Virus-induced neuronal apoptosis as pathological and protective responses of the host

Reviews in Medical Virology

Volumn 14, Issue 4, 2004, Pages 209-216

  Mori, Isamu ^a,b,c   Nishiyama, Yukihiro ^b   Yokochi, Takashi ^a   Kimura, Yoshinobu ^c  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c University of Fukui   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALPHA VIRUS; APOPTOSIS; BORNA DISEASE VIRUS; CENTRAL NERVOUS SYSTEM INFECTION; COXSACKIE VIRUS B3; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; DENGUE VIRUS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; IN VIVO STUDY; INFLUENZA VIRUS A; MUMPS VIRUS; NERVE CELL NECROSIS; NONHUMAN; OLFACTORY RECEPTOR; PARAINFLUENZA VIRUS 1; RABIES VIRUS; REOVIRUS; REVIEW; SINDBIS VIRUS; SUBACUTE SCLEROSING PANENCEPHALITIS; VIRUS ENCEPHALITIS; VIRUS INFECTION; WEST NILE FLAVIVIRUS;

APOPTOSIS; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; NEURONS; PERIPHERAL NERVOUS SYSTEM DISEASES; VIRUS DISEASES; VIRUSES;

EID: 3042835190     PISSN: 10529276     EISSN: None     Source Type: Journal    
DOI: 10.1002/rmv.426     Document Type: Review

References (56)

1. Fazakerley JK, Allsopp TE. Programmed cell death in virus infections of the nervous system. Curr Top Microbiol Immunol 2001; 253: 95-119.
2. Levine B. Apoptosis in viral infections of neurons: a protective or pathologic host response? Curr Top Microbiol Immunol 2002; 265: 95-118.
3. Anderson JR. The mechanisms of direct, virus-induced destruction of neurons. Curr Top Microbiol Immunol 2001; 253: 15-33.
4. Garden GA, Budd SL, Tsai E, et al. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci 2002; 22: 4015-4024.
5. Miura Y, Koyanagi Y, Mizusawa H. TNF-related apoptosis-inducing ligand (TRAIL) induces neuronal apoptosis in HIV-encephalopathy. J Med Dent Sci 2003; 50: 17-25.
6. DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis. J Infect Dis 2002; 186: 1547-1557.
7. Perkins D, Gyure KA, Pereira EFR, Aurelian L. Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase. J Neuro Virol 2003; 9: 101-111.
8. Hayashi M, Arai N, Satoh J, et al. Neurodegenerative mechanisms in subacute sclerosing panencephalitis. J Child Neurol 2002; 17: 725-730.
9. Yang J-S, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway. Emerg Infect Dis 2002; 8: 1379-1384.
10. Desprès P, Frenkiel M-P, Ceccaldi P-E, Dos Santos CD, Deubel V. Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent dengue viruses. J Virol 1998; 72: 823-829.
11. Takikita S, Takano T, Narita T, Takikita M, Ohno M, Shimada M. Neuronal apoptosis mediated by IL-1β expression in viral encephalitis caused by a neuroadapted strain of the mumps virus (Kilham strain) in hamsters. Exp Neurol 2001; 172: 47-59.
12. Kimura T, Griffin DE. Extensive immune-mediated hippocampal damage in mice surviving infection with neuroadapted Sindbis virus. Virology 2003; 311: 28-39.
13. Theerasurakarn S, Ubol S. Apoptosis induction in brain during the fixed strain of rabies virus infection correlates with onset and severity of illness. J Neuro-Virol 1998; 4: 407-414.
14. Galelli A, Baloul L, Lafon M. Abortive rabies virus central nervous infection is controlled by T lymphocyte local recruitment and induction of apoptosis. J Neuro Virol 2000; 6: 359-372.
15. Yan X, Prosniak M, Curtis MT, et al. Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice. J Neuro Virol 2001; 7: 518-527.
16. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol 1997; 71: 2100-2106.
17. Weissenböck H, Horning M, Hickey WF, Lipkin WI. Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats. Brain Pathol 2000; 10: 260-272.
18. Feuer R, Mena I, Pagarigan RR, Harkins S, Hassett DE, Whitton JL. Coxsackievirus B3 and the neonatal CNS. The roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease. Am J Pathol 2003; 163: 1379-1393.
19. Watanabe D, Honda T, Nishio K, Tomita Y, Sugiura Y, Nishiyama Y. Corneal infection of herpes simplex virus type 2-induced neuronal apoptosis in the brain stem of mice with expression of tumor suppressor gene (p53) and transcription factors. Acta Neuropathol 2000; 100: 647-653.
20. Mori I, Kimura Y. Apoptotic neurodegeneration induced by influenza A virus infection in the mouse brain. Microbes Infect 2000; 2: 1329-1334.
21. Mori I, Kimura Y. Neuropathogenesis of influenza virus infection in mice. Microbes Infect 2001; 3: 475-479.
22. Mori I, Liu B, Hossain MJ, et al. Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice. Virology 2002; 303: 287-296.
23. Mori I, Goshima F, Imai Y, et al. Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis. J Gen Virol 2002; 83: 2109-2116.
24. Mori I, Goshima F, Koshizuka T, et al. Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus. J Gen Virol 2003; 84: 2401-2408.
25. Neumann H, Medana IM, Bauer J, Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci 2002; 25: 313-319.
26. Mori I, Diehl AD, Chauhan A, Ljunggren H-G, Kristensson K. Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice. J Neuro Virol 1999; 5: 355-362.
27. Aronsson F, Karlsson H, Ljunggren H-G, Kristensson K. Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice. J Neuro Virol 2001; 7: 117-124.
28. Corasaniti MT, Rotiroti D, Nappi G, Bagetta G. Neurobiological mediators of neuronal apoptosis in experimental neuroAIDS. Toxicol Lett 2003; 139: 199-206.
29. Albright AV, Soldan SS, González-Scarano F. Pathogenesis of human immunodeficiency virus-induced neurological disease. J Neuro Virol 2003; 9: 222-227.
30. Jones M, Olafson K, Del Bigio MR, Peeling J, Nath A. Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) Tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. J Neuropathol Exp Neurol 1998; 57: 563-570.
31. Kim BO, Liu Y, Ruan Y, Xu ZC, Schantz L, He JJ. Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol 2003; 162: 1693-1707.
32. Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 2001; 29: 629-643.
33. Putcha GV, Moulder KL, Golden JP, et al. Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 2001; 29: 615-628.
34. Putcha GV, Le S, Frank S, et al. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 2003; 38: 899-914.
35. McLean TI, Bachenheimer SL. Activation of cJun N-terminal kinase by herpes simplex virus type 1 enhances viral replication. J Virol 1999; 73: 8415-8426.
36. Zachos G, Clements B, Conner J. Herpes simplex virus type 1 infection stimulates p38/c-Jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1. J Biol Chem 1999; 274: 5097-5103.
37. Ludwig S, Ehrhardt C, Neumeier ER, Kracht M, Rapp UR, Pleschka S. Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. J Biol Chem 2001; 276: 10990-10998.
38. Ludwig S, Planz O, Pleschka S, Wolff T. Influenza-virus-induced signaling cascades: targets for antiviral therapy? Trends Mol Med 2003; 9: 46-52.
39. Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun. J Virol 2001; 75: 11275-11283.
40. Murata T, Goshima F, Daikoku T, Takakuwa H, Nishiyama Y. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation. Genes Cells 2000; 5: 1017-1027.
41. Murata T, Goshima F, Yamauchi Y, Koshizuka T, Takakuwa H, Nishiyama Y. Herpes simplex virus type 2 US3 blocks apoptosis induced by sorbitol treatment. Microbes Infect 2002; 4: 707-712.
42. Nishiyama Y, Murata T. Anti-apoptotic protein kinase of herpes simplex virus. Trends Microbiol 2002; 10: 105-107.
43. Mori I, Goshima F, Koshizuka T, et al. The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice. Neurosci Lett 2003; 351: 201-205.
44. Fujimoto I, Takizawa T, Ohba Y, Nakanishi Y. Coexpression of Fas and Fas-ligand on the surface of influenza virus-infected cells. Cell Death Differ 1998; 5: 426-431.
45. Morishima Y, Gotoh Y, Zieg J, et al. β-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci 2001; 21: 7551-7560.
46. Nagai Y, Kato A. Accessory genes of the paramyxoviridae, a large family of nonsegmented negative-strand RNA viruses, as a focus of active investigation by reverse genetics. Curr Top Microbiol Immunol 2004; 283: 197-248.
47. Pyles RB. The association of herpes simplex virus and Alzheimer's disease: a potential synthesis of genetic and environmental factors. Herpes 2001; 8: 64-68.
48. Jackson AC, Park H. Apoptotic cell death in experimental rabies in suckling mice. Acta Neuropathol 1998; 95: 159-164.
49. Jackson AC. Rabies virus infection: an update. J Neuro Virol 2003; 9: 253-258.
50. Kristensson K. Sorting signals and targeting of infectious agents through axons: an annotation to the 100 years' birth of the name 'axon'. Brain Res Bull 1996; 41: 327-333.
51. Mori I, Komatsu T, Takeuchi K, Nakakuki K, Sudo M, Kimura Y. Parainfluenza virus type 1 infects olfactory neurons and establishes long-term persistence in the nerve tissue. J Gen Virol 1995; 76: 1251-1254.
52. Mori I, Nakakuki K, Kimura Y. Temperature-sensitive parainfluenza type 1 vaccine virus directly accesses the central nervous system by infecting olfactory neurons. J Gen Virol 1996; 77: 2121-2124.
53. Mori I, Yokochi T, Kimura Y. Role of influenza A virus hemagglutinin in neurovirulence for mammalians. Med Microbiol Immunol 2002; 191: 1-4.
54. Asano S, Honda T, Goshima F, Nishiyama Y, Sugiura Y. US3 protein kinase of herpes simplex virus protects primary afferent neurons from virus-induced apoptosis in ICR mice. Neurosci Lett 2000; 294: 105-108.
55. Mori I, Goshima F, Koshizuka T, et al. Iba1-expressing microglia respond to herpes simplex virus infection in the mouse trigeminal ganglion. Mol Brain Res 2003; 120: 52-56.
56. Ozaki N, Sugiura Y, Yamamoto M, Yokoya S, Wanaka A, Nishiyama Y. Apoptosis induced in the spinal cord and dorsal root ganglion by infection of herpes simplex virus type 2 in the mouse. Neurosci Lett 1997; 228: 99-102.