Multifunctional derivatives of metronidazole

Farmaco

Volumn 53, Issue 1, 1998, Pages 58-61

  Bowden, Keith ^a   Izadi, Jamshid ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Metronidazole; Nitroimidazoles

Indexed keywords

ACRYLIC ACID DERIVATIVE; ALKYL GROUP; DRUG DERIVATIVE; ESTER DERIVATIVE; IMIDAZOLE DERIVATIVE; METRONIDAZOLE; NITROIMIDAZOLE DERIVATIVE; PHTHALIC ACID ESTER; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY;

EID: 0345369589     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(97)00007-4     Document Type: Article

References (20)

1. [1] S.W. Kim, R.V. Peterson, J. Feijen, Polymeric drug delivery systems, Drug Design 10 (1980) 193.
2. [2] C.M. Samour, in: L.G. Donaruma, O. Vogl (Eds.), Polymeric Drugs, Academic Press, New York, 1978, p. 161.
3. [3] E.J. Baines, Metronidazole: its past, present and future, J. Antimicrob. Chemother. 4 (Suppl. C) (1978) 97.
4. [4] C. Cosar, C. Crissan, R. Horclois, R.M. Jacob, J. Robert, S. Tchelitcheff, R. Vaupré, Nitroimidazoles, Arzneium.-Forsch. 16 (1966) 23.
5. [5] M.J. Cho, R.R. Kurtz, C. Lewis, S.M. Machkovech, D.J. Houser, Metronidazole phosphate - a water-soluble prodrug for parenteral solutions of metronidazole, J. Pharm. Sci. 71 (1982) 410.
6. [6] H. Bundgaard, C. Larsen, P. Thorbek, Prodrugs as drug delivery systems. XXVI. Preparation and enzymic hydrolysis of various water-soluble amino acid esters of metronidazole. Int. J. Pharm. 18 (1984) 67.
7. [7] H. Bundgaard, C. Larsen, E. Arnold, Prodrugs as drug delivery systems. XXVII. Chemical stability and bioavailability of a water-soluble prodrug of metronidazole for parenteral adminstration. Int. J. Pharm. 18 (1984) 79.
8. [8] K. Bowden, J. Izadi, Prodrugs. Part 2. Acylbenzoate esters of metronidazole, Eur. J. Med. Chem. 32 (1997) in press.
9. [9] C.J. Blankley, F.J. Sauter, H.O. House, Crotyl diazoacetate, Org. Syn. Coll. 5 (1973) 258.
10. [10] O. Mitsunoba, The use of diethyl azodicarboxylate and triphenyl-phosphine in synthesis and transformation of natural products. Synthesis. (1981) 1.
11. [11] W.C. Still, M. Kahn, A. Mitra, Rapid chromatographic technique for preparative separations with moderate resolution, J. Org. Chem. 43 (1978) 2923.
12. [12] K. Holmberg, B. Hansen, Ester synthesis with dicyclohexylcarbodiimide improved by acid catalysts, Acta Chem. Scand. B 33 (1979) 410.
13. [13] Lilly Industries Ltd., Fr. Demande 2 015 181 (24 Apr. 1970), Anti-parasitic imidazoles (Chem. Abstr. 74 (1971) 53790s).
14. [14] V. Sunjic, T. Fajoliga, N. Blazevic, F. Kajfez, 1, 1′-Bis(2-methyl-4(5)-nitroimidazoles), Acta Pharm. Jugoslav. 19 (1969) 65 (Chem. Abstr. 72 (1970) 66866e).
15. [14] V. Sunjic, T. Fajoliga, N. Blazevic, F. Kajfez, 1, 1′-Bis(2-methyl-4(5)-nitroimidazoles), Acta Pharm. Jugoslav. 19 (1969) 65 (Chem. Abstr. 72 (1970) 66866e).
16. [15] E. Winkelmann, W. Raether, U. Gebert, A. Sinharay. Chemotherapeutically active nitro compounds. 4. 5-Nitroimidazoles. Part 1, Arzneim. Forsch. 27 (1977) 2251.
17. [16] Z. Zhang, M. Yen, X. Lei, Studies on chemotherapy of filariasis. II. Synthesis of 5-nitroimidazole derivatives, Yaoxue Xuehao 16 (1981) 548 (Chem. Abstr. 97 (1982) 72290v).
18. [16] Z. Zhang, M. Yen, X. Lei, Studies on chemotherapy of filariasis. II. Synthesis of 5-nitroimidazole derivatives, Yaoxue Xuehao 16 (1981) 548 (Chem. Abstr. 97 (1982) 72290v).
19. [17] D.I. Edwards, Nitroimidazole drugs-action and resistance mechanisms. II. Mechanisms of resistance, J. Antimicrob. Chemother. 31 (1993) 9.
20. [18] M.J. Ashton, personal communication.