Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated- K+channels

Neuromuscular Disorders

Volumn 16, Issue 1, 2006, Pages 39-45

  Tricarico, Domenico ^a   Mele, Antonietta ^a   Conte Camerino, Diana ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Ca2+ activated K+channels; Carbonic anhydrase inhibitors; Hypokalaemic periodic paralysis; Skeletal muscle

Indexed keywords

ACETAZOLAMIDE; BENDROFLUMETHIAZIDE; CALCIUM CHANNEL; CARBONATE DEHYDRATASE INHIBITOR; DICLOFENAMIDE; ELECTROLYTE; ETHOXZOLAMIDE; HYDROCHLOROTHIAZIDE; INSULIN; METHAZOLAMIDE; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; EX VIVO STUDY; HYPOKALEMIA; IN VIVO STUDY; INSULIN RESPONSE; MALE; NONHUMAN; PARALYSIS; PATCH CLAMP; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CARBONIC ANHYDRASE INHIBITORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; HYPOKALEMIC PERIODIC PARALYSIS; MALE; MEMBRANE POTENTIALS; MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM DEFICIENCY; RATS; RATS, WISTAR; SPECTROPHOTOMETRY;

EID: 30644474721     PISSN: 09608966     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nmd.2005.10.005     Document Type: Article

References (22)

1. S. Lindskog Structure and mechanism of carbonic anhydrase Pharmacol Ther 74 1997 1 20
2. P. Wetzel, and G. Gros Carbonic anhydrases in striated muscle W.R. Chegwdden N.D. Carter Y.H. Edwards The carbonic anhydrases: New Horizons 2002
3. D.G. Brater Pharmacology of diuretics Am J Med Sci 319 2000 38 50
4. A. Greenberg Diuretic complications Am J Med Sci 319 2000 10 24
5. N. Gordon Episodic ataxia and channelopathies Brain Dev 20 1998 9 13
6. F. Kubota, A. Kifune, and N. Shibata Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiograph study Epilepsy Res 33 1999 93 97
7. S. Battistini, S. Stenirri, and M. Piatti A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia Neurology 53 1999 38 43
8. F. Lehmann-Horn, and K. Jurkat-Rott Voltage-gated ion channels and hereditary disease Physiol Rev 79 1999 1317 1372
9. F. Lehmann-Horn, and R. Rüdel Molecular pathophysiology of voltage-gated ion channels Rev Physiol Biochem Pharmacol 128 1996 195 268
10. L. Ptacek The familial periodic paralyses and nondystrophic myotonias Am J Med 104 1998 58 70
11. S.C. Cannon An expanding view for the molecular basis of familial periodic paralysis Neuromuscul Disord 12 2002 533 543
12. T.P. Links, M.J. Zwarts, and H.J.H. Oosterhuis Improvement of muscle strength in familial hypokalemic periodic paralyses with acetazolamide J Neurol Neurosurg Psychiatry 51 1988 1142 1145
13. J. Junker, W. Haverkamp, E. Schulze-Bahr, L. Eckardt, W. Paulus, and R. Kiefer Amiodarone and acetazolamide for the treatment of genetically confirmed severe Andersen syndrome Neurology 59 2002 466
14. + channel mutations causing hypokalaemic periodic paralysis type II Brain 125 2002 835 843
15. D. Tricarico, M. Barbieri, and D. Conte Camerino Acetazolamide opens the muscular K ca 2 + channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis Ann Neurol 48 2000 304 312
16. + depleted rat, an animal model of hypokalemic periodic paralysis Mol Pharmacol 54 1998 197 206
17. + channels in patients with hypokalemic periodic paralysis J Clin Invest 103 5 1999 675 682
18. D. Tricarico, R. Petruzzi, and D. Conte Camerino Changes of the biophysical properties of calcium-activated potassium channels of rat skeletal muscle fibres during aging Pflügers Arch 434 1997 822 829
19. D. Tricarico, R. Capriulo, and D. Conte Camerino Involvement of K ca 2 + channels in the local abnormalities and hyperkalemia following the ischemia-reperfusion injury of rat skeletal muscle Neuromuscul Disord 12 2002 258 265
20. Tricarico D, Mele A, Conte Camerino D. Phenotype-dependent functional and pharmacological properties of Bk channels in skeletal muscle: effects of microgravity. Neurobiol Dis 2005;20:296-302.
21. +-deficient rats Fed Am Soc Exp Biol J 18 2004 760 761
22. P. Wetzel, and G. Gros Inhibition and kinetic properties of membrane-bound carbonic anhydrases in rabbit skeletal muscles Arch Biochem Biophys 356 1998 151 158