Differentiation of human adult CD34+ stem cells into cells with a neural phenotype: Role of astrocytes

Experimental Neurology

Volumn 197, Issue 2, 2006, Pages 399-406

  Reali, Camilla ^a   Scintu, Franca ^a   Pillai, Rita ^a   Cabras, Stefano ^a   Argiolu, Francesca ^a   Ristaldi, Maria Serafina ^b   Sanna, Maria Adele ^c   Badiali, Manuela ^c   Sogos, Valeria ^a,d  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

^c Osp Regionale per le Microcitemie   (Italy)

^d Cittadella Universitaria ^*  (Italy)

Author keywords

Differentiation; Hematopoietic stem cells; Human astrocyte; Neural cells

Indexed keywords

CD34 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; NESTIN; NEURON SPECIFIC ENOLASE; POLYLYSINE;

ADOLESCENT; ADULT; ARTICLE; ASTROCYTE; CD34 SELECTION; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STRUCTURE; CHILD; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NERVE CELL; NEUROFILAMENT; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD34; ASTROCYTES; BLOTTING, WESTERN; BRAIN; CELL COUNT; CELL DIFFERENTIATION; CELL SIZE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FETUS; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; NERVE TISSUE PROTEINS; NEURONS; PHENOTYPE; POLYLYSINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS;

EID: 30444452372     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.10.004     Document Type: Article

References (48)

