Metronidazole twin ester prodrugs: Synthesis, physicochemical properties, hydrolysis kinetics and antigiardial activity

European Journal of Medicinal Chemistry

Volumn 33, Issue 9, 1998, Pages 675-683

  Mahfouz, Nadia M ^a   Aboul Fadl, Tarek ^a   Diab, Ahmed K ^b  

^a Assiut University   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

Author keywords

Antigiardial activity; Hydrolysis kinetics; Identical twin prodrugs; In vivo evaluation; Lipophilicity; Metronidazole

Indexed keywords

ESTER DERIVATIVE; METRONIDAZOLE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; ESTERIFICATION; GIARDIA MURIS; IN VIVO STUDY; LIPOPHILICITY; MOUSE; NONHUMAN; PH; PHYSICAL CHEMISTRY; RABBIT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0032446580     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80026-3     Document Type: Article

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