Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes

Journal of Ocular Pharmacology and Therapeutics

Volumn 20, Issue 3, 2004, Pages 189-200

  Park, Young Hyun ^a,b   Xu, Xin Rong ^a   Chiou, George C Y ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b Soonchunhyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLQUERCETIN; 7 HYDROXYFLAVONE; APIGENIN; CARBONYL DERIVATIVE; CATECHIN; CHRYSIN; FISETIN; FLAVANONE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL; FUSTIN; HYDROXYL GROUP; ISORHAMNETIN; KAEMPFEROL; LUTEOLIN; MICROSPHERE; MORIN; PENTAMETHYLQUERCETIN; RHAMNETIN; TAXIFOLIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL BOND; CILIARY BODY; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTRORETINOGRAPHY; EYE BLOOD FLOW; FEMALE; INTRAOCULAR HYPERTENSION; LIPOPHILICITY; MALE; METHYLATION; NONHUMAN; RABBIT; RAT; RETINA; RETINA ISCHEMIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE; FEMALE; FLAVONOIDS; INSTILLATION, DRUG; INTRAOCULAR PRESSURE; MALE; MICROSPHERES; OCULAR HYPERTENSION; RABBITS; RATS; RATS, LONG-EVANS; REGIONAL BLOOD FLOW; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 3042850912     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/1080768041223666     Document Type: Article

References (27)

1. Das, D.K. Naturally occurring flavonoids: Structure, chemistry, and high-performance liquid chromatography methods for separation and characterization. Methods Enzymol. 234:410-420, 1994.
2. Rice-Evans, C.A., and Packer, L. eds. Flavonoids in Health and Diseases. New York: Marcel Dekker; 1997.
3. Middleton J., E., Kandaswami, C., and Theoharides, T.C. The effect of plant flavonoids on mammalian cells: Implication for inflammation, heart disease, and cancer. Pharmacol. Rev. 52:673-751, 2000.
4. Heijnen, C.G.M., Haenen, G.R.M.M., van Acker, F.A.A., van der Vijgh, W.J.F., and Basr, A. Flavonoids as peroxynitrite scavengers: The role of the hydroxyl groups. Toxicol. In Vitro 15:3-6, 2001.
5. Matsuda, H., Morikawa, T., Toguchida, I., and Yoshikawa, M. Structural requirements of flavonoids and related compounds for aldolase reductase inhibitory activity. Chem. Pharm. Bull. 50:788-795, 2002.
6. Sadik, C.D., Sies, H., and Schewe, T. Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action. Biochem. Pharmacol. 65:773-781, 2003.
7. Vaya, J., Mahmood, S., Goldblum, A., Aviram, M., Volkova, N. Shaalan, A. Musa, R., and Tamir S. Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy. Phytochemistry 62:89-99, 2003.
8. Matsuda, H., Morikawa, T., Ando, S., Toguchida, I., and Yoshikawa, M. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Bioorganic Med. Chem. 11:1995-2000, 2003.
9. Chiou, G.C.Y., and Chen, Y.J. Effects of antiglaucoma drugs on ocular blood flow in ocular hypertensive rabbits. J. Ocular Pharmacol. Ther. 9:13-24, 1993.
10. Chiou, G.C.Y., and Chen, Y.J. Effects of D- and L-isomers of timolol on retinal and choroidal blood flow in ocular hypertensive rabbit eyes. J. Ocular Pharmacol. Ther. 8:183-190, 1992.
11. Chiou, G.C.Y. Review: Treatment of open-angle glaucoma and ischemic retinopathy with dopoamine antagonists. J. Ocular Pharmacol. Ther. 10:371-377, 1994.
12. O'Connor, P.R. Retinal Vascular Disease. New York: MEDCOM, Inc., 1974.
13. Lim, J.I. Age Related Macular Degeneration. New York: Marcel Dekker, 2002.
14. Quiroz-Mercado, H., Alfaro, D.V., Liggett, P.E., Tano, Y., and De Juan, E. Macular Surgery. New York: Lippincott Williams & Wilkins, 2000.
15. Piguest, B., Palmvang, I.B., Chisholm, I.H., Minassain, D., and Bird, A.C. Evolution of age-related macular degeneration with choroidal perfusion abnormality. Am. J. Ophthamol. 113:657-653, 1992.
16. Chiou, G.C.Y., and Chen, Y.J. Effects of dopamine agonist, bromocriptine, and some dopamine antagonists on ocular blood flow. J. Ocular Pharmacol. 8:285-294, 1992.
17. Chiou, G.C.Y., and Chen, Y.J. Improvement of ocular blood flow with dopamine antagonists on ocular hypertensive rabbit eyes. Acta Pharmacol. Sinica 13:481-484, 1992.
18. Chiou, G.C.Y., Liu, S.X.L., Li, B.H.P., Varma, R.S., and Chiang, C.H. Ocular hypotensive effects of arginine compounds and their actions on ocular blood flow. J. Ocular Pharmacol. Ther. 11:1-10, 1995.
19. Lin, S.X.L., Chiou, G.C.Y., and Varma, R.S. Improvement of retinal function after ischemia with L-arginine and its derivatives. J. Ocular Pharmacol. Ther. 11:261-265, 1995.
20. Wu, B.N., Hong, S.J., Shen, M.M., Chen, I.J., Liu, S.X.L., and Chiou, G.C.Y. Vaninolol: A novel compound for the treatment of glaucoma and ischemic retinopathy. J. Ocular Pharmacol. Ther. 11:215-222, 1995.
21. Xuan, B., Zhou, Y.H., Varma, R.S., and Chiou, G.C.Y. Effects of some N-nitropyrazole derivatives on ocular blood flow and retinal function recovery after ischemic insult. J. Ocular Pharmacol. Ther. 15:135-142, 1999.
22. Liu, S.X.L., Chiou, G.C.Y., Chiang, C.H., and Yao, Q.S. Increase of ocular blood flow by some phytogenic compounds. J. Ocular Pharmacol. Ther. 12:95-101, 1996.
23. Liu, S.X.L., Wang, M.S., Kapingu, M.C., and Chiou, G.C.Y. Facilitation of retinal function recovery by coumarin derivatives. J. Ocular Pharmacol. Ther. 13:69-79, 1997.
24. Xuan, B., Zhou, Y.H., Yang, R.L., Li, N., Min, Z.D., and Chiou, G.C.Y. Improvement of ocular blood flow and retinal functions with puerarin analogs. J. Ocular Pharmacol. Ther. 15:207-216, 1999.
25. Xuan, B., Zhou, Y.H., Li, N., Min, Z.D., and Chiou, G.C.Y. Effects of crocin analogs on ocular blood flow and retinal function. J. Ocular Pharmacol. Ther. 15:143-152, 1999.
26. Park, Y.H., and Chiou, G.C.Y. Structure-activity relationship between some natural flavonoids and ocular blood flow in the rabbit. J. Ocular Pharmacol. Ther. (in press).
27. Park, Y.H., Xu, X.R., and Chiou, G.C.Y. Role of hydroxy groups as natural flavones on ocular blood flow of rabbit and retinal function recovery after ischemic insult in rat eyes. J. Ocular Pharmacol. Ther. (in press).