The trimannosyl cores of N-glycans are important for the procoagulant protease-inhibitory activity of urinary protein C inhibitor

Thrombosis Research

Volumn 104, Issue 1, 2001, Pages 65-74

  Izutani, Wakako ^a   Fujita, Mitsugu ^a   Nishizawa, Koji ^a   Koga, Junichi ^a  

^a JCR Pharmaceuticals Co Ltd   (Japan)

Author keywords

N glycan structure; Protease inhibitory activity; Urinary protein C inhibitor

Indexed keywords

ASPARAGINE; DEXTRO PHENYLALANYLPIPECOLYLARGININE 4 NITROANILIDE; GALACTOSE; MANNOSE; N ACETYLNEURAMINIC ACID; PLASMA KALLIKREIN; PLASMINOGEN ACTIVATOR INHIBITOR; PROCOAGULANT; PROTEINASE INHIBITOR; S 2303; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN; MOLECULE; PRIORITY JOURNAL; PROTEIN URINE LEVEL;

AMINO ACID SEQUENCE; BINDING SITES; CARBOHYDRATE SEQUENCE; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; KALLIKREINS; MANNOSE; MOLECULAR SEQUENCE DATA; PROTEIN C INHIBITOR; SERINE PROTEINASE INHIBITORS; THROMBIN; TRISACCHARIDES;

EID: 0035479233     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(01)00342-5     Document Type: Article

References (32)

1. Mechanism of inhibition of activated protein C by protein C inhibitor
2. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
3. Protein C inhibitor. Purification from human plasma and characterization
4. Identification of monoclonal antibodies that inhibit the function of protein C inhibitor. Evidence for heparin-independent inhibition of activated protein C in plasma
5. Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor
6. Protein C inhibitor: Purification and proteinase reactivity
7. Purification and characterization of plasma protein C inhibitor
8. Intermolecular interactions between protein C inhibitor and coagulation proteases
9. 1-antitrypsin for structure and function of serpins
10. Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily
11. Effect of urinary protein C inhibitor on lipopolysaccharide-induced disseminated intravascular coagulation in rats
12. Urinary protein C inhibitor as a therapeutic agent to disseminated intravascular coagulation (DIC): A comparison with low molecular weight heparin in rats with lipopolysaccharide-induced DIC
13. Protein C inhibitor: Structure and function
14. Purification and characterization of a novel inhibitor of urokinase from human urine. Quantitation and preliminary characterization in plasma
15. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3
16. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen
17. Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system
18. Heparin binding to protein C inhibitor
19. A comparison of three heparin binding serine protease inhibitors
20. + helix in heparin binding to protein C inhibitor
21. Protein C inhibitor
22. Release of O-linked sugar chains from glycoproteins with anhydrous hydrazine and pyridylamination of the sugar chains with improved reaction conditions
23. Structure of a sugar chain of a protease inhibitor isolated from barbados pride (Caesalpinia pulcherrima Sw.) seeds
24. Analyses of N-linked oligosaccharides using a two-dimensional mapping technique
25. Classification of sugar chains of glycoproteins by analyzing reducing end oligosaccharides obtained by partial acid hydrolysis
26. 4-3GlcAβ1-3Galβ1-3(±Siaα2-6)Galβ1- 4Xyl
27. Structural elucidation of a variety of GalNAc-containing N-linked oligosaccharides from human urinary kallidinogenase
28. Cloning and high-level expression of chitinase-encoding gene of Streptomyces plicatus
29. Analysis of glycoprotein-associated oligosaccharides
30. Immunochemical studies on the combining site of the D-galactose/N-acetyl-D-galactosamine specific lectin from Erythrina cristagalli seeds
31. Some properties of purified phytohemagglutinin from Lens culinaris seeds
32. Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding