Protein C inhibitor as an anti-disseminated intravascular coagulation agent - Mechanism and modification

Current Medicinal Chemistry: Cardiovascular and Hematological Agents

Volumn 2, Issue 1, 2004, Pages 21-27

  Fujita, Mitsugu ^a   Izutani, W ^b   Takahashi, K ^b  

^a JCR Pharmaceuticals Co Ltd   (Japan)

^b NONE

Author keywords

Disseminated intravascular coagulation; N glycosylation site mutant; Protein C inhibitor; Sepsis

Indexed keywords

ACTIVATED PROTEIN C; ALANINE AMINOTRANSFERASE; ANTICOAGULANT AGENT; ASPARAGINE DERIVATIVE; ASPARTATE AMINOTRANSFERASE; BACTERIUM LIPOPOLYSACCHARIDE; BLOOD CLOTTING FACTOR; CHEMOTACTIC FACTOR; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN DEGRADATION PRODUCT; GLYCAN DERIVATIVE; GLYCOPROTEIN; HEPARIN; PKSI 527; PLASMA KALLIKREIN; PLASMINOGEN ACTIVATOR INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 3; PROCOAGULANT; PROTEIN C; PROTEINASE; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

BLEEDING DISORDER; BLOOD VESSEL INJURY; CHEMICAL MODIFICATION; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG BINDING SITE; DRUG MECHANISM; DRUG PURIFICATION; ENDOTHELIUM CELL; FIBRINOLYSIS; GLYCOSYLATION; GRAM NEGATIVE SEPSIS; HUMAN; IC 50; INFLAMMATION; MEDIATOR RELEASE; MICROVASCULATURE; MULTIPLE ORGAN FAILURE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PATHOPHYSIOLOGY; PHAGOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTHROMBIN TIME; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION; THROMBOGENESIS; URINE LEVEL; VASCULAR ENDOTHELIUM;

ANIMALS; CLINICAL TRIALS; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOTHELIUM, VASCULAR; GLYCOSYLATION; HUMANS; KALLIKREINS; POLYSACCHARIDES; PROTEIN C INHIBITOR; THROMBIN; THROMBOMODULIN;

EID: 3042820886     PISSN: 15680169     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568016043477404     Document Type: Review

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