Therapeutic effects of progestins, androgens, and tibolone for menopausal symptoms

American Journal of Medicine

Volumn 118, Issue 12 SUPPL. 2, 2005, Pages 88-92

  Liu, James H ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Androgen; Menopausal symptoms; Progestin; Tibolone

Indexed keywords

ANDROGEN; ESTRATEST; ESTROGEN; GESTAGEN; NORETHISTERONE ACETATE; PRASTERONE; PROGESTERONE; TESTOSTERONE; TIBOLONE;

BONE DENSITY; CLINICAL TRIAL; COGNITION; CONFERENCE PAPER; FEMALE SEXUAL DYSFUNCTION; FLUID RETENTION; HUMAN; MASTALGIA; MENOPAUSAL SYNDROME; PRIORITY JOURNAL; SEXUAL AROUSAL; SIDE EFFECT; VAGINA DISCHARGE; VASOMOTOR DISORDER; WEIGHT GAIN; XEROSTOMIA;

EID: 30544439010     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2005.09.040     Document Type: Conference Paper

References (38)

1. G. Bertelli, M. Venturini, L. Mastro Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients a randomized study Ann Oncol. 13 2002 883 888
2. S.K. Quella, C. Loprinzi, J. Sloan Long term use of megestrol acetate by cancer survivors for the treatment of hot flashes Cancer 82 1998 1784 1788
3. S.M. Paul, R.H. Purdy Neuroactive steroids FASEB J 6 1992 2311 2322
4. E.S. Surrey, H.L. Judd Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis a prospective randomized trial J Clin Endocrinol Metab 75 1992 558 563
5. B.J. Riis, C. Christiansen, J.S. Johansen, J. Jacobson Is it possible to prevent bone loss in young women treated with luteinizing hormone-releasing hormone agonists? J Clin Endocrinol Metab 70 1990 920 924
6. G.A. Laughlin, E. Barrett-Connor Sexual dimorphism in the influence of advancing aging on adrenal hormone levels the Rancho Bernardo study J Clin Endocrinol Metab 85 2000 3561 3568
7. C.H. Liu, G.A. Laughlin, U.G. Fischer, S.S.C. Yen Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women evidence for a reduced 17,20 desmolase enzymatic activity J Clin Endocrinol Metab 71 1990 900 906
8. J.F. Mortola, S.S.C. Yen The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women J Clin Endocrinol Metab 71 1990 696 704
9. A.J. Morales, J.J. Nolan, J.C. Nelson, S.S.C. Yen Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age J Clin Endocrinol Metab 78 1994 1360 1367
10. A.D. Genazzani, M. Stomati, F. Bernardi, M. Pieri, L. Rovati, A.R. Genazzani Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids Fertil Steril 80 2003 1495 1501
11. A. Lasco, N. Frisina, N. Morabito Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women Eur J Endocrinol 145 2001 457 461
12. L. Hackbert, J.R. Heiman Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women J Womens Health Gend Based Med 11 2002 155 161
13. F. Labrie, P. Diamond, L. Cusan, J.L. Gomez, A. Belanger, B. Candas Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women J Clin Endocrinol Metab 82 1997 3498 3505
14. E. Hirshman, P. Merritt, C.C.L. Wang Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women Horm Behav 45 2004 144 155
15. C. Longcope, C. Franz, C. Morello, R. Baker, C.C. Johnson Steroid and gonadotropin levels in women during the peri-menopausal years Maturitas 8 1986 189 196
16. H.L. Judd, G.E. Judd, W.E. Lucas, S.S.C. Yen Endocrine function of the postmenopausal ovary concentration of androgens and estrogens in ovarian and peripheral vein blood J Clin Endocrinol Metab 39 1974 1020 1024
17. J.A. Simon, E. Klaiber, B. Wiita, A. Bowen, H.M. Yang Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women Menopause 6 1999 138 146
18. B.B. Sherwin, M.M. Gelfand Effects of parenteral administration of estrogen and androgen on plasma hormone levels and hot flashes in the surgical menopause Am J Obstet Gynecol 148 1984 552 557
19. B.B. Sherwin, M.M. Gelfand Differential symptom response to parenteral estrogen and/or androgen administration in surgical menopause Am J Obstet Gynecol 151 1985 153 158
20. B.B. Sherwin, M.M. Gelfand Sex steroids and affect in the surgical menopause a double-blind, crossover study Psychoneuroendocrinology 10 1985 325 335
21. B.B. Sherwin Affective changes with estrogen and androgen replacement therapy in surgically menopausal women J Affect Disord 14 1988 177 187
22. E. Barrett-Connor, R. Young, M. Notelovitz A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women J Reprod Med 44 1999 1012 1020
23. J. Shifren, G. Braunstein, J. Simon Transdermal testosterone treatment in women with impaired sexual function after oophorectomy N Engl J Med 343 2000 682 688
24. S. Kingsberg, J. Buster, K. Wekselman Two phase III studies demonstrate testosterone transdermal patch improves sexual activity and sexual desire in surgically menopausal women. 2004 Presented at the European Society for Sexual Medicine; December 6; London, England.
25. R. Kroll, S. Davis, M. Moreau, A. Waldbaum, J. Shifren, K. Wekselman Testosterone transdermal patch (TTP) significantly improved sexual function in naturally menopausal women in a large phase III study [abstract] Fertil Steril 82 2004 0 192
26. J.A. Simon, S.R. Davis, N.B. Watts, V.P. Eymer, J.D. Lucas, G.D. Braunstein Safety and tolerability of transdermal testosterone therapy versus placebo in surgically menopausal women receiving oral or transdermal estrogen [abstract] Menopause 9 2002 P-87
27. K. Modelska, S. Cummings Tibolone for postmenopausal women systematic review of randomized trials J Clin Endocrinol Metab 87 2002 16 23
28. M.B. Landgren, H.J. Bennink, F.A. Helmond, S. Engelen Dose-response analysis of effects of tibolone on climacteric symptoms BJOG 109 2002 1109 1114
29. A.R. Genazzani, F. Petraglia, F. Facchinetti Effects of Org OD 14 on pituitary and peripheral β-endorphin in castrated rats and post-menopausal women Maturitas 1 suppl 1987 35 48
30. J. Nathorst-Boos, M. Hammar Effect on sexual life - a comparison between tibolone and a continuous estradiol-norethisterone acetate regimen Maturitas 26 1997 15 20
31. M. Doren, A. Ruebig, W. Holzgreve Differential effects on the androgen status of postmenopausal women treated with tibolone and continuous combined estradiol and norethindrone acetate replacement therapy Fertil Steril 75 2001 554 558
32. M. Hammar, J. Christau, T. Rud, K. Garre A double-blind, randomized trial comparing the effects of tibolone and continuous combined hormone replacement therapy in postmenopausal women with menopausal symptoms Br J Obstet Gynaecol 105 1998 904 911
33. J. Gallagher, D.J. Baylink, M. McClung Prevention of bone loss with tibolone in postmenopausal women results of two randomized, double-blind, placebo-controlled, dose-finding studies J Clin Endocrinol Metab 86 2001 4717 4726
34. B. Berning, J.W. van Kuijk, B.C. Fauser Absent correlation between vaginal bleeding and oestradiol levels or endometrial morphology during tibolone use in early postmenopausal women Maturitas 35 2000 81 88
35. J. Huber, S. Palacios, L. Berglund Effects of tibolone and continuous combined hormone replacement therapy on bleeding rates, quality of life and tolerability in postmenopausal women BJOG 109 2002 886 893
36. I. Valdivia, I. Campodonico, A. Tapia, M. Capetillo, A. Espinoza, P. Lavin Effects of tibolone and continuous combined hormone therapy on mammographic breast density and breast histochemical markers in postmenopausal women Fertil Steril 81 2004 617 623
37. E. Lundstrom, A. Christow, W. Kersemaekers Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density Am J Obstet Gynecol 186 2002 717 722
38. N. Bjarnason, K.H. Bjarnason, H.J. Bennink, C. Christiansen Tibolone influence on markers of cardiovascular disease J Clin Endocrinol Metab 82 1997 1752 1756