T cell activation: In vivo veritas

Immunology and Cell Biology

Volumn 82, Issue 3, 2004, Pages 260-268

  Fazekas De St Groth, Barbara ^a,b   Smith, Adrian L ^a   Higgins, Caroline A ^a  

^a CENTENARY INSTITUTE   (Australia)

^b NONE   (Australia)

Author keywords

Activation; T cells; Thymus

Indexed keywords

CD38 ANTIGEN; CD4 ANTIGEN; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ANTIGEN EXPRESSION; AUTOCRINE EFFECT; CELL ACTIVATION; CELL DIVISION; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHENOTYPIC VARIATION; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; REVIEW; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2;

EID: 3042806971     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0818-9641.2004.01243.x     Document Type: Review

References (22)

1. Kaech SM, Hemby S, Kersh E, Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002; 111: 837-51.
2. Zuniga-Pflucker J, Schwartz H, Lenardo M. Gene transcription in differentiating immature T cell receptorneg thymocytes resembles antigen-activated mature T cells. J. Exp. Med. 1993; 178: 1139-3349.
3. Yamashita I, Nagata T, Tada T, Nakayama T. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 1993; 5: 1139-50.
4. Ashton-Rickardt PG, Bandeira A, Delaney JR et al. Evidence for a differential avidity model of T cell selection in the thymus. Cell 1994; 76: 651-63.
5. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 1994; 76: 17-27.
6. Itoh M, Takahashi T, Sakaguchi N et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999; 162: 5317-26.
7. Jordan MS, Boesteanu A, Reed AJ et al. Thymic selection of CD4(+)CD25(+) regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001; 2: 301-6.
8. Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origins of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002; 3: 756-63.
9. Suto A, Nakajima H, Ikeda K et al. CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms. Blood 2002; 99: 555-60.
10. Fazekas de St. Groth B, Patten PA, Ho WY, Rock EP. An analysis of T cell receptor-ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis. In: Alt FW, Vogel HJ (eds). Molecular Mechanisms of Immunological Self-Recognition. San Diego: Academic Press, 1992; 123-7.
11. Smith AL, Wikstrom ME, Fazekas de St. Groth B. Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity 2000; 13: 783-94.
12. Fazekas de St. Groth B. The evolution of self tolerance: a new cell is required to meet the challenge of self-reactivity. Immunol. Today 1998; 19: 448-54.
13. Fazekas de St. Groth B. DCs and peripheral T cell tolerance. Semin. Immunol. 2001; 13: 311-21.
14. Fazekas de St. Groth B, Smith AL, Bosco J, Sze DM-Y, Power CA, Austen FI. Experimental models linking dendritic cell lineage, phenotype and function. Immunol. Cell Biol. 2002; 80: 469-76.
15. Fazekas de St. Groth B, Smith AL, Koh W-P, Girgis L, Cook MC, Bertolino P. CFSE and the virgin lymphocyte: a marriage made in heaven. Immunol. Cell Biol. 1999; 77: 530-8.
16. high expression as a marker. J. Immunol. 1999; 163: 5708-14.
17. Budd RC, Cerottini J-C, Horvath C, Bron C, Pedrazzini T, Howe RC, MacDonald HR. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomittant with antigenic stimulation. J. Immunol. 1987; 138: 3120-9.
18. Lambrecht BN, Pauwels RA, Fazekas de St. Groth B. Induction of rapid T cell activation, division and recirculation by intratracheal injection of dendritic cells in a TCR-transgenic model. J. Immunol. 2000; 164: 2937-46.
19. Smith KA. Interleukin-2. Curr. Opin. Immunol. 1992; 4: 271-6.
20. Nakajima H, Liu XW, Wynshaw-Boris A et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity 1997; 7: 691-701.
21. Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002; 16: 23-35.
22. Deenick EK, Gett AV, Hodgkin PD. Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J. Immunol. 2003; 16: 4963-72.