Synthesis and antimicrobial activities of some new nitroimidazole derivatives

Archives of Pharmacal Research

Volumn 26, Issue 10, 2003, Pages 773-777

  Benkli, Kadriye ^a   Karaburun, Ahmet Çaǧri ^a   Gündoǧdu Karaburun, Nalan ^a   Demirayak, Şeref ^a   Güven, Kiymet ^a  

^a ANADOLU UNIVERSITY   (Turkey)

Author keywords

Antibacterial and antifungal activity; Metronidazole; Nitroimidazoles

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; METRONIDAZOLE; NITROIMIDAZOLE DERIVATIVE;

ARTICLE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFRARED RADIATION; MASS SPECTROMETRY; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; FUNGI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; INFRARED RAYS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; NITROIMIDAZOLES;

EID: 30544454106     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02980019     Document Type: Article

References (19)

1. Allimony, H. A., Saad, H. A., and Mariah, F. A. A., Synthesis and antimicrobial activity of some nitrogen heterobicyclic systems: Part I. Indian J. Chem. Sec. B, 38, 445-451 (1999).
2. Bowden, K. and Izadi, J., Multifunctional derivatives of metronidazole. Farmaco, 53, 58-61(1998).
3. Carganico, G. and Cozzi, P., Imidazolyl derivatives in medicinal chemistry. Farmaco, 46, 209-231 (1991).
4. Cawper, R. N. and Davidson, L. H., α-Bromo acetophenone. Org. Syn. Coll., 2, 480 (1943).
5. Demirayak, Ş. and Kiraz, N., Some nitroimidazole derivatives as possible antibacterial agents. Farmaco, 48, 443-446 (1993).
6. Demirayak, Ş., Karaburun, A. Ç., and Kiraz, N., Synthesis and antibacterial activities of some 1-[2-(substituted pyrrol-1-yl)ethyl]-2- methyl-5-nitroimidazole derivatives. Eur. J. Med. Chem., 34, 275-278 (1999).
7. Finegold, S. M., Martin, W. J., and Scott E. G., Bailey and Scotts Diagnostic Microbiology; The C.V. Mosby Company, Saint Louis (1978).
8. Griffin, S., Woods, T. S., and Klayman, D. L., Thioureas in the synthesis of heterocycles. Adv. Heterocyclic Chem., 18, 99-158 (1974).
9. Hanna, M. M., Abbas, SE-S., Mogahazy Aly, S. M., Megid, R. M. A., and Moustafa, M. M., Synthesis and antimicrobial activity of some substituted 3-aryl-5-benzylidene-2-phenyl-4-imidazolone derivatives. Bull. Fac. Pharm. Cairo Univ., 32, 353-358 (1994).
10. Lima, M. C. A., Costa, D. L. B., Goes, A. J. S., Galdino, S. L., Pitta, I. R., and Luu-Duc, C., Synthèse et activité antimicrobienne de dérivès chlorobenzyl benzylidène imidazolidinediones et thiazolidinediones substituées. Pharmazie, 47, 182-184 (1992).
11. Mahfouz, N. M. and Hasan, M. A., Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility. J. Pharm. Pharmacol., 53, 841-848 (2001).
12. Mahfouz, N. M., Aboul-Fadl, T., and Diab, A. K., Metronidazole twin ester prodrugs; synthesis, physicochemical properties, hydrolysis kinetics and antigiardial activity. Eur. J. Med. Chem., 33, 675-683 (1998).
13. Mc Ginnis, M. R. and Rinaldi. M. G., Antifungal drugs; Mechanism of action, drug resistance, susceptibility testing and assays of activity in biological fluids, Ed. V. Lorian, Antibiotics in Laboratory Medicine Third Ed., Williams and Wilkins, London, Los Angeles, 198 (1991).
14. Patel, P. H., Korgaokar, S. S., and Parekh, H. H., Synthesis and antimicrobial activity of 4-thiazolidinone and imidazolinone derivatives bearing a 2-aminothiazole moiety. Indian J. Heterocycl. Chem., 7, 73-76 (1997).
15. Silverstein, R. M., Bassler, G. C., and Morrill, T. C., Spectrometric identification of organic compounds, 5th ed., John Wiley and Sons (1991).
16. Tovarna Zdravil, K. R. K. A., 1-(2-Bromoethyl)-2-methyl-5-nitroimidazole from the 1-(2-hydroxyethyl) analog, Fr. 1,540,545, C.A. 71, 81362k (1969).
17. Turan-Zitouni, G., SIvacI, D. M., KaplancIklI, Z. A., and Özdemir, A., Synthesis and antimicrobial activity of some pyridinyliminothiazoline derivatives. Farmaco, 57, 569-572 (2002).
18. Turcki, I. J., Oxazoles, The Chemistry of heterocyclic compounds, Weisberger, A., Taylor, E.C., John Wiley and Sons (1986).
19. Wolf, M. E., Burgers Medicinal Chemistry and Drug Discovery, 5th ed., John Wiley and Sons, New York, Vol. 4, pp 429-452 (1997). S