Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants?

Anesthesiology

Volumn 86, Issue 3, 1997, Pages 567-575

  Fisher, Dennis M ^a,b   Wright, Peter M C ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

Modeling: pharmacodynamics; NONMEM; Neuromuscular relaxants: vecuronium; Pharmacodynamics: adductor pollicis; larynx; models

Indexed keywords

DRUG METABOLITE; VECURONIUM; VECURONIUM DERIVATIVE;

ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; HAND MUSCLE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; LARYNX MUSCLE; MUSCLE RELAXATION; MUSCLE TWITCH; NEUROMUSCULAR BLOCKING; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030894412     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199703000-00008     Document Type: Article

References (14)

1. Verotta D, Sheiner LB: Semiparametric analysis of non-steady-state pharmacodynamic data. J Pharmacokinet Biopharm 1991; 19:691-712
2. Bragg P, Fisher DM, Shi J, Donati F, Meistelman C, Lau M, Sheiner LB: Comparison of twitch depression of the adductor pollicis and the respiratory muscles. Pharmacodynamic modeling without plasma concentrations. ANESTHESIOLOGY 1994; 80:310-9
3. Fisher DM, Szenohradszky J, Wright PMC, Lau M, Brown R, Sharma M: Pharmacodynamic modeling of vecuronium-induced twitch depression: Rapid plasma-to-effect site equilibration explains faster onset at resistant laryngeal muscles than at the adductor pollicis. ANESTHESIOLOGY 1997; 86:558-66
4. Donati F, Plaud B, Meistelman C: A method to measure elicited contraction of laryngeal adductor muscles during anesthesia. ANESTHESIOLOGY 1991; 74:827-32
5. Caldwell JE, Szenohradszky J, Segredo V, Wright PM, McLoughlin C, Sharma ML, Gruenke LD, Fisher DM, Miller RD: The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. J Pharmacol Exp Ther 1994; 270:1216-22
6. Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J: Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979; 25:358-71
7. Ducharme J, Varin F, Bevan DR, Donati F: Importance of early blood sampling on vecuronium pharmacokinetic and pharmacodynamic parameters. Clin Pharmacokinet 1993; 24:507-18
8. Unadkat JD, Bartha F, Sheiner LB: Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther 1986; 40:86-93
9. Verotta D, Sheiner L: Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm. Comput Appl Biosci 1987; 3:345-9
10. Wright PMC, Hart P, Lau M, Sharma ML, Gruenke L, Fisher DM: Cumulative characteristics of atracurium and vecuronium. A simultaneous clinical and pharmacokinetic study. ANESTHESIOLOGY 1994; 81:59-68
11. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD: Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med 1992; 327;524-8
12. Cannon JE, Fahey MR, Castagnoli KP, Furuta T, Canfell PC, Sharma M, Miller RD: Continuous infusion of vecuronium: The effect of anesthetic agents. ANESTHESIOLOGY 1987; 67:503-6
13. Hart PS, McCarthy GJ, Brown R, Lau M, Fisher DM: The effect of plasma cholinesterase activity on mivacurium infusion rates. Anesth Analg 1995; 80:760-3
14. Donati F, Meistelman C, Plaud B: Vecuronium neuromuscular blockade at the adductor muscles of the larynx and adductor pollicis. ANESTHESIOLOGY 1991; 74:833-7