, Rafecas M, Boatella J. Biological effects of oxysterols: current status. Food Chem Toxicol 1996; 34:193-211.
5. Schroepfer GJ Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000; 80:361-554.
6. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995; 83:841-850.
7. Peet DJ, Janowski BA, Mangelsdorf DJ. The LXRs: a new class of oxysterol receptors. Curr Opin Genet Dev 1998; 8:571-575.
8. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, et al. Role of LXRs in control of lipogenesis. Genes Dev 2000; 14:2831-2838.
9. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996; 383:728-731.
10. Russell DW. Nuclear orphan receptors control cholesterol catabolism. Cell 1999; 97:539-542.
11. Kainu T, Kononen J, Enmark E, Gustafsson JA, Pelto-Huikko M. Localization and ontogeny of the orphan receptor OR-1 in the rat brain. J Mol Neurosci 1996; 7:29-39.
12. Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, et al. Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol 2002; 16:1378-1385.
13. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 2003; 278:10443-10449.
14. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 2003; 9:213-219.
15. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci USA 2002; 99:7604-7609.
16. Park EJ, Park SY, Joe EH, Jou I. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J Biol Chem 2003; 278:14747-14752.
17. Lee JH, Park EJ, Kim OS, Kim HY, Joe EH, Jou I. Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. Glia 2005; 50:66-79.
18. Lee JH, Joe EH, Jou I. PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia. Neuroreport 2005; 16:829-833.
19. Aviram M. Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 1993; 98:1-9.
20. Dyer RG, Hetherington CS, Alberti KG, Laker MF. Simultaneous measurement of phytosterols (campesterol and beta-sitosterol) and 7-ketocholesterol in human lipoproteins by capillary column gas chromatography. J Chromatogr B Biomed Appl 1995; 663:1-7.
21. Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA 1999; 96:266-271.
22. Jacobs AT, Ignarro LJ. Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem 2001; 276:47950-47957.
23. Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 2002; 8:1243-1248.
24. Whitney KD, Watson MA, Goodwill B, Galardi CM, Maglich JM, Wilson JG, et al. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. J Biol Chem 2001; 276:43509-43515.