Expression of hepatitis C virus core protein in hepatocytes does not modulate proliferation or apoptosis of CD8+ T cells

Yonsei Medical Journal

Volumn 46, Issue 6, 2005, Pages 827-834

  Jin, Young Hee ^a   Crispe, I Nicholas ^a   Park, Sun ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Baculoviridae; Co culture techniques; Cytotoxic; Hepacivirus; T cells; Viral core proteins

Indexed keywords

CD8 ANTIGEN; CORE PROTEIN; VIRUS VECTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; BACULOVIRUS; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; GENETIC TRANSDUCTION; HEPATITIS C VIRUS; IMMUNE DEFICIENCY; IMMUNOMODULATION; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE;

EID: 30644468477     PISSN: 05135796     EISSN: 05135796     Source Type: Journal    
DOI: 10.3349/ymj.2005.46.6.827     Document Type: Article

References (34)

1. Mattsson L, Sonnerborg A, Weiland O. Outcome of acute symptomatic non-A, non-B hepatitis: a 13-year follow-up study of hepatitis C virus markers. Liver 1993;13:274-8.
2. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur J Immunol 2000; 30:2479-87.
3. Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RI, Dohrenwend P, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-512.
4. Cooper S, Erickson AL, Adams EJ, Kansopon J, Weiner AJ, Chien DY, et al. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10: 439-49.
5. Simmonds P. Viral heterogeneity of the hepatitis C virus. J Hepatol 1999;31 SuppI 1:54-60.
6. Yeh BI, Kim HW, Kim HS, Lee JY, Lee KH, Lee KM, et al. The prediction of interferon-alpha therapeutic effect by sequence variation of the HCV hypervariable region 1. Yonsei Med J 1999;40:430-8.
7. Large MK, Kittlesen DJ, Hahn YS. Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. J Immunol 1999;162:931-8.
8. Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, Braciale TJ, Hahn YS. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest 2000;106:1239-49.
9. Eisen-Vandervelde AL, Waggoner SN, Yao ZQ, Cale EM, Hahn CS, Hahn YS. Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation. J. Biol Cbem 2004;279:43479-86.
10. + T cells leads to impaired activation of Lek and Akt. J Virol 2004; 78:6409-19.
11. + T cell differentiation in acute hepatitis C virus infection: the role of the virus. Eur J Immunol 2004;34: 438-46.
12. Soguero C, Joo M, Chianese-Bullock KA, Nguyen DT, Tung K, Hahn YS. Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J Virol 2002;76:9345-54.
13. Liu ZX, Nishida H, He JW, Lai MM, Feng N, Dennert G. Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity. J Virol 2002;76:990-7.
14. Sun J, Bodola F, Fan X, Irshad H, Soong L, Lemon SM, et al. Hepatitis C virus core and envelope proteins do not suppress the host's ability to clear a hepatic viral infection. J Virol 2001;75:11992-8.
15. Hofmann C, Sandig V, Jennings G, Rudolph M, Schlag P, Strauss M. Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc Natl Acad Sci U S A 1995;92:10099-103.
16. Condreay JP, Witherspoon SM, Clay WC, Kest TA. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. Proc Natl Acad Sci USA 1999;96:127-32.
17. Nagelkerke JF, Barto KP, van Berkel TJ. In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem 1983;258:12221-7.
18. Knolle PA, Germann T, Treichel U, Uhrig A, Schmitt E, Hegenbarth S, et al. Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. J Immunol 1999;162:1401-7.
19. Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 1997;6:715-26.
20. Hogquist KA, Jameson, SC Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 1994;76:17-27.
21. Nuti S, Rosa D, Valiante NM, Saletti G, Caratozzolo M, Dellabona P, et al. Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Va24+ T cells and rapid elimination of effector cells by apoptosis. Eur J Immunol 1998; 28:3448-55.
22. Emi K, Nakamura K, Yuh K, Sugyo S, Shijo H, Kuroki M, et al. Magnitude of activity in chronic hepatitis C is influenced by apoptosis of T cells responsible for hepatitis C virus. J Gastroenterol Hepatol 1999;14:1018-24.
23. Huang L, Soldevila G, Leeker M, Flavell R, Crispe IN. The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1994;1:741-9.
24. Betz GT, Altman JD, Doherty PC. Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia. Proc Natl Acad Sci USA 1998;95:13812-7.
25. Hahn CS, Cho YG, Kang BS, Lester IM, Hahn YS. The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human lymphoblastoid T cell line. Virology 2000;276:127-37.
26. Moorman JP, Prayther D, McVay D, Hahn YS, Hahn CS. The C-terminal region of hepatitis C core protein is required for Fas-ligand independent apoptosis in Jurkat cells by facilitating Fas oligomerization. Virology 2003;312:320-9.
27. Sarobe P, Lasarte JJ, Casares N, Lopez-Diaz de Cerio A, Baixeras E, Labarga P, et al. Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins. J Virol 2002;76:5062-70.
28. Lee CH, Choi YH, Yang SH, Lee CW, Ha SJ, Sung YC. Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages. Virology 2001;279:271-9.
29. Nakamoto Y, Kaneko S, and Kobayashi K. Monocyte-dependent cell death of T lymphocyte subsets in chronic hepatitis C. Immunol Lett 2001;78:169-74.
30. Crispe IN, Dao T, Klugewitz K, Mehal WZ, Metz DP. The liver as a site of T-cell apoptosis: graveyard, or killing field? Immunol Rev 2000;174:47-62.
31. Mehal WZ, Azzaroli F, Crispe IN. Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J Immunol 2001; 167:667-73.
32. Qian S, Wang Z, Lee Y, Chiang Y, Bonham C, Fung J, et al. Hepatocyte-induced apoptosis of activated T cells, a mechanism of liver transplant tolerance, is related to the expression of ICAM-1 and hepatic lectin. Transplant Proc 2001;33:226.
33. Jin Y, Fuller L, Carreno M, Zucker K, Roth D, Esquenazi V, et al. The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage. J Clin Immunol 1997;17:140-53.
34. Horiike N, Onji M, Kumon I, Kanaoka M, Michitaka K, Ohta Y. Intercellular adhesion molecule-1 expression on the hepatocyte membrane of patients with chronic hepatitis B and C. Liver 1993;13:10-4.