1. T.R. Brazelton, F.M. Rossi, G.I. Keshet, and H.M. Blau From marrow to brain: expression of neuronal phenotypes in adult mice Science 290 2000 1775 1779
2. M.Y. Chang, H. Son, Y.S. Lee, and S.H. Lee Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively Mol. Cell. Neurosci. 23 2003 414 426
3. J. Chen, Y. Li, L. Wang, M. Lu, X. Zhang, and M. Chopp Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats J. Neurol. Sci. 189 2001 49 57
4. P. Chomczynski A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples BioTechniques 15 1993 532 537
5. M. Chopp, X.H. Zhang, Y. Li, L. Wang, J. Chen, D. Lu, M. Lu, and M. Rosenblum Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation NeuroReport 11 2000 3001 3005
6. C.R. Cogle, A.T. Yachnis, E.D. Laywell, D.S. Zander, J.R. Wingard, D.A. Steindler, and E.W. Scott Bone marrow transdifferentiation in brain after transplantation: a retrospective study Lancet 363 2004 1432 1437
7. M.G. Ennas, D. Cocchia, E. Silvetti, V. Sogos, A. Riva, S. Torelli, and F. Gremo Immunocompetent cell markers in human fetal astrocytes and neurons in culture J. Neurosci. Res. 32 1992 424 436
8. G. Ferrari, G. Cusella-DeAngelis, M. Coletta, E. Paolucci, A. Stornaiuolo, G. Cossu, and F. Mavilio Muscle regeneration by bone marrow-derived myogenic precursors Science 279 1998 1528 1530
9. A.D. Garcia, N.B. Doan, T. Imura, T.G. Bush, and M.V. Sofroniew GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain Nat. Neurosci. 7 2004 1233 1241
10. D.H. Geschwind, J. Ou, M.C. Easterday, J.D. Dougherty, R.L. Jackson, Z. Chen, H. Antoine, A. Terskikh, I.L. Weissman, S.F. Nelson, and H.I. Kornblum A genetic analysis of neural progenitor differentiation Neuron 29 2001 325 339
11. + hematopoietic stem cells Ann. N. Y. Acad. Sci. 996 2003 141 151
12. H.N. Hao, J. Zhao, R.L. Thomas, G.C. Parker, and W.D. Lyman Fetal human hematopoietic stem cells can differentiate sequentially into neural stem cells and then astrocytes in vitro J. Hematother. Stem Cell Res. 12 2003 23 32
13. P.G. Haydon GLIA: listening and talking to the synapse Nat. Rev., Neurosci. 2 2001 185 193
14. A. Hermann, R. Gastl, S. Liebau, M.O. Popa, J. Fiedler, B.O. Boehm, M. Maisel, H. Lerche, J. Schwarz, R. Brenner, and A. Storch Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells J. Cell Sci. 117 2004 4411 4422
15. A. Joannides, P. Gaughwin, M. Scott, S. Watt, A. Compston, and S. Chandran Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells J. Hematother. Stem Cell Res. 12 2003 681 688
16. A. Joannides, P. Gaughwin, C. Schwiening, H. Majed, J. Sterling, A. Compston, and S. Chandran Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells Lancet 364 2004 172 178
17. E.R. Kandel, J.H. Schwartz, and T.M. Jessel Principle of Neural Science 2000 McGraw-Hill Press New York
18. S. Koshizuka, S. Okada, A. Okawa, M. Koda, M. Murasawa, M. Hashimoto, T. Kamada, K. Yoshinaga, M. Murakami, H. Moriya, and M. Yamazaki Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice J. Neuropathol. Exp. Neurol. 63 2004 64 72
19. D.S. Krause, M.J. Fackler, C.I. Civin, and W.S. May CD34: structure, biology, and clinical utility Blood 87 1996 1 13
20. M. Kucia, J. Ratajczak, R. Reca, A. Janowska-Wieczorek, and M.Z. Ratajczak Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury Blood Cells Mol. Dis. 32 2004 52 57
21. P. Lang, T. Klingebiel, P. Bader, J. Greil, M. Schumm, P.G. Schlegel, M. Eyrich, S. Mueller-Weihrich, D. Niethammer, and R. Handgretinger Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases Bone Marrow Transplant. 33 2004 25 32
22. D.A. Lim, and A. Alvarez-Buylla Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis Proc. Natl. Acad. Sci. U. S. A. 96 1999 7526 7531
23. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the folin-phenol reagents J. Biol. Chem. 193 1951 265 275
24. E. Mezey, K.J. Chandross, G. Harta, R.A. Maki, and S.R. McKercher Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow Science 290 2000 1779 1782
25. E. Mezey, S. Key, G. Vogelsang, I. Szalayova, G.D. Lange, and B. Crain Transplanted bone marrow generates new neurons in human brains Proc. Natl. Acad. Sci. U. S. A. 100 2003 1364 1369
26. H. Muramatsu, P. Zou, H. Suzuki, Y. Oda, G.Y. Chen, N. Sakaguchi, S. Sakuma, N. Maeda, M. Noda, Y. Takada, and T. Muramatsu alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor J. Cell Sci. 117 2004 5405 5415
27. K. Nakano, M. Migita, H. Mochizuki, and T. Shimada Differentiation of transplanted bone marrow cells in the adult mouse brain Transplantation 71 2001 1735 1740
28. T. Nakayama, T. Momoki-Soga, and N. Inoue Astrocyte-derived factors instruct differentiation of embryonic stem cells into neurons Neurosci. Res. 46 2003 241 249
29. J.G. Nicholls, A.R. Martin, and B.G. Wallace From Neuron to Brain 3rd ed. 1992 Sinauer Sunderland, Massachusetts 149 152
30. D. Orlic, J. Kajstura, S. Chimenti, I. Jakoniuk, S.M. Anderson, B. Li, J. Pickel, R. McKay, B. Nadal-Ginard, D.M. Bodine, A. Leri, and P. Anversa Bone marrow cells regenerate infarcted myocardium Nature 410 2001 701 705
31. U. Paulus, P. Dreger, K. Viehmann, N. von Neuhoff, and N. Schmitz Purging peripheral blood progenitor cell grafts from lymphoma cells: quantitative comparison of immunomagnetic CD34+ selection systems Stem Cells 15 1997 297 304
32. B.E. Petersen, W.C. Bowen, K.D. Patrene, W.M. Mars, A.K. Sullivan, N. Murase, S.S. Boggs, J.S. Greenberger, and J.P. Goff Bone marrow as a potential source of hepatic oval cells Science 284 1999 1168 1170
33. C. Reali, M. Curto, V. Sogos, F. Scintu, S. Pauly, H. Schwarz, and F. Gremo Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: modulation by FGF-2 J. Neurosci. Res. 74 2003 67 73
34. C. Reali, F. Scintu, R. Pillai, R. Donato, F. Michetti, and V. Sogos S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microglia J. Neurosci. Res. 81 2005 677 686
35. J.L. Ridet, S.K. Malhotra, A. Privat, and F.H. Gage Reactive astrocytes: cellular and molecular cues to biological function Trends Neurosci. 20 1997 570 577
36. JR. Sanchez-Ramos Neural cells derived from adult bone marrow and umbilical cord blood J. Neurosci. Res. 69 2002 880 893
37. M. Sensenbrenner, K. Maderspach, L. Latzkovits, and G.G. Jaros Neuronal cells from chick embryo cerebral hemispheres cultivated on polylysine-coated surfaces Dev. Neurosci. 1 1978 90 101
38. O.E. Sigurjonsson, M.C. Perreault, T. Egeland, and J.C. Glover Adult human hematopoietic stem cells produce neurons efficiently in the regenerating chicken embryo spinal cord Proc. Natl. Acad. Sci. U. S. A. 102 2005 5227 5232
39. V. Sogos, F. Bussolino, E. Pilia, S. Torelli, and F. Gremo Acetylcholine-induced production of platelet-activating factor by human fetal brain cells in culture J. Neurosci. Res. 27 1990 706 711
40. H. Song, C.F. Stevens, and F.H. Gage Astroglia induces neurogenesis from adult neural stem cells Nature 417 2002 39 44
41. M.C. Tate, A.J. Garcia, B.G. Keselowsky, M.A. Schumm, D.R. Archer, and M.C. LaPlaca Specific beta1 integrins mediate adhesion, migration, and differentiation of neural progenitors derived from the embryonic striatum Mol. Cell. Neurosci. 27 2004 22 31
42. A.V. Terskikh, M.C. Easterday, L. Li, L. Hood, H. Kornblum, D.H. Geschwind, and L. Weissman From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs Proc. Natl. Acad. Sci. U. S. A. 98 2001 7934 7939
43. T. Tondreau, L. Lagneaux, M. Dejeneffe, M. Massy, C. Mortier, A. Delforge, and D. Bron Bone marrow-derived mesenchymal stem cells already express specific neural proteins before any differentiation Differentiation 72 2004 319 326
44. S. Torelli, V. Sogos, M.G. Ennas, C. Marcello, D. Cocchia, and F. Gremo Human fetal brain cultures: a model to study neural proliferation, differentiation and immunocompetence Adv. Exp. Med. Biol. 296 1991 121 134
45. E.M. Ullian, S.K. Sapperstein, K.S. Christopherson, and B.A. Barres Control of synapse number by glia Science 291 2001 657 661
46. J.C. van der Loo, X. Xiao, D. McMillin, K. Hashino, I. Kato, and D.A. Williams VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin J. Clin. Invest. 102 1998 1051 1061
47. D.A. Williams, M. Rios, C. Stephens, and V.P. Patel Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions Nature 352 1991 438 441
48. D. Woodbury, E.J. Schwarz, D.J. Prockop, and I.B. Black Adult rat and human bone marrow stromal stem cells differentiate into neurons J. Neurosci. Res. 61 2000 364 